Protein detail
ASIC1
Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2)
Protein symbol ASIC1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 2 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2)
Transmembrane
50..66; Helical; 428..458; Discontinuously helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificAstrocytesSingle-Nuclei Brain SpecificBergmann gliaBlood Cell SpecificgdT-cell
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ASIC1 | PRKACA | P17612 | S | 525 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAPhosphoSite | KEA:12578970 |
| ASIC1 | PRKX | P51817 | S | 525 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ASIC1 | PRKY | O43930 | S | 525 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PICK1 | Q9NRD5 | ASIC1 | P78348 | Yes | Yes | No | SIGNORHPRDHINTBioGRIDIntActSPIKE_LCLit-BM-17 | HINT:11802773IntAct:11802773Lit-BM-17:11802773SIGNOR:11802773SPIKE_LC:11802773BioGRID:12578970HINT:11739374HPRD:11739374Lit-BM-17:12578970SPIKE_LC:16713569HINT:12578970HPRD:11802773HPRD:12578970HINT:33961781 |
| KAPCA | P17612 | ASIC1 | P78348 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite | SIGNOR:12578970KEA:12578970PhosphoSite:12578970ProtMapper:12578970HPRD:12578970 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ASF1BASIC1H3C11H4C4HAT1IPO4PRKACARBBP4RBBP7STMN1 | O14929P16949P17612P62805P68431P78348Q09028Q16576Q8TEX9Q9NVP2 | 1:1:1:2:4:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC3787 | ||
| ASF1AASH1LASIC1CHAF1ADNAJB5H3-3AH3-4H4C4PBRM1SMARCA4SMARCA5SUMO1TBPL2 | O60264O75953P51532P62805P63165P78348P84243Q13111Q16695Q6SJ96Q86U86Q9NR48Q9Y294 | 1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4490 | ||
| ASIC1 | P78348 | 3 | PDB | PDB:6l6iPDB:7cfsPDB:6l6n |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting|Mass spectrometry|FACS | 1 | 39136554 |
Sequence, Structure & Domains
Sequences
Length
528
Mass
59,909
Sequence
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Asic1a; Synonyms=hvariant 2; IsoId=P78348-2; Sequence=Displayed; Name=1; Synonyms=hvariant 1; IsoId=P78348-1; Sequence=VSP_015596; Name=Asic1b; Synonyms=hvariant 3; IsoId=P78348-3; Sequence=VSP_045298
Alternative Sequence
1..185; MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFK -> MPIQIFCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEAFSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFS (in isoform Asic1b); 433; G -> GELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLG (in isoform 1)
3D Structural Models
Turn
46..50; 112..116; 285..287
Helix
25..34; 38..40; 51..61; 63..70; 100..102; 105..111; 132..141; 154..161; 165..168; 181..183; 214..216; 226..228; 258..261; 307..323; 339..344; 346..355; 358..360; 384..393; 398..404; 429..448
Beta Strand
73..81; 89..95; 169..174; 184..189; 192..197; 208..211; 217..223; 243..250; 252..254; 263..265; 269..281; 302..304; 332..334; 366..382; 405..426
3D Structure
Electron microscopy (3); X-ray crystallography (2)
Domain & Motif Annotations
Motif
444..446; GAS motif; ion selectivity filter
Domain (CC)
The second transmembrane domain (TM2) is a discontinuous alpha-helix disrupted by the GAS motif, which forms the selectivity filter by adopting an extended, belt-like conformation aligned approximately parallel to the membrane plane. This peptide belt encircles the waist of the channel and divides TM2 into two discontinuous helical segments. The distal helical segment of TM2 interacts with the cytoplasmic portion of the first transmembrane domain (TM1) from a neighboring subunit, contributing to the structural and functional integrity of the channel.
Protein Families
- Amiloride-sensitive sodium channel (TC 1.A.6) family
- ASIC1 subfamily
Sequence Similarities
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
Clinical Relevance
Related Diseases
Biomarker
Approved; Phase 1
Drugs
[DES-ARG10]KALLIDINCHROMAN 28NPC 18565PS020990COMPOUND 11 [PMID: 12812482][DES-ARG9]BRADYKININ[SAR,D-PHE8,DES-ARG9]BRADYKININICATIBANTD-LYS0-[DES-ARG10]KALLIDIN[125I]HPP-DESARG10HOE140LYS-KALLIDINB-9958MET-LYS-BRADYKININB-10356SSR240612NPC 17731[LEU9,DES-ARG10]KALLIDINCOMPOUND 12 [PMID: 12723943]T-KININB-9858AMILORIDE[DES-PHE9,DES-ARG10]KALLIDINJMV1431NVP-SAA164[D-LYS1,DES-ARG10]KALLIDIN[DES-ARG10]ICATIBANTNULLR-954NG29B-9430[3H]LYS-[DES-ARG9]BKBRADYKININAC-LYS-[MEALA6,LEU8,DES-ARG9]BRADYKININ[3H]LYS-[LEU8][DES-ARG9]BKKALLIDINR-715[DES-ARG11]T-KININ[DES-PRO8,DES-PHE9,DES-ARG10]KALLIDIN[LEU8,DES-ARG9]BRADYKININ
Interaction Protein
ENSG00000100151
Interaction Count
1
Interaction Dataset
intact_biogrid