Protein detail
LAT1
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Entry name LAT1 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 67 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
50..70; Helical; 84..104; Helical; 127..147; Helical; 170..190; Helical; 193..214; Helical; 243..263; Helical; 277..297; Helical; 325..345; Helical; 370..390; Helical; 396..416; Helical; 431..451; Helical; 458..478; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
CD98D16S469EE16LAT1MPE16
Gene Description
Solute carrier family 7 member 5
Chromosome
16
Position
87830023-87869507
Supporting publications (n)
67
EVMP confidence score
0.88
Fluorescence & Localization5
Tissue Specificendometrium 1Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificmammillary bodySecretome LocationSecreted in other tissuesSecretome FunctionNo annotated function
Function & Pathway8
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (12)
- GO:0005765 lysosomal membrane
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009925 basal plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0031528 microvillus membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
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Molecular Function (10)
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015173 aromatic amino acid transmembrane transporter activity
- GO:0015175 neutral L-amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015190 L-leucine transmembrane transporter activity
- GO:0015196 L-tryptophan transmembrane transporter activity
- GO:0015297 antiporter activity
- GO:0015349 thyroid hormone transmembrane transporter activity
- GO:0042605 peptide antigen binding
Biological Process (3)
Reactome (8)
- R-hsa-210991 basigin interactions
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-109582 hemostasis
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958863 slc mediated transport of amino acids
- R-hsa-382551 transport of small molecules
- R-hsa-71240 tryptophan catabolism
Canonical Pathways
M12705 Sig cd40pathwaymap
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence34
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| slc | transporter | Surfaceome | No | Yes | Yes | Yes | No |
| transporter | transporter | OmniPath | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Ultracentrifugation | Flow cytometry | 1 | 37862381 |
Sequence, Structure & Domains11
Sequences
Length
507
Mass
55,010
Sequence
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
3D Structural Models
Turn
115..117; 157..160; 229..235; 237..239; 253..258; 260..265; 368..370; 473..476
Helix
52..63; 67..70; 72..79; 82..109; 118..124; 127..138; 140..156; 168..188; 190..219; 240..242; 244..252; 270..273; 275..297; 302..306; 311..319; 326..355; 374..386; 387..389; 394..396; 397..421; 435..450; 455..465; 468..472; 483..500
Beta Strand
64..66; 161..164; 224..226; 266..269; 321..323; 363..366
3D Structure
Electron microscopy (21)
Domain & Motif Annotations
Compositional Bias
1..10; Basic residues; 16..27; Basic and acidic residues
Region
1..40; Disordered
Protein Families (2)
- Amino acid-polyamine-organocation (APC) superfamily
- L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Sequence Similarities
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Clinical Relevance6
Drug Targets
Literature-reported target
Drugs (2)
Interaction Protein
ENSG00000168003
Interaction Count
1
Interaction Dataset
intact_biogrid_opencell
Supporting Publications66
| PMID | Title | Abstract |
|---|---|---|
| 38937789 | The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages. | No abstract available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No abstract available |
| 39022990 | Placenta-derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks. | No abstract available |
| 39436214 | Human ovarian extracellular vesicles proteome from polycystic ovary syndrome patients associate with follicular development alterations. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 39940785 | Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer. | No abstract available |
| 39949490 | CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No abstract available |
| 40344445 | Immunosuppressive Effects of Multiple Myeloma-Derived Extracellular Vesicles Through T Cell Exhaustion. | No abstract available |