Protein detail

OLR1

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]

Entry name OLR1	UniProt ID P78380	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Transmembrane

37..57; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000173391

Entrez Gene Symbol

OLR1

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M17 Pid notch pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	LRdb	No	Yes	Yes	Yes	No
receptor	receptor	Baccin2019	No	Yes	Yes	Yes	No
scavenger	receptor	Almen2009	No	Yes	Yes	Yes	No
class_e	receptor	Surfaceome	No	Yes	Yes	Yes	No
scar	receptor	Surfaceome	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

54 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HMGCS1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2L POLR3D POLR3G POLR3H RRN3 UBC	O15160 O15318 O95602 P05423 P0CG48 P0DPB5 P19388 P52434 P61218 P62875 Q01581 Q9GZS1 Q9H9Y6 Q9NYV6 Q9Y535	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7095
POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2F RRN3	O15160 O15446 O95602 P0DPB5 P61218 Q3B726 Q9GZS1 Q9H9Y6 Q9NYV6 Q9P1U0	0:0:0:0:0:0:0:0:0:0	hu.MAP2
GPN3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2F POLR3K RRN3	O15160 O15446 O95602 P0DPB5 P61218 Q3B726 Q9GZS1 Q9H9Y6 Q9NYV6 Q9P1U0 Q9UHW5 Q9Y2Y1	0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR3K	O15160 O15446 O95602 P0DPB5 Q3B726 Q9GZS1 Q9H9Y6 Q9Y2Y1	0:0:0:0:0:0:0:0	hu.MAP2
POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RRN3	O15160 O15446 O95602 P0DPB6 P19388 P52434 P53803 P61218 P62875 Q3B726 Q9GZS1 Q9H9Y6 Q9NYV6 Q9P1U0	1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:7oba
POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L	O15160 O15446 O95602 P0DPB6 P19388 P52434 P53803 P61218 P62875 Q9GZS1 Q9H9Y6 Q9P1U0	1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8a43
POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2F RRN3	O15160 O15446 O95602 P0DPB6 P61218 Q3B726 Q9GZS1 Q9H9Y6 Q9NYV6 Q9P1U0	0:0:0:0:0:0:0:0:0:0	hu.MAP2
GPN3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2F POLR3K RRN3	O15160 O15446 O95602 P0DPB6 P61218 Q3B726 Q9GZS1 Q9H9Y6 Q9NYV6 Q9P1U0 Q9UHW5 Q9Y2Y1	0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR3K	O15160 O15446 O95602 P0DPB6 Q3B726 Q9GZS1 Q9H9Y6 Q9Y2Y1	0:0:0:0:0:0:0:0	hu.MAP2
POLR1A POLR1C POLR1E POLR1G	O15160 O15446 O95602 Q9GZS1	1:1:1:1	CompleatCFinder	Compleat:HC6694

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	28369848

Sequence, Structure & Domains

Sequences

Length

273

Mass

30,959

Sequence

MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P78380-1; Sequence=Displayed; Name=2; IsoId=P78380-2; Sequence=VSP_042555; Name=3; IsoId=P78380-3; Sequence=VSP_045277

Alternative Sequence

142..273; APCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ -> GLHPASNFLFQFSILDGAVSEEPQLPMALGGRFSFDAPLI (in isoform 2); 189..273; DFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ -> I (in isoform 3)

3D Structural Models

Turn

195..197

Helix

165..174; 185..194

Beta Strand

148..151; 154..158; 202..210; 225..227; 230..233; 242..247; 250..255; 260..267

3D Structure

X-ray crystallography (13)

Domain & Motif Annotations

Coiled Coil

64..123

Domain (CC)

The cytoplasmic region is required for subcellular sorting on the cell surface.; DOMAIN: The C-type lectin domain mediates the recognition and binding of oxLDL.

Domain (FT)

151..265; C-type lectin

Region

1..22; Disordered; 58..150; Neck

Clinical Relevance

Related Diseases

Arterial occlusive disease Cardiovascular disease Coronary atherosclerosis

Biomarker

Discontinued in Phase 1; Phase 2

Drugs

ORTICUMAB