Protein detail

ILRL1

Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)

Protein symbol ILRL1	UniProt ID Q01638	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification Candidate cardiovascular disease genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)

Protein Class

Candidate cardiovascular disease genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted intracellular proteins
Candidate cardiovascular disease genes
Enzymes
Predicted secreted proteins
ENZYME proteins:Hydrolases

Transmembrane

329..349; Helical

Transmembrane Count

Ensembl

ENSG00000115602

Entrez Gene Symbol

IL1RL1

Gene Synonym

DER4FIT-1IL33RST2ST2LST2VT1

Gene Description

Interleukin 1 receptor like 1

Chromosome

Position

102311502-102352037

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway

Protein Function

Predicted intracellular proteins
Candidate cardiovascular disease genes
Enzymes
Predicted secreted proteins
ENZYME proteins:Hydrolases

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

67 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
interleukin	receptor	HGNC	No	Yes	Yes	Yes	No
tir_domain	receptor	HGNC	No	Yes	Yes	Yes	No
receptor	receptor	HGNC	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

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Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ILRL1	Q01638	IL1AP	Q9NPH3	Yes	Yes	No	InnateDBSIGNOR	SIGNOR:35238669 InnateDB:19836339
IL33	O95760	ILRL1	Q01638	Yes	Yes	No	Guide2PharmaCellTalkDBUniProt_LRdbSIGNORconnectomeDB2020HPRDHINTBaccin2019InnateDBDIPSPIKE_LCLRdb	CellTalkDB:23980170 connectomeDB2020:20926795 SPIKE_LC:17145710 InnateDB:18450470 SPIKE_LC:16286016 connectomeDB2020:16286016 SIGNOR:16286016 HPRD:16286016 HINT:23980170 HINT:19439663 DIP:19439663 HINT:16286016 InnateDB:19439663 InnateDB:23980170 connectomeDB2020:19996325 HINT:19559631 InnateDB:19559631 Baccin2019:29247993 connectomeDB2020:29763370 InnateDB:19836339
ILRL1	Q01638	TRAF6	Q9Y4K3	Yes	Yes	No	SPIKE_LCSIGNOR	SPIKE_LC:16286016 SPIKE_LC:17145710 SIGNOR:16286016
ILRL1	Q01638	M3K7	O43318	Yes	Yes	No	SIGNOR	SIGNOR:35238669
ILRL1	Q01638	IRAK4	Q9NWZ3	Yes	Yes	No	InnateDBHINTSIGNORSPIKE_LC	HINT:15084582 InnateDB:12538665 SPIKE_LC:17145710 HINT:12538665 SIGNOR:16286016 HINT:16286016 InnateDB:16286016 InnateDB:15084582
ILRL1	Q01638	IRAK1	P51617	Yes	Yes	No	SIGNOR	SIGNOR:16286016
ILRL1	Q01638	MYD88	Q99836	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	SPIKE_LC:17145710 SIGNOR:16286016 HPRD:15004556

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL33 receptor-ligand complex	IL1RAP IL1RL1 IL33	O95760 Q01638 Q9NPH3	1:1:1	ComplexPortal	PDB:4KC3	27091974 14755292 23980170 27640624
IL33-IL1RL1 decoy complex	IL1RL1 IL33	O95760 Q01638	1:1	ComplexPortalPDB	PDB:4kc3	27091974 14755292 23980170 27640624
IL33_receptor	IL1RAP IL1RL1	Q01638 Q9NPH3	1:1	Guide2PharmaCellChatDBCellPhoneDBICELLNETCellinker	CellPhoneDB:IL33_receptor	24332029 20959797

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

556

Mass

63,358

Sequence

MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=A; Synonyms=ST2L; IsoId=Q01638-1; Sequence=Displayed; Name=B; Synonyms=ST2S; IsoId=Q01638-2; Sequence=VSP_002666, VSP_002667; Name=C; Synonyms=ST2V; IsoId=Q01638-3; Sequence=VSP_002664, VSP_002665; Name=4; IsoId=Q01638-4; Sequence=VSP_054933, VSP_002666, VSP_002667

Alternative Sequence

1..117; Missing (in isoform 4); 204..259; DEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKIT -> VWCQSFCKLKKSLIFSNTHWIQSLMRGFVMVYYGVHKCCRVVFNLCLQYFQHHQWP (in isoform C); 260..556; Missing (in isoform C); 324..328; IDHHS -> SKECF (in isoform B and isoform 4); 329..556; Missing (in isoform B and isoform 4)

3D Structural Models

Turn

156..158

Helix

79..81; 136..138; 173..175; 295..297

Beta Strand

24..27; 32..35; 44..49; 63..68; 71..76; 83..90; 95..105; 121..123; 125..127; 130..132; 146..149; 159..162; 165..170; 177..189; 191..202; 209..216; 219..221; 234..242; 248..253; 265..269; 281..288; 301..306; 311..317

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)

The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Domain (FT)

19..103; Ig-like C2-type 1; 114..197; Ig-like C2-type 2; 212..319; Ig-like C2-type 3; 375..535; TIR

Region

198..211; Flexible linker

Protein Families

Interleukin-1 receptor family

Sequence Similarities

Belongs to the interleukin-1 receptor family.

Clinical Relevance

Related Diseases

Asthma Chronic obstructive pulmonary disease

Biomarker

Phase 2; Phase 3

Drugs

ASTEGOLIMAB

Antibody

HPA007406 HPA007917