Protein detail
PKD1
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)
Protein symbol PKD1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 11 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Potential drug targets
- Predicted secreted proteins
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
3075..3095; Helical; 3278..3298; Helical; 3324..3344; Helical; 3560..3580; Helical; 3583..3603; Helical; 3666..3686; Helical; 3902..3922; Helical; 3936..3956; Helical; 3985..4005; Helical; 4028..4048; Helical; 4091..4110; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
PBPPc-1TRPP1
Gene Description
Polycystin 1, transient receptor potential channel interacting
Chromosome
16
Position
2088708-2135898
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Potential drug targets
- Predicted secreted proteins
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component
- GO:0000139 Golgi membrane
- GO:0002133 polycystin complex
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005929 cilium
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030660 Golgi-associated vesicle membrane
- GO:0031514 motile cilium
- GO:0034703 cation channel complex
- GO:0034704 calcium channel complex
- GO:0060170 ciliary membrane
- GO:0070062 extracellular exosome
- GO:0140494 migrasome
Molecular Function
- GO:0005261 monoatomic cation channel activity
- GO:0005262 calcium channel activity
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0019904 protein domain specific binding
- GO:0030246 carbohydrate binding
- GO:0042813 Wnt receptor activity
- GO:0044325 transmembrane transporter binding
- GO:0140416 transcription regulator inhibitor activity
Biological Process
Reactome
Canonical Pathways
- M144 Pid ceramide pathway
- M128 Pid tnf pathway
- M220 Pid caspase pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKD1 | PRKX | P51817 | S | 4,166 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:17980165ProtMapper:17980165SIGNOR:17980165 |
| PKD1 | PRKACA | P17612 | S | 4,252 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PKD1 | SRC | P12931 | Y | 4,237 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:11274246 |
| PKD1 | PRKCD | Q05655 | S | 916 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21696630 |
| PKD1 | NTS | P30990 | S | 744 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:20082306 |
| PKD1 | IRAK4 | Q9NWZ3 | S | 744 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28461572 |
| PKD1 | IRAK4 | Q9NWZ3 | S | 748 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28461572 |
| PKD1 | PRKCA | P17252 | S | 249 | phosphorylation | KEA | KEA:10867018 |
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | No | No | Yes | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | No | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | No | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PKD1 | P98161 | SIAH1 | Q8IUQ4 | Yes | Yes | No | HPRDLit-BM-17SIGNOR | SIGNOR:23001567Lit-BM-17:15284290HPRD:15284290 |
| PKD1 | P98161 | JADE1 | Q6IE81 | Yes | No | Yes | SIGNOR | SIGNOR:23001567 |
| PRKX | P51817 | PKD1 | P98161 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:17980165dbPTM:17980165ProtMapper:17980165SIGNOR:17980165 |
| SRC | P12931 | PKD1 | P98161 | Yes | Yes | No | AdhesomeMIMPPhosphoSite_MIMPiPTMnetPhosphoPointProtMapperHPRDRLIMS-P_ProtMapperKinexus_KEAKEAWangPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21126580KEA:12637538ProtMapper:11274246Adhesome:11113628PhosphoSite:10362514HPRD:11113628 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
4,303
Mass
462,529
Sequence
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P98161-1; Sequence=Displayed; Name=2; IsoId=P98161-2; Sequence=VSP_009677, VSP_009678; Name=3; IsoId=P98161-3; Sequence=VSP_009678
Alternative Sequence
2497..2507; GWHDAEDAGAP -> A (in isoform 2); 3390; Missing (in isoform 2 and isoform 3)
3D Structural Models
Beta Strand
276..278; 285..296; 301..306; 313..317; 320..325; 327..338; 343..353
3D Structure
Electron microscopy (9); NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
4185..4195; Polar residues; 4253..4269; Low complexity; 4292..4303; Basic residues
Repeat
68..91; LRR 1; 92..113; LRR 2
Coiled Coil
4220..4251
Domain (CC)
The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.
Domain (FT)
24..67; LRRNT; 125..178; LRRCT; 177..271; WSC; 272..359; PKD 1; 415..531; C-type lectin; 638..671; LDL-receptor class A; atypical; 743..817; PKD 2; 855..928; PKD 3; 935..1020; PKD 4; 1023..1129; PKD 5; 1127..1215; PKD 6; 1213..1298; PKD 7; 1294..1383; PKD 8; 1382..1469; PKD 9; 1468..1551; PKD 10; 1550..1635; PKD 11; 1634..1721; PKD 12; 1719..1805; PKD 13; 1807..1890; PKD 14; 1889..1974; PKD 15; 1977..2057; PKD 16; 2060..2148; PKD 17; 2146..2833; REJ; 2862..3063; GAIN-B; 3118..3233; PLAT
Region
616..635; Disordered; 3015..3063; GPS; 4160..4196; Disordered; 4243..4303; Disordered
Protein Families
Polycystin family
Sequence Similarities
Belongs to the polycystin family.
Clinical Relevance
Disease Involvement
CiliopathyDisease variant
Antibody
Interaction Protein
ENSG00000118762ENSG00000144061
Interaction Count
2
Interaction Dataset
intact_biogrid