Protein detail
LAT1
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Entry name LAT1 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 67 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
50..70; Helical; 84..104; Helical; 127..147; Helical; 170..190; Helical; 193..214; Helical; 243..263; Helical; 277..297; Helical; 325..345; Helical; 370..390; Helical; 396..416; Helical; 431..451; Helical; 458..478; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
CD98D16S469EE16LAT1MPE16
Gene Description
Solute carrier family 7 member 5
Chromosome
16
Position
87830023-87869507
Supporting publications (n)
67
EVMP confidence score
0.88
Fluorescence & Localization5
Tissue Specificendometrium 1Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificmammillary bodySecretome LocationSecreted in other tissuesSecretome FunctionNo annotated function
Function & Pathway8
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (12)
- GO:0005765 lysosomal membrane
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009925 basal plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0031528 microvillus membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
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Molecular Function (10)
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015173 aromatic amino acid transmembrane transporter activity
- GO:0015175 neutral L-amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015190 L-leucine transmembrane transporter activity
- GO:0015196 L-tryptophan transmembrane transporter activity
- GO:0015297 antiporter activity
- GO:0015349 thyroid hormone transmembrane transporter activity
- GO:0042605 peptide antigen binding
Biological Process (3)
Reactome (8)
- R-hsa-210991 basigin interactions
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-109582 hemostasis
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958863 slc mediated transport of amino acids
- R-hsa-382551 transport of small molecules
- R-hsa-71240 tryptophan catabolism
Canonical Pathways
M12705 Sig cd40pathwaymap
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence34
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| apical_cell_membrane | plasma_membrane | Ramilowski_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | Cellinker | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| receptor | receptor | scConnect | No | Yes | Yes | Yes | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Ultracentrifugation | Flow cytometry | 1 | 37862381 |
Sequence, Structure & Domains11
Sequences
Length
507
Mass
55,010
Sequence
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
3D Structural Models
Turn
115..117; 157..160; 229..235; 237..239; 253..258; 260..265; 368..370; 473..476
Helix
52..63; 67..70; 72..79; 82..109; 118..124; 127..138; 140..156; 168..188; 190..219; 240..242; 244..252; 270..273; 275..297; 302..306; 311..319; 326..355; 374..386; 387..389; 394..396; 397..421; 435..450; 455..465; 468..472; 483..500
Beta Strand
64..66; 161..164; 224..226; 266..269; 321..323; 363..366
3D Structure
Electron microscopy (21)
Domain & Motif Annotations
Compositional Bias
1..10; Basic residues; 16..27; Basic and acidic residues
Region
1..40; Disordered
Protein Families (2)
- Amino acid-polyamine-organocation (APC) superfamily
- L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Sequence Similarities
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Clinical Relevance6
Drug Targets
Literature-reported target
Drugs (2)
Interaction Protein
ENSG00000168003
Interaction Count
1
Interaction Dataset
intact_biogrid_opencell
Supporting Publications66
| PMID | Title | Abstract |
|---|---|---|
| 28242843 | Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. | No abstract available |
| 28369848 | End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles. | No abstract available |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |
| 28476099 | Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer. | Density gradient centrifugation revealed the co-presence of GGT1 subunits with CD9 in exosomes isolated by differential centrifugation from human serum. In cell lysates and exosomes, GGT1 expression correlated with GGT activity. Since GGT activity correlated with GGT1 expression in serum exosomes isolated by differential centrifugation, we measured serum exosomal GGT activity in patients. The levels of both GGT1 large and small subunits were elevated in exosomes isolated from C4-2 and C4-2B cells by differential centrifugation and by immunocapture with anti-CD9 or -prostate-specific membrane antigen (PSMA) antibody. |
| 28963552 | Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells. | No abstract available |
| 29242380 | Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers. | No abstract available |
| 30353492 | Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways. | No abstract available |
| 30382917 | Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles. | No abstract available |
| 30451371 | Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance. | No abstract available |
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |