Protein detail
X3CL1
Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
Protein symbol X3CL1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
Protein Class
Plasma proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Transmembrane
342..362; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ABCD-3C3XkineCXC3CXC3CNTNSCYD1
Gene Description
C-X3-C motif chemokine ligand 1
Chromosome
16
Position
57372477-57385044
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificliverCell SpecificHepatocytesSecretome LocationSecreted to bloodSecretome FunctionTransport
Function & Pathway
Protein Function
Predicted secreted proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
59 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| chemokine | ligand | HGNC | Yes | No | Yes | Yes | No |
| ligand | ligand | HGNC | Yes | No | Yes | Yes | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| ligand | ligand | GO_Intercell | Yes | No | Yes | Yes | No |
| ligand | ligand | ICELLNET | Yes | No | Yes | Yes | No |
| ligand | ligand | CellChatDB | Yes | No | Yes | Yes | No |
| ligand | ligand | CellTalkDB | Yes | No | Yes | Yes | No |
| ligand | ligand | Ramilowski2015 | Yes | No | Yes | Yes | No |
| ligand | ligand | Kirouac2010 | Yes | No | Yes | Yes | No |
| ligand | ligand | Guide2Pharma | Yes | No | Yes | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| X3CL1 | P78423 | CX3C1 | P49238 | Yes | Yes | No | iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb | Cellinker:11432858Cellinker:9390561LRdb:10699158SPIKE_LC:16189514connectomeDB2020:9931005scConnect:14607932connectomeDB2020:9390561SIGNOR:11432858HINT:9931005Cellinker:14607932HPRD:9390561HPRD:9931005HPMR:11432858InnateDB:9931005HINT:23125415Guide2Pharma:14607932connectomeDB2020:11432858ICELLNET:22633458Cellinker:9931005InnateDB:9390561Lit-BM-17:10488147DIP:10488147Lit-BM-17:9931005connectomeDB2020:14607932Cellinker:28389721 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
397
Mass
42,203
Sequence
MAPISLSWLLRLATFCHLTVLLAGQHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNGGTFEKQIGEVKPRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQSPRPENSLEREEMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDAQAATRRQAVGLLAFLGLLFCLGVAMFTYQSLQGCPRKMAGEMAEGLRYIPRSCGSNSYVLVPV
3D Structural Models
Turn
68..70
Helix
27..29; 45..47; 56..58; 80..90; 93..96
Beta Strand
34..36; 48..53; 59..61; 63..67; 72..75
3D Structure
Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
133..147; Polar residues; 193..202; Polar residues; 219..243; Low complexity
Region
25..100; Chemokine and involved in interaction with ITGAV:ITGB3 and ITGA4:ITGB1; 101..341; Mucin-like stalk; 128..265; Disordered; 289..309; Disordered
Protein Families
Intercrine delta family
Sequence Similarities
Belongs to the intercrine delta family.