Protein detail
PRAME
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)
Protein symbol PRAME | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CT130MAPE
Gene Description
PRAME nuclear receptor transcriptional regulator
Chromosome
22
Position
22547701-22559361
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PRAME complex | CUL2ELOBELOCLAGE3OSGEPPRAMERBX1 | P62877P78395Q13617Q14657Q15369Q15370Q9NPF4 | 0:0:0:0:0:0:0 | CORUM | CORUM:7556 | 22912744 |
| PRAME-Cullin2 ubiquitin ligase complex | CUL2PRAME | P78395Q13617 | 0:0 | CORUM | CORUM:6736 | 21822215 |
| PRAME-Elongin C-Elongin B E3 ubiquitin ligase complex | CUL2ELOBELOCPRAMERBX1 | P62877P78395Q13617Q15369Q15370 | 1:1:1:1:1 | ComplexPortal | intact:EBI-9010045 | 2722266021822215226497762346092314755292 |
| PRAME-ElonginBC ubiquitin ligase | ELOBELOCPRAME | P78395Q15369Q15370 | 0:0:0 | CORUM | CORUM:6738 | 21822215 |
| PRAMEF10PRAMEF17 | O60809Q5VTA0 | 0:0 | hu.MAP2 | |||
| PRAMEF15PRAMEF4PRAMEF5 | O60810P0DUQ1Q5TYX0 | 0:0:0 | hu.MAPhu.MAP2 | |||
| PRAMEF4PRAMEF5PRAMEF9 | O60810P0DUQ2Q5TYX0 | 0:0:0 | hu.MAP2 | |||
| PRAMEF15PRAMEF5 | P0DUQ1Q5TYX0 | 0:0 | hu.MAP2 | |||
| PRAMEF5PRAMEF9 | P0DUQ2Q5TYX0 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36550367 |
Sequence, Structure & Domains
Sequences
Length
509
Mass
57,890
Sequence
MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVLYPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEPILCPCFMPN
3D Structural Models
Domain & Motif Annotations
Repeat
116..145; LRR 1; degenerate; 207..231; LRR 2; degenerate; 232..258; LRR 3; degenerate; 259..294; LRR 4; degenerate; 295..320; LRR 5; 321..352; LRR 6; 353..371; LRR 7; 377..404; LRR 8; 405..429; LRR 9
Region
416..509; Mediates interaction with RARA
Protein Families
PRAME family
Sequence Similarities
Belongs to the PRAME family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1; Phase 1/2
Interaction Protein
ENSG00000092094ENSG00000154582ENSG00000196976
Interaction Count
3
Interaction Dataset
biogrid_bioplexintact_biogrid