Protein detail

ENTK

Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]

Entry name
ENTK
UniProt ID
P98073
EVMP confidence score
0.28
Supporting publications (n)
1
Transmembrane count
1
Protein classification
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Basic Information
Protein Names
Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]
Protein Class (5)
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function (7)
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
  • Potential drug targets
  • Peptidases:Serine-type peptidases
  • Enzymes
  • ENZYME proteins:Hydrolases
  • Disease related genes
Transmembrane
19..47; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
ENSG00000154646
Entrez Gene Symbol
TMPRSS15
Gene Synonym (3)
ENTKMGC133046PRSS7
Gene Description
Transmembrane serine protease 15
Chromosome
21
Position
18269116-18485879
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (7)
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
  • Potential drug targets
  • Peptidases:Serine-type peptidases
  • Enzymes
  • ENZYME proteins:Hydrolases
  • Disease related genes
Cellular Component (2)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Clinical-translation mediation
Relations & Evidence23

Ligand-Receptor Signaling (20)

20 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
extracellularextracellularOmniPath
ecm_regulatorecm_regulatorMatrisomeYes
ecm_regulatorecm_regulatorOmniPathYes
cell_surface_enzymecell_surface_enzymeSurfaceomeYes
scavenger_receptor_cysteine_richcell_surface_enzymeOmniPathYes
cell_surface_enzymecell_surface_enzymeOmniPathYes
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PRSS1TMPRSS15P07477P980731:2PDBPDB:8ziyPDB:8h3sPDB:8zj4PDB:8zivPDB:8zi4
TMPRSS15P980734PDBPDB:8ziwPDB:8zizPDB:7wr7PDB:4dgjPDB:7wqzPDB:6zovPDB:7wqwPDB:8h3u

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry139195200
Sequence, Structure & Domains

Sequences

Length
1,019
Mass
112,935
Sequence
MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH

3D Structural Models

Turn
540..543; 672..674; 870..873
Helix
658..660; 712..718; 824..827; 834..836; 938..944; 1007..1009; 1011..1015
Beta Strand
536..539; 551..553; 555..557; 563..572; 578..583; 586..589; 594..596; 598..600; 608..617; 626..636; 647..649; 655..657; 661..665; 668..670; 693..695; 698..700; 724..727; 739..742; 750..752; 765..767; 785..787; 799..804; 807..814; 816..822; 837..842; 855..864; 878..884; 909..919; 929..936; 946..948; 954..957; 962..964; 974..979; 982..991; 993..996; 1002..1006
3D Structure
Electron microscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)
54..169; SEA; 182..223; LDL-receptor class A 1; 225..334; CUB 1; 342..504; MAM; 524..634; CUB 2; 641..679; LDL-receptor class A 2; 678..771; SRCR; 785..1019; Peptidase S1
Protein Families
Peptidase S1 family
Sequence Similarities
Belongs to the peptidase S1 family.
Clinical Relevance
Drug Targets
Patented-recorded target
Drugs (5)
ALEXIDINE HYDROCHLORIDECHEMBL:CHEMBL1534034CALMIDAZOLIUM CHLORIDETHONZONIUM BROMIDEAKT INHIBITOR IV
Antibody (3)
HPA015611HPA034857HPA072934
Supporting Publications1
PMIDTitleRelated sentences
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No related sentences available