Protein detail
DAB2
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Entry name DAB2 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 14 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DOC-2
Gene Description
DAB adaptor protein 2
Chromosome
5
Position
39371675-39462300
Supporting publications (n)
14
EVMP confidence score
0.60
Fluorescence & Localization2
Cell SpecificMyonuclei
Function & Pathway8
Protein Function
Predicted intracellular proteins
Cellular Component (11)
- GO:0001650 fibrillar center
- GO:0005737 cytoplasm
- GO:0005765 lysosomal membrane
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0005925 focal adhesion
- GO:0030136 clathrin-coated vesicle
- GO:0030665 clathrin-coated vesicle membrane
- GO:0043231 intracellular membrane-bounded organelle
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Molecular Function (5)
Biological Process (3)
Reactome (6)
Canonical Pathways (3)
- M266 Pid ncadherin pathway
- M142 Pid ajdiss 2pathway
- M50 Pid ptp1b pathway
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence41
Enzyme-Mediated Modification (13)
13 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DAB2 | MAPK14 | Q16539 | S | 227 | phosphorylation | KEA | KEA:17570479 |
| DAB2 | MAPK14 | Q16539 | S | 401 | phosphorylation | KEA | KEA:17570479 |
| DAB2 | MAPK14 | Q16539 | T | 221 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (12)
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCB | P05771 | DAB2 | P98082 | Yes | No | No | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEACancerCellMapSIGNOR_ProtMapperPhosphoSite_ProtMapper | KEA:11812785SIGNOR:10542228CancerCellMap:10542228KEA:10542228ProtMapper:10542228HPRD:10542228 |
| KCC2G | Q13555 | DAB2 | P98082 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:33557943PhosphoSite:28876503 |
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Protein Complex Composition (10)
10 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CLTCCZIBDAB2EPS15FCHO1FCHO2LRRC59SLC25A41 | O14526P42566P98082Q00610Q0JRZ9Q8N5S1Q96AG4Q9NWV4 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| DAB2EPS15FCHO1FCHO2SLC25A41 | O14526P42566P98082Q0JRZ9Q8N5S1 | 0:0:0:0:0 | hu.MAP2 | |||
| DAB2FCHO1FCHO2SLC25A41 | O14526P98082Q0JRZ9Q8N5S1 | 0:0:0:0 | hu.MAP2 | |||
| ASNSD1CADPSCLIP1DAB2IPIDO2RFPL1RFPL2RFPL3ZNF410 | O75677O75678O75679P30622Q5VWQ8Q6ZQW0Q86VK4Q9NWL6Q9ULU8 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| DAB2IPRFPL1RFPL2RFPL3 | O75677O75678O75679Q5VWQ8 | 0:0:0:0 | hu.MAP | |||
| ASNSD1DAB2IPRFPL1RFPL2RFPL3 | O75677O75678O75679Q5VWQ8Q9NWL6 | 0:0:0:0:0 | hu.MAPhu.MAP2 | |||
| CADPSCLIP1DAB2IPRFPL1RFPL3 | O75677O75679P30622Q5VWQ8Q9ULU8 | 0:0:0:0:0 | hu.MAP2 | |||
| DAB2 | P98082 | 2 | PDB | PDB:6o5oPDB:6ovf | ||
| DAB2FCHO2 | P98082Q0JRZ9 | 0:0 | hu.MAP2 | |||
| DAB2SLC25A41 | P98082Q8N5S1 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains14
Sequences
Length
770
Mass
82,448
Sequence
MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P98082-1; Sequence=Displayed; Name=2; IsoId=P98082-2; Sequence=VSP_004181; Name=3; IsoId=P98082-3; Sequence=VSP_038401
Alternative Sequence
209..229; Missing (in isoform 3); 230..447; Missing (in isoform 2)
3D Structural Models
Turn
44..46; 107..109
Helix
36..43; 66..85; 118..120; 156..180
Beta Strand
29..31; 48..59; 61..63; 91..98; 101..106; 112..116; 121..126; 133..138; 145..153
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1..16; Polar residues; 302..313; Polar residues; 366..396; Polar residues; 407..425; Polar residues; 466..480; Polar residues; 604..616; Polar residues; 745..758; Low complexity
Motif
293..295; DPF 1; 298..300; DPF 2
Domain (CC)
The PID domain binds to predominantly non-phosphorylated NPXY internalization motifs present in members of the LDLR and APP family; it also mediates simultaneous binding to phosphatidylinositol 4,5-bisphosphate.; DOMAIN: The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of EPS15, EPS15R and ITSN1..
Domain (FT)
45..196; PID
Region
1..38; Disordered; 230..447; Required for localization to clathrin-coated pits; 284..482; Disordered; 604..732; Sufficient for interaction with GRB2; 604..629; Disordered; 619..627; Required for interaction with CSK; 649..770; Required for interaction with MYO6; 663..671; Required for interaction with GRB2 and CSK; 709..725; Sufficient for interaction with SH3KBP1 SH3 domain; 742..770; Disordered
Clinical Relevance5
Supporting Publications14
| PMID | Title | Abstract |
|---|---|---|
| 26538482 | Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles. | No abstract available |
| 30071318 | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33114768 | Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma. | No abstract available |
| 33718342 | Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells. | No abstract available |
| 37033249 | Altered ureido protein modification profiles in seminal plasma extracellular vesicles of non-normozoospermic men. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 37702715 | One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles. | No abstract available |
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | No abstract available |
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