Protein detail
AT2B2
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
Entry name AT2B2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 10 | Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
Protein Class (8)
Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (6)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
95..115; Helical; 153..173; Helical; 391..410; Helical; 444..461; Helical; 876..895; Helical; 906..926; Helical; 947..969; Helical; 988..1009; Helical; 1029..1050; Helical; 1061..1082; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
PMCA2
Gene Description
ATPase plasma membrane Ca2+ transporting 2
Chromosome
3
Position
10324023-10708007
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway8
Protein Function (6)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (13)
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0032591 dendritic spine membrane
- GO:0032809 neuronal cell body membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0048787 presynaptic active zone membrane
- GO:0070062 extracellular exosome
- GO:0098688 parallel fiber to Purkinje cell synapse
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Molecular Function (10)
- GO:0005388 P-type calcium transporter activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0030165 PDZ domain binding
- GO:0035254 glutamate receptor binding
- GO:0046872 metal ion binding
- GO:1905059 P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Biological Process (3)
KEGG (9)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa04978 Mineral absorption
Reactome (13)
- R-hsa-5576891 cardiac conduction
- R-hsa-109582 hemostasis
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-397014 muscle contraction
- R-hsa-418360 platelet calcium homeostasis
- R-hsa-418346 platelet homeostasis
- R-hsa-418359 reduction of cytosolic ca levels
- R-hsa-9709957 sensory perception
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Canonical Pathways (3)
- M45 Pid cd40 pathway
- M193 Pid nephrin neph1 pathway
- M23 Pid wnt noncanonical pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence3
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ATP2B2 | PRKCA | P17252 | T | 1,139 | phosphorylation | MIMPHPRD_MIMPKEAPhosphoSite_MIMP | KEA:1827443 |
Ligand-Receptor Signaling (1)
1 record.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains11
Sequences
Length
1,243
Mass
136,876
Sequence
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
Alternative Sequence
303..347; Missing (in isoform ZA and isoform ZB); 304..334; Missing (in isoform XA and isoform XB); 334..347; Missing (in isoform YA and isoform YB); 1141..1243; IRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL -> IEVVNTFKSGASFQGALRRQSSVTSQSQDVANLSSPSRVSLSNALSSPTSLPPAAAGQG (in isoform WA, isoform XA, isoform YA and isoform ZA)
3D Structural Models
Turn
1087..1089; 1090..1092
Helix
1093..1102
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
1..13; Polar residues; 1196..1211; Low complexity; 1220..1234; Low complexity
Region
294..318; Disordered; 1086..1103; Calmodulin-binding subdomain A; 1104..1113; Calmodulin-binding subdomain B
Protein Families (2)
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIB subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
Clinical Relevance4
Disease Involvement (4)
DeafnessDisease variantFDA approved drug targetsNon-syndromic deafness
Drug Targets
FDA approved drug targets
Drugs (34)
PYRAZOLOPYRIMIDINE 4NLYSOPHOSPHATIDYLCHOLINEML9GSMTX-4BTDMGSK2332255BAM-0883DS88790512ACAAAM-147320-HETEOPTOBI-1GSK1702934AGSK2833503ACLEMIZOLEPYRAZOLO-PYRIMIDINE 14A [PMID: 29859875]2-APBOAGARACHIDONIC ACIDGSK417651ALA3+SH045KB-R7943SAR 7334.00LARIXYL ACETATEOPTODARGHYP 9SLGSAGBI 749327FLUFENAMATEH+NORGESTIMATEHYPERFORIN
Antibody