Protein detail

DAB2

Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)

Entry name DAB2	UniProt ID P98082	EVMP confidence score 0.60
Supporting publications (n) 14	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000153071

Entrez Gene Symbol

DAB2

Gene Synonym

DOC-2

Gene Description

DAB adaptor protein 2

Chromosome

Position

39371675-39462300

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization2

Cell SpecificMyonuclei

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (11)

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Molecular Function (5)

Biological Process (3)

KEGG

hsa04144 Endocytosis

Reactome (6)

Canonical Pathways (3)

M266 Pid ncadherin pathway
M142 Pid ajdiss 2pathway
M50 Pid ptp1b pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence41

Enzyme-Mediated Modification (13)

13 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
DAB2	MAPK14	Q16539	S	227	phosphorylation	KEA	KEA:17570479
DAB2	MAPK14	Q16539	S	401	phosphorylation	KEA	KEA:17570479
DAB2	MAPK14	Q16539	T	221	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (12)

12 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCB	P05771	DAB2	P98082	Yes	No	No	BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEACancerCellMapSIGNOR_ProtMapperPhosphoSite_ProtMapper	KEA:11812785 SIGNOR:10542228 CancerCellMap:10542228 KEA:10542228 ProtMapper:10542228 HPRD:10542228
KCC2G	Q13555	DAB2	P98082	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:33557943 PhosphoSite:28876503

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Protein Complex Composition (10)

10 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CLTC CZIB DAB2 EPS15 FCHO1 FCHO2 LRRC59 SLC25A41	O14526 P42566 P98082 Q00610 Q0JRZ9 Q8N5S1 Q96AG4 Q9NWV4	0:0:0:0:0:0:0:0	hu.MAP2
DAB2 EPS15 FCHO1 FCHO2 SLC25A41	O14526 P42566 P98082 Q0JRZ9 Q8N5S1	0:0:0:0:0	hu.MAP2
DAB2 FCHO1 FCHO2 SLC25A41	O14526 P98082 Q0JRZ9 Q8N5S1	0:0:0:0	hu.MAP2
ASNSD1 CADPS CLIP1 DAB2IP IDO2 RFPL1 RFPL2 RFPL3 ZNF410	O75677 O75678 O75679 P30622 Q5VWQ8 Q6ZQW0 Q86VK4 Q9NWL6 Q9ULU8	0:0:0:0:0:0:0:0:0	hu.MAP2
DAB2IP RFPL1 RFPL2 RFPL3	O75677 O75678 O75679 Q5VWQ8	0:0:0:0	hu.MAP
ASNSD1 DAB2IP RFPL1 RFPL2 RFPL3	O75677 O75678 O75679 Q5VWQ8 Q9NWL6	0:0:0:0:0	hu.MAPhu.MAP2
CADPS CLIP1 DAB2IP RFPL1 RFPL3	O75677 O75679 P30622 Q5VWQ8 Q9ULU8	0:0:0:0:0	hu.MAP2
DAB2	P98082	2	PDB	PDB:6o5oPDB:6ovf
DAB2 FCHO2	P98082 Q0JRZ9	0:0	hu.MAP2
DAB2 SLC25A41	P98082 Q8N5S1	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains14

Sequences

Length

770

Mass

82,448

Sequence

MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P98082-1; Sequence=Displayed; Name=2; IsoId=P98082-2; Sequence=VSP_004181; Name=3; IsoId=P98082-3; Sequence=VSP_038401

Alternative Sequence

209..229; Missing (in isoform 3); 230..447; Missing (in isoform 2)

3D Structural Models

Turn

44..46; 107..109

Helix

36..43; 66..85; 118..120; 156..180

Beta Strand

29..31; 48..59; 61..63; 91..98; 101..106; 112..116; 121..126; 133..138; 145..153

3D Structure

NMR spectroscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

1..16; Polar residues; 302..313; Polar residues; 366..396; Polar residues; 407..425; Polar residues; 466..480; Polar residues; 604..616; Polar residues; 745..758; Low complexity

Motif

293..295; DPF 1; 298..300; DPF 2

Domain (CC)

The PID domain binds to predominantly non-phosphorylated NPXY internalization motifs present in members of the LDLR and APP family; it also mediates simultaneous binding to phosphatidylinositol 4,5-bisphosphate.; DOMAIN: The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of EPS15, EPS15R and ITSN1..

Domain (FT)

45..196; PID

Region

1..38; Disordered; 230..447; Required for localization to clathrin-coated pits; 284..482; Disordered; 604..732; Sufficient for interaction with GRB2; 604..629; Disordered; 619..627; Required for interaction with CSK; 649..770; Required for interaction with MYO6; 663..671; Required for interaction with GRB2 and CSK; 709..725; Sufficient for interaction with SH3KBP1 SH3 domain; 742..770; Disordered

Clinical Relevance5

Disease Involvement

Tumor suppressor

Antibody (2)

CAB009314 HPA028888

Interaction Protein (5)

ENSG00000147010ENSG00000166949ENSG00000175387ENSG00000177885ENSG00000196586

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications14

PMID	Title	Abstract
38871730	Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes.	No abstract available
38938674	Gestational age at birth influences protein and RNA content in human milk extracellular vesicles.	No abstract available
39949490	CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available

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