Protein detail
AT8B2
Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2)
Protein symbol AT8B2 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 10 | Protein classification EnzymesMetabolic proteinsPredicted membrane proteins |
Basic Information
Protein Names
Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2)
Protein Class
EnzymesMetabolic proteinsPredicted membrane proteins
Protein Function
- Enzymes
- ENZYME proteins
Transmembrane
65..86; Helical; 93..112; Helical; 296..317; Helical; 347..368; Helical; 890..910; Helical; 923..942; Helical; 973..994; Helical; 1009..1031; Helical; 1038..1058; Helical; 1079..1103; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
ATPIDKIAA1137
Gene Description
ATPase phospholipid transporting 8B2
Chromosome
1
Position
154325525-154351304
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificNeutrophils
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M134 Pid tcr ras pathway
- M18895 Sa trka receptor
- M267 Pid anthrax pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,209
Mass
137,440
Sequence
MTVPKEMPEKWARAQAPPSWSRKKPSWGTEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHTHEFFRLLSLCHTVMSEEKNEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYEEVENNMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P98198-1; Sequence=Displayed; Name=2; IsoId=P98198-2; Sequence=VSP_007302, VSP_007303; Name=3; IsoId=P98198-3; Sequence=VSP_037147; Name=4; IsoId=P98198-4; Sequence=VSP_037148, VSP_037149, VSP_037150; Name=5; IsoId=P98198-5; Sequence=VSP_037148
Alternative Sequence
1..29; MTVPKEMPEKWARAQAPPSWSRKKPSWGT -> MDTLRAVPLFSISGLFSFPYRVSHGIAGILLGEMAVCAKKRPP (in isoform 3); 1..29; MTVPKEMPEKWARAQAPPSWSRKKPSWGT -> MAVCAKKRPP (in isoform 4 and isoform 5); 364..406; SVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVE -> RYVPSLTWGLSRESGGPIELFFSMKMKSLRSNEKSSSSCTVNI (in isoform 4); 407..1209; Missing (in isoform 4); 434..461; GDVFDVLGHKAELGERPEPVDFSFNPLA -> VGSEGPRRKGPSWPGTVAHAYSHSTLGG (in isoform 2); 462..1209; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..12; Basic and acidic residues; 1195..1209; Low complexity
Region
1..36; Disordered; 1181..1209; Disordered
Protein Families
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IV subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.