Protein detail

OLR1

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]

Entry name OLR1	UniProt ID P78380	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Transmembrane

37..57; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000173391

Entrez Gene Symbol

OLR1

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M17 Pid notch pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	LOCATE	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

54 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
DNA-directed RNA polymerase I complex	POLR1A POLR1B POLR1C POLR1D POLR1G	O15160 O15446 O95602 P0DPB5 Q9H9Y6	1:1:1:1:1	Compleat	Compleat:HC1148	9540830
DNA-directed RNA polymerase I complex	POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L	O15160 O15446 O95602 P0DPB6 P19388 P52434 P53803 P61218 P62875 Q3B726 Q9GZS1 Q9H9Y6 Q9P1U0	1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortalPDB	PDB:7OBBPDB:7obbPDB:7ob9PDB:7OB9PDB:7vbcPDB:7vbbPDB:7vbaintact:EBI-9014213	23150253 14755292 34887565
DNA-directed RNA polymerase I complex	POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L TCOF1	O15160 O95602 P0DPB5 P19388 P52434 P53803 P61218 P62875 Q13428 Q3B726 Q9GZS1 Q9H9Y6 Q9P1U0	1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC3176	8334985
HT_DM_Cluster265	POLR1C POLR3B POLR3H	O15160 Q9NW08 Q9Y535	1:1:1	Compleat	Compleat:HC121	22036573
NMI-POLR1B-RRN3 complex	NMI POLR1B RRN3	Q13287 Q9H9Y6 Q9NYV6	1:1:1	CompleatCORUM	CORUM:1557Compleat:HC3398	15558034
POLR1B-RRN3 complex	POLR1B RRN3	Q9H9Y6 Q9NYV6	1:1	CompleatCORUM	CORUM:1558Compleat:HC2043	15558034
RNA Polymerase I	POLR1A POLR1B POLR1C POLR1D POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L	O15160 O15446 O95602 P0DPB5 P0DPB6 P19388 P52434 P53803 P61218 P62875 Q3B726 Q9GZS1 Q9H9Y6 Q9P1U0	0:0:0:0:0:0:0:0:0:0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C390
	BATF2 POLR1C POLR1D POLR2E POLR2F POLR2H POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G SUMO2 TBP	O14802 O15160 O15318 P05423 P0DPB5 P19388 P20226 P52434 P61218 P61956 Q8N1L9 Q9BUI4 Q9H1D9 Q9NVU0 Q9NW08	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7119
	POLR1C POLR1D POLR3A POLR3B POLR3E POLR3H RAE1	O14802 O15160 P0DPB5 P78406 Q9NVU0 Q9NW08 Q9Y535	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9764
	CUX1 ELAC2 HSPA8 POLR1D POLR2E POLR2F POLR2H POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G	O14802 O15318 P05423 P0DPB5 P11142 P19388 P39880 P52434 P61218 P62875 Q9BQ52 Q9BUI4 Q9H1D9 Q9NVU0 Q9NW08	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6342

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	28369848

Sequence, Structure & Domains

Sequences

Length

273

Mass

30,959

Sequence

MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P78380-1; Sequence=Displayed; Name=2; IsoId=P78380-2; Sequence=VSP_042555; Name=3; IsoId=P78380-3; Sequence=VSP_045277

Alternative Sequence

142..273; APCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ -> GLHPASNFLFQFSILDGAVSEEPQLPMALGGRFSFDAPLI (in isoform 2); 189..273; DFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ -> I (in isoform 3)

3D Structural Models

Turn

195..197

Helix

165..174; 185..194

Beta Strand

148..151; 154..158; 202..210; 225..227; 230..233; 242..247; 250..255; 260..267

3D Structure

X-ray crystallography (13)

Domain & Motif Annotations

Coiled Coil

64..123

Domain (CC)

The cytoplasmic region is required for subcellular sorting on the cell surface.; DOMAIN: The C-type lectin domain mediates the recognition and binding of oxLDL.

Domain (FT)

151..265; C-type lectin

Region

1..22; Disordered; 58..150; Neck

Clinical Relevance

Related Diseases

Arterial occlusive disease Cardiovascular disease Coronary atherosclerosis

Biomarker

Discontinued in Phase 1; Phase 2

Drugs

ORTICUMAB