Protein detail
JAG1
Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Protein symbol JAG1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Protein Class
CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Disease related genes
Transmembrane
1068..1093; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
AGSAHDAWSCD339HJ1JAGL1
Gene Description
Jagged canonical Notch ligand 1
Chromosome
20
Position
10637684-10673999
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificpancreasCell SpecificAlveolar cells type 1
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa01522 Endocrine resistance
- KEGG:hsa04330 Notch signaling pathway
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05207 Chemical carcinogenesis - receptor activation
- KEGG:hsa05224 Breast cancer
Reactome
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9830369 kidney development
- R-hsa-9831926 nephron development
- R-hsa-2979096 notch2 activation and transmission of signal to the nucleus
- R-hsa-9013507 notch3 activation and transmission of signal to the nucleus
- R-hsa-9013700 notch4 activation and transmission of signal to the nucleus
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8941856 runx3 regulates notch signaling
- R-hsa-157118 signaling by notch
- R-hsa-1980143 signaling by notch1
- R-hsa-2691230 signaling by notch1 hd domain mutants in cancer
- R-hsa-2644602 signaling by notch1 pest domain mutants in cancer
- R-hsa-2660825 signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant
- R-hsa-1980145 signaling by notch2
- R-hsa-9012852 signaling by notch3
- R-hsa-9013694 signaling by notch4
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-8878159 transcriptional regulation by runx3
Canonical Pathways
- M88 Pid cd8 tcr pathway
- M54 Pid il12 2pathway
- M272 Pid cd8 tcr downstream pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | No | Yes | No |
| ecm | ecm | OmniPath | Yes | No | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
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Regulatory Interaction Network
9 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 30915084 |
Sequence, Structure & Domains
Sequences
Length
1,218
Mass
133,799
Sequence
MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78504-1; Sequence=Displayed; Name=2; IsoId=P78504-2; Sequence=VSP_056532
Alternative Sequence
1..159; Missing (in isoform 2)
3D Structural Models
Turn
61..63; 193..196; 226..229; 240..242; 268..270; 290..293
Helix
299..303
Beta Strand
33..43; 52..57; 73..81; 88..90; 95..98; 103..105; 118..124; 130..140; 143..147; 150..160; 163..172; 174..187; 203..205; 208..212; 218..220; 257..259; 273..275; 277..280; 286..289; 295..297; 311..316; 319..323; 328..330
3D Structure
NMR spectroscopy (1); X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
1189..1199; Polar residues
Domain (CC)
The second EGF-like domain is atypical.
Domain (FT)
185..229; DSL; 230..263; EGF-like 1; 264..294; EGF-like 2; atypical; 296..334; EGF-like 3; 336..372; EGF-like 4; 374..410; EGF-like 5; calcium-binding; 412..448; EGF-like 6; calcium-binding; 450..485; EGF-like 7; calcium-binding; 487..523; EGF-like 8; calcium-binding; 525..561; EGF-like 9; 586..627; EGF-like 10; 629..665; EGF-like 11; calcium-binding; 667..703; EGF-like 12; calcium-binding; 705..741; EGF-like 13; 744..780; EGF-like 14; 782..818; EGF-like 15; calcium-binding; 820..856; EGF-like 16; calcium-binding
Region
199..207; Important for interaction with NOTCH1; 1152..1218; Disordered
Clinical Relevance
Disease Involvement
Charcot-Marie-Tooth diseaseDeafnessDisease variantNeurodegenerationNeuropathy
Interaction Protein
ENSG00000148400
Interaction Count
1
Interaction Dataset
intact_biogrid