Protein detail
CDK5
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Entry name CDK5 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Protein Class
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- Kinases:CMGC Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
PSSALRE
Gene Description
Cyclin dependent kinase 5
Chromosome
7
Position
151053815-151057897
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNeutrophilsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificbasophil
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- Kinases:CMGC Ser/Thr protein kinases
- Disease related genes
Cellular Component
- GO:0000307 cyclin-dependent protein kinase holoenzyme complex
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005874 microtubule
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0016533 protein kinase 5 complex
- GO:0030027 lamellipodium
- GO:0030054 cell junction
- GO:0030175 filopodium
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0030426 growth cone
- GO:0031594 neuromuscular junction
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043204 perikaryon
- GO:0098793 presynapse
Molecular Function
- GO:0002039 p53 binding
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0004693 cyclin-dependent protein serine/threonine kinase activity
- GO:0005176 ErbB-2 class receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0030549 acetylcholine receptor activator activity
- GO:0043125 ErbB-3 class receptor binding
- GO:0044024 histone H2AS1 kinase activity
- GO:0048156 tau protein binding
- GO:0050321 tau-protein kinase activity
- GO:0051879 Hsp90 protein binding
- GO:0106310 protein serine kinase activity
Biological Process
KEGG
Reactome
- R-hsa-9032845 activated ntrk2 signals through cdk5
- R-hsa-9909396 circadian clock
- R-hsa-399956 crmps in sema3a signaling
- R-hsa-180024 darpp 32 events
- R-hsa-9734009 defective intrinsic pathway for apoptosis
- R-hsa-9645723 diseases of programmed cell death
- R-hsa-9917777 epigenetic regulation by wdr5 containing histone modifying complexes
- R-hsa-212165 epigenetic regulation of gene expression
- R-hsa-9818564 epigenetic regulation of gene expression by mll3 and mll4 complexes
- R-hsa-983231 factors involved in megakaryocyte development and platelet production
- R-hsa-418594 g alpha i signalling events
- R-hsa-109582 hemostasis
- R-hsa-9675108 nervous system development
- R-hsa-9031628 ngf stimulated transcription
- R-hsa-9768919 npas4 regulates expression of target genes
- R-hsa-198725 nuclear events kinase and transcription factor activation
- R-hsa-111885 opioid signalling
- R-hsa-9931529 phosphorylation and nuclear translocation of bmal1 arntl and clock
- R-hsa-9931530 phosphorylation and nuclear translocation of the cry per kinase complex
- R-hsa-5633007 regulation of tp53 activity
- R-hsa-6804756 regulation of tp53 activity through phosphorylation
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-373755 semaphorin interactions
- R-hsa-372790 signaling by gpcr
- R-hsa-9006115 signaling by ntrk2 trkb
- R-hsa-166520 signaling by ntrks
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9634815 transcriptional regulation by npas4
- R-hsa-3700989 transcriptional regulation by tp53
Canonical Pathways
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
23 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CDK5 | ABL1 | P00519 | Y | 15 | phosphorylation | BEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapper | HPRD:19413330ProtMapper:26944284dbPTM:18691976dbPTM:19534553ProtMapper:28646794KEA:9038181HPRD:19901323ProtMapper:15212693dbPTM:19369195ProtMapper:24600352HPRD:16497976KEA:12372285SIGNOR:10896159dbPTM:18083107dbPTM:19413330ProtMapper:24975575ProtMapper:23348931KEA:10896159dbPTM:19690332HPRD:20068231HPRD:12372285KEA:15689152ProtMapper:18794154ProtMapper:10896159phosphoELM:14757045KEA:14757045ProtMapper:19700222HPRD:18691976ProtMapper:29063113 |
| CDK5 | FYN | P06241 | Y | 15 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperREACH_ProtMapper | KEA:10896159HPRD:19413330KEA:14757045ProtMapper:14757045ProtMapper:12372285SIGNOR:14757045HPRD:20068231HPRD:16497976KEA:12372285HPRD:18691976HPRD:12372285KEA:9038181ProtMapper:24872417ProtMapper:20506281ProtMapper:29063113HPRD:19901323 |
| CDK5 | CSNK1D | P48730 | S | 159 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | ProtMapper:10500146SIGNOR:10500146KEA:10500146 |
| CDK5 | PRKCD | Q05655 | T | 77 | phosphorylation | PhosphoSiteSparser_ProtMapperProtMapper | ProtMapper:29511352 |
| CDK5 | CSNK1A1 | P48729 | S | 159 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper | KEA:10500146 |
| CDK5 | CSNK1G2 | P78368 | S | 159 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:10500146 |
| CDK5 | TTBK2 | Q6IQ55 | S | 159 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CDK5 | TTBK1 | Q5TCY1 | S | 159 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CDK5 | VRK1 | Q99986 | S | 159 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CDK5 | VRK2 | Q86Y07 | S | 159 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
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Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
127 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CDK5 | Q00535 | NOTC1 | P46531 | Yes | Yes | No | SIGNOR | SIGNOR:33960694 |
| CDK5 | Q00535 | NR1I2 | O75469 | Yes | No | Yes | SIGNOR | SIGNOR:20553580 |
| CDK5 | Q00535 | ERBB4 | Q15303 | Yes | Yes | No | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | SIGNOR:24142862ProtMapper:24142862 |
| CDK5 | Q00535 | CLIC4 | Q9Y696 | Yes | Yes | No | SIGNORSparser_ProtMapperProtMapper | SIGNOR:30237421ProtMapper:30237421 |
| CDK5 | Q00535 | DREB | Q16643 | Yes | Yes | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24637538PhosphoSite:28319065ProtMapper:23979715PhosphoSite:24637538ProtMapper:30467237PhosphoSite:23979715ProtMapper:25945928SIGNOR:23979715PhosphoSite:30467237 |
| CDK5 | Q00535 | NEB2 | Q96SB3 | Yes | No | Yes | Sparser_ProtMapperSIGNORProtMapperKEAphosphoELM_KEAREACH_ProtMapper | ProtMapper:28634551ProtMapper:15980451KEA:15728359SIGNOR:29786422ProtMapper:29786422 |
| CDK5 | Q00535 | MEF2D | Q14814 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16356933ProtMapper:22661957PhosphoSite:30699340ProtMapper:19812325PhosphoSite:30523159PhosphoSite:16356933ProtMapper:27413575ProtMapper:27199730SIGNOR:19812325ProtMapper:21741404 |
| CDK5 | Q00535 | CTNB1 | P35222 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetRLIMS-P_ProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:26509276PhosphoSite:25961922PhosphoSite:26740630SIGNOR:26509276PhosphoSite:17009320dbPTM:17009320 |
| CDK5 | Q00535 | KALRN | O60229 | Yes | Yes | No | SIGNOR | SIGNOR:18628310 |
| CDK5 | Q00535 | CADH1 | P12830 | Yes | No | Yes | SIGNOR | SIGNOR:22836916 |
Protein Complex Composition
41 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | CDK5CDK5R1 | Q00535Q15078 | 2:2 | SIGNORCompleatComplexPortalPDB | PDB:1ungPDB:3o0gSIGNOR:SIGNOR-C144PDB:7vdpCompleat:HC1957intact:EBI-9009221PDB:7vdsPDB:1unlPDB:7vdqintact:EBI-9633559PDB:7vdrPDB:1unhPDB:1h4l | 18507738147552921729521216039528 |
| Cdc28p/Clb5p complex | CCNA1CCNA2CCNB1CCNB2CCNB3CCNE2CDK1CDK11BCDK2CDK3CDK5 | O95067O96020P06493P14635P20248P21127P24941P78396Q00526Q00535Q8WWL7 | 1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC3400 | 8319908 |
| Cdc28p/Clb6p complex | CCNA1CCNA2CCNB1CCNB2CCNB3CDK1CDK11BCDK2CDK3CDK5 | O95067P06493P14635P20248P21127P24941P78396Q00526Q00535Q8WWL7 | 1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC889 | 8319908 |
| Cdc28p/Cln1p complex | CDK1CDK11BCDK2CDK3CDK5EEF1A1 | P06493P21127P24941P68104Q00526Q00535 | 1:1:1:1:1:1 | Compleat | Compleat:HC2089 | 8319908 |
| Cdk5-c-Abl-Cables complex | ABL1CABLES1CDK5 | P00519Q00535Q8TDN4 | 1:1:1 | Compleat | Compleat:HC2506 | 10896159 |
| Cell cycle kinase complex CDK5 | CCND1CCND3CDK5CDKN1APCNA | P12004P24385P30281P38936Q00535 | 1:1:1:1:1 | CompleatCORUM | Compleat:HC307CORUM:313 | 7903056 |
| Cyclin-dependent protein kinase 5 holoenzyme complexp39 variant | CDK5CDK5R2 | Q00535Q13319 | 1:1 | ComplexPortal | intact:EBI-9633517 | 1850773814755292 |
| HT_DM_Cluster178 | CDK5RAP3DDRGK1UFL1 | O94874Q96HY6Q96JB5 | 1:1:1 | hu.MAPhu.MAP2CompleatComplexPortal | Compleat:HC1438intact:EBI-46450004 | 36121123220365733759503614755292383837853654379938383789 |
| HT_SC_Cluster39 | CCNA1CCNA2CCNB1CCNB2CCNB3CDK1CDK11BCDK2CDK3CDK5CKS1BCKS2EEF1A1 | O95067P06493P14635P20248P21127P24941P33552P61024P68104P78396Q00526Q00535Q8WWL7 | 1:1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC1583 | |
| PCNA complex | CDK4CDK5CDKN1ADHX9PCNARPA1TOP1 | P11387P11802P12004P27694P38936Q00535Q08211 | 1:1:1:1:1:1:1 | Compleat | Compleat:HC1684 | 11254741 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
292
Mass
33,304
Sequence
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q00535-1; Sequence=Displayed; Name=2; Synonyms=CDK5-SV; IsoId=Q00535-2; Sequence=VSP_041948
Alternative Sequence
105..136; Missing (in isoform 2)
3D Structural Models
Turn
24..26; 197..199; 224..226
Helix
46..55; 87..94; 100..119; 129..131; 145..147; 165..167; 170..173; 182..196; 208..219; 228..232; 248..250; 257..266; 271..273; 277..281; 284..286
Beta Strand
4..12; 14..23; 29..36; 40..42; 66..70; 76..81; 84..86; 132..134; 140..142; 287..289
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Domain (FT)
4..286; Protein kinase
Protein Families
- Protein kinase superfamily
- CMGC Ser/Thr protein kinase family
- CDC2/CDKX subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Clinical Relevance
Disease Involvement
LissencephalyNeurodegeneration
Related Diseases
Biomarker
Preclinical
Drugs
GW441756XAZD-1080NULLRGB-286638CHEMBL:CHEMBL1406948HAEMATOXYLINCHEMBL:CHEMBL379975JNJ-7706621KENPAULLONEGO-6976PHA-767491OLOMOUCINELY-2090314PF-562271PP2DECYNIUM 22DINACICLIBSP-600125AZD5438NVP-TAE684PURPUROGALLINPALBOCICLIBCHEMBL:CHEMBL300389(RS)-ROSCOVITINECHEMBL:CHEMBL1276446RONICICLIBALSTERPAULLONESB-415286SOTRASTAURINCHEMBL:CHEMBL261692RG-1530ADAVOSERTIBTAMATINIBSELICICLIBALVOCIDIBFASUDILBAY 61-3606CHEMBL:CHEMBL1997335BMS-387032CYC-116AT-7519PHA-793887CENISERTIBAR-AO-14418
Interaction Protein
ENSG00000105401ENSG00000110092ENSG00000111276ENSG00000112576ENSG00000118816ENSG00000118971ENSG00000124762ENSG00000132646ENSG00000134057ENSG00000134508ENSG00000176749ENSG00000183318
Interaction Count
12
Interaction Dataset
intact_biogrid_bioplexbiogrid_bioplexintact_biogridintact_biogrid_opencell