Protein detail

CDK16

Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)

Entry name CDK16	UniProt ID Q00536	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

Basic Information

Protein Names

Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CMGC Ser/Thr protein kinases

Ensembl

ENSG00000102225

Entrez Gene Symbol

CDK16

Gene Synonym (5)

FLJ16665PCTAIREPCTAIRE1PCTGAIREPCTK1

Gene Description

Cyclin dependent kinase 16

Chromosome

Position

47217860-47229997

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Function & Pathway

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CMGC Ser/Thr protein kinases

Cellular Component (9)

Molecular Function (5)

Biological Process (3)

Canonical Pathways

M76 Pid p38 alpha beta pathway

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence77

Enzyme-Mediated Modification (48)

48 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CDK16	PRKACA	P17612	S	193	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CDK16	PRKACA	P17612	S	227	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CDK16	CDK5	Q00535	S	95	phosphorylation	Sparser_ProtMapperProtMapperHPRDKEAREACH_ProtMapper	HPRD:18691976 HPRD:12084709 KEA:12084709 ProtMapper:21335063
CDK16	CDK5	Q00535	S	101	phosphorylation	HPRD	HPRD:18691976 HPRD:12084709
CDK16	CDK5	Q00535	S	169	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CDK16	BRSK2	Q8IWQ3	S	12	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
CDK16	CDK2	P24941	S	138	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
CDK16	CDK2	P24941	S	169	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CDK16	CDK2	P24941	S	212	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CDK16	CDK1	P06493	S	169	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Receiver
receptor	receptor	OmniPath	Yes
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath
receptor	receptor	scConnect	Yes

Regulatory Interaction Network (8)

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CDK5	Q00535	CDK16	Q00536	Yes	Yes		Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAREACH_ProtMapperHPRD-phos	HPRD-phos:12084709 HPRD:12084709 ProtMapper:21335063 HPRD-phos:18691976 KEA:12084709 HINT:32707033 SIGNOR:12084709 ProtMapper:12084709 HINT:12084709 ProtMapper:18691976
CDK16	Q00536	P53	P04637	Yes		Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapper	ProtMapper:29344296 SIGNOR:29344296
	COMPLEX:Q00536_Q8ND76	CDK16	Q00536	Yes	Yes		SIGNOR	SIGNOR:30992425 SIGNOR:32723157
CDK16	Q00536	NSF	P46459	Yes	Yes	Yes	Sparser_ProtMapperSIGNORProtMapperKEAphosphoELM_KEAWangREACH_ProtMapper	ProtMapper:22796189 KEA:16461345 ProtMapper:26758690 ProtMapper:16461345 ProtMapper:21982980 SIGNOR:16461345
CDK16	Q00536	CDN1B	P46527	Yes		Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperHINTREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:27351680 ProtMapper:25205104 ProtMapper:25790448 SIGNOR:25205104 ProtMapper:29629337 ProtMapper:32086342 HINT:33961781 HINT:34591612
CDK16	Q00536	KAP0	P10644	Yes	Yes		iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:25605337
CDK16	Q00536	PRC1	O43663	Yes	Yes		iPTMnetSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:30992425 SIGNOR:35449080
KAPCA	P17612	CDK16	Q00536	Yes		Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper	PhosphoSite:26305884 PhosphoSite:22798068 HPRD-phos:18669648 HPRD-phos:18767875 SIGNOR:22184064 HPRD-phos:17322306 PhosphoSite:22184064 HPRD-phos:12154078 ProtMapper:22184064 HPRD-phos:20068231 ProtMapper:12154078 ProtMapper:18212344 ProtMapper:18691976 KEA:18691976 ProtMapper:18767875 ProtMapper:19651622 HPRD:12154078 HPRD-phos:18212344 ProtMapper:17322306 PhosphoSite:12154078 HPRD-phos:18691976 ProtMapper:20068231 ProtMapper:18669648 HPRD-phos:19651622 KEA:12154078

Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CyclinY/CDK16	CCNY CDK16	Q00536 Q8ND76	1:1	SIGNORComplexPortal	intact:EBI-11658189SIGNOR:SIGNOR-C540	32098961 14755292 19524571
	CDK16 CDK18 CSNK1E SEC23A SEC24B SEC24D STX5 SURF4 TMED10 TMED2 TMED7 TMED9 UBC YWHAH	O15260 O94855 O95487 P0CG48 P49674 P49755 Q00536 Q04917 Q07002 Q13190 Q15363 Q15436 Q9BVK6 Q9Y3B3	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6492
	CDK16 CDK18 CSNK1E MAST3 SEC23A SEC24B SEC24D UBC YWHAH YWHAQ	O60307 O94855 O95487 P0CG48 P27348 P49674 Q00536 Q04917 Q07002 Q15436	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5835
	CDK16 CDK18 CSNK1E MAST3 SEC23A SEC23B SEC24B SEC24C SEC24D TMED2 UBC YWHAH	O60307 O94855 O95487 P0CG48 P49674 P53992 Q00536 Q04917 Q07002 Q15363 Q15436 Q15437	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3871
	ARHGEF2 CDK14 CDK16 EXO1 FRY HSPA8 NUBP1 PFKFB2 UBC YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	O60825 O94921 P0CG48 P11142 P27348 P31946 P53384 P61981 P62258 P63104 Q00536 Q04917 Q5TBA9 Q92974 Q9UQ84	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6872
	CCNK CDK16 CDK18 SEC23A SEC23B SEC24B SEC24C SEC24D TMED2 TRIM13 UBC ZFYVE1	O60858 O75909 O94855 O95487 P0CG48 P53992 Q00536 Q07002 Q15363 Q15436 Q15437 Q9HBF4	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7175
	AKAP13 ARHGEF2 CDK14 CDK16 DNAJB9 EXO1 MAP3K5 UBC YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	O94921 P0CG48 P27348 P31946 P61981 P62258 P63104 Q00536 Q04917 Q12802 Q92974 Q99683 Q9UBS3 Q9UQ84	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6858
	BRCA1 CDK16 CDK17 CILK1	P38398 Q00536 Q00537 Q9UPZ9	0:0:0:0	hu.MAP
	CDK16	Q00536	2	PDB	PDB:5g6v
	CDK16 CDK18 CILK1	Q00536 Q07002 Q9UPZ9	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

496

Mass

55,716

Sequence

MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q00536-1; Sequence=Displayed; Name=2; IsoId=Q00536-2; Sequence=VSP_046134; Name=3; IsoId=Q00536-3; Sequence=VSP_046342

Alternative Sequence

1; M -> MPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAM (in isoform 2); 1; M -> MQSEIAM (in isoform 3)

3D Structural Models

Turn

185..187; 254..256; 324..327; 330..335; 383..385

Helix

206..217; 247..253; 260..279; 289..291; 342..357; 367..378; 389..391; 393..397; 408..411; 417..426; 431..433; 437..441; 444..449; 452..455; 462..465

Beta Strand

165..173; 175..184; 190..197; 226..231; 233..241; 244..246; 282..286; 292..294; 300..302; 304..309

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

69..78; Basic and acidic residues; 83..93; Polar residues

Domain (FT)

165..446; Protein kinase

Region

1..97; Disordered

Protein Families (3)

Protein kinase superfamily
CMGC Ser/Thr protein kinase family
CDC2/CDKX subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Clinical Relevance

Drugs (5)

RONICICLIB PHA-793887 AT-7519 AZD5438 HESPERADIN

Antibody (3)

HPA000974 HPA001366 CAB016535

Interaction Protein (5)

ENSG00000108100ENSG00000108953ENSG00000123374ENSG00000163249ENSG00000170027

Interaction Count

Interaction Dataset (3)

intact_biogridbiogrid_bioplexintact_biogrid_bioplex

Supporting Publications1

PMID	Title	Related sentences
36189227	Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins.	Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins.