Protein detail

PKD1

Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)

Entry name
PKD1
UniProt ID
P98161
EVMP confidence score
0.35
Supporting publications (n)
0
Transmembrane count
11
Protein classification
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Basic Information
Protein Names
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)
Protein Class (8)
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (6)
  • Predicted intracellular proteins
  • Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
  • Potential drug targets
  • Predicted secreted proteins
  • Transporters:Transporter channels and pores
  • Disease related genes
Transmembrane
3075..3095; Helical; 3278..3298; Helical; 3324..3344; Helical; 3560..3580; Helical; 3583..3603; Helical; 3666..3686; Helical; 3902..3922; Helical; 3936..3956; Helical; 3985..4005; Helical; 4028..4048; Helical; 4091..4110; Helical
Transmembrane Count
11
Ensembl
ENSG00000008710
Entrez Gene Symbol
PKD1
Gene Synonym (3)
PBPPc-1TRPP1
Gene Description
Polycystin 1, transient receptor potential channel interacting
Chromosome
16
Position
2088708-2135898
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytes
Function & Pathway
Protein Function (6)
  • Predicted intracellular proteins
  • Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
  • Potential drug targets
  • Predicted secreted proteins
  • Transporters:Transporter channels and pores
  • Disease related genes
Cellular Component (19)
Page 1 of 2
Molecular Function (9)
Biological Process (3)
Reactome (4)
Canonical Pathways (3)
  • M144 Pid ceramide pathway
  • M128 Pid tnf pathway
  • M220 Pid caspase pathway
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence46

Enzyme-Mediated Modification (8)

8 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PKD1PRKXP51817S4,166phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperdbPTM:17980165ProtMapper:17980165SIGNOR:17980165
PKD1PRKACAP17612S4,252phosphorylationPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
PKD1SRCP12931Y4,237phosphorylationPhosphoSite_MIMPMIMPProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:11274246
PKD1PRKCDQ05655S916phosphorylationREACH_ProtMapperProtMapperProtMapper:21696630
PKD1NTSP30990S744phosphorylationREACH_ProtMapperProtMapperProtMapper:20082306
PKD1IRAK4Q9NWZ3S744phosphorylationREACH_ProtMapperProtMapperProtMapper:28461572
PKD1IRAK4Q9NWZ3S748phosphorylationREACH_ProtMapperProtMapperProtMapper:28461572
PKD1PRKCAP17252S249phosphorylationKEAKEA:10867018

Ligand-Receptor Signaling (31)

31 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorGO_IntercellYesYes
receptorreceptorOmniPathYesYes
extracellularextracellularOmniPathYes
intracellularintracellularComPPIYes
intracellularintracellularGO_IntercellYes
intracellularintracellularUniProt_locationYes
intracellularintracellularOmniPathYes
transportertransporterSurfaceomeYesYes
auxiliary_transport_unittransporterAlmen2009YesYes
auxillarytransportunittransporterSurfaceomeYesYes
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Regulatory Interaction Network (4)

4 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PKD1P98161SIAH1Q8IUQ4YesYesHPRDLit-BM-17SIGNORSIGNOR:23001567Lit-BM-17:15284290HPRD:15284290
PKD1P98161JADE1Q6IE81YesYesSIGNORSIGNOR:23001567
PRKXP51817PKD1P98161YesYesSparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:17980165dbPTM:17980165ProtMapper:17980165SIGNOR:17980165
SRCP12931PKD1P98161YesYesAdhesomeMIMPPhosphoSite_MIMPiPTMnetPhosphoPointProtMapperHPRDRLIMS-P_ProtMapperKinexus_KEAKEAWangPhosphoSitePhosphoSite_ProtMapperPhosphoSite:21126580KEA:12637538ProtMapper:11274246Adhesome:11113628PhosphoSite:10362514HPRD:11113628

Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
BBS1-BBS4-BBS5-PKD1-TTC8 complexBBS1BBS4BBS5PKD1TTC8P98161Q8N3I7Q8NFJ9Q8TAM2Q96RK40:0:0:0:0CORUMCORUM:660124939912
NPHP1-PKD1 complexNPHP1PKD1O15259P981610:0CORUMCORUM:660020856870

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
PRotein Organic Solvent Precipitation；Differential UltracentrifugationMass spectrometry132384937
Sequence, Structure & Domains

Sequences

Length
4,303
Mass
462,529
Sequence
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P98161-1; Sequence=Displayed; Name=2; IsoId=P98161-2; Sequence=VSP_009677, VSP_009678; Name=3; IsoId=P98161-3; Sequence=VSP_009678
Alternative Sequence
2497..2507; GWHDAEDAGAP -> A (in isoform 2); 3390; Missing (in isoform 2 and isoform 3)

3D Structural Models

Beta Strand
276..278; 285..296; 301..306; 313..317; 320..325; 327..338; 343..353
3D Structure
Electron microscopy (9); NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias
4185..4195; Polar residues; 4253..4269; Low complexity; 4292..4303; Basic residues
Repeat
68..91; LRR 1; 92..113; LRR 2
Coiled Coil
4220..4251
Domain (CC)
The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.
Domain (FT)
24..67; LRRNT; 125..178; LRRCT; 177..271; WSC; 272..359; PKD 1; 415..531; C-type lectin; 638..671; LDL-receptor class A; atypical; 743..817; PKD 2; 855..928; PKD 3; 935..1020; PKD 4; 1023..1129; PKD 5; 1127..1215; PKD 6; 1213..1298; PKD 7; 1294..1383; PKD 8; 1382..1469; PKD 9; 1468..1551; PKD 10; 1550..1635; PKD 11; 1634..1721; PKD 12; 1719..1805; PKD 13; 1807..1890; PKD 14; 1889..1974; PKD 15; 1977..2057; PKD 16; 2060..2148; PKD 17; 2146..2833; REJ; 2862..3063; GAIN-B; 3118..3233; PLAT
Region
616..635; Disordered; 3015..3063; GPS; 4160..4196; Disordered; 4243..4303; Disordered
Protein Families
Polycystin family
Sequence Similarities
Belongs to the polycystin family.
Clinical Relevance
Disease Involvement (2)
CiliopathyDisease variant
Antibody
CAB046448
Interaction Protein (2)
ENSG00000118762ENSG00000144061
Interaction Count
2
Interaction Dataset
intact_biogrid