Protein detail
AT2B2
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
Protein symbol AT2B2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 10 | Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
Protein Class
Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
95..115; Helical; 153..173; Helical; 391..410; Helical; 444..461; Helical; 876..895; Helical; 906..926; Helical; 947..969; Helical; 988..1009; Helical; 1029..1050; Helical; 1061..1082; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
PMCA2
Gene Description
ATPase plasma membrane Ca2+ transporting 2
Chromosome
3
Position
10324023-10708007
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0032591 dendritic spine membrane
- GO:0032809 neuronal cell body membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0048787 presynaptic active zone membrane
- GO:0070062 extracellular exosome
- GO:0098688 parallel fiber to Purkinje cell synapse
- GO:0098839 postsynaptic density membrane
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
Molecular Function
- GO:0005388 P-type calcium transporter activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0030165 PDZ domain binding
- GO:0035254 glutamate receptor binding
- GO:0046872 metal ion binding
- GO:1905059 P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa04978 Mineral absorption
Reactome
- R-hsa-5576891 cardiac conduction
- R-hsa-109582 hemostasis
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-397014 muscle contraction
- R-hsa-418360 platelet calcium homeostasis
- R-hsa-418346 platelet homeostasis
- R-hsa-418359 reduction of cytosolic ca levels
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M45 Pid cd40 pathway
- M193 Pid nephrin neph1 pathway
- M23 Pid wnt noncanonical pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ATP2B2 | PRKCA | P17252 | T | 1,139 | phosphorylation | MIMPHPRD_MIMPKEAPhosphoSite_MIMP | KEA:1827443 |
Ligand-Receptor Signaling
1 record.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,243
Mass
136,876
Sequence
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
Alternative Sequence
303..347; Missing (in isoform ZA and isoform ZB); 304..334; Missing (in isoform XA and isoform XB); 334..347; Missing (in isoform YA and isoform YB); 1141..1243; IRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL -> IEVVNTFKSGASFQGALRRQSSVTSQSQDVANLSSPSRVSLSNALSSPTSLPPAAAGQG (in isoform WA, isoform XA, isoform YA and isoform ZA)
3D Structural Models
Turn
1087..1089; 1090..1092
Helix
1093..1102
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
1..13; Polar residues; 1196..1211; Low complexity; 1220..1234; Low complexity
Region
294..318; Disordered; 1086..1103; Calmodulin-binding subdomain A; 1104..1113; Calmodulin-binding subdomain B
Protein Families
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIB subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
Clinical Relevance
Disease Involvement
DeafnessDisease variantFDA approved drug targetsNon-syndromic deafness
Drug Targets
FDA approved drug targets
Drugs
PYRAZOLOPYRIMIDINE 4NLYSOPHOSPHATIDYLCHOLINEML9GSMTX-4BTDMGSK2332255BAM-0883DS88790512ACAAAM-147320-HETEOPTOBI-1GSK1702934AGSK2833503ACLEMIZOLEPYRAZOLO-PYRIMIDINE 14A [PMID: 29859875]2-APBOAGARACHIDONIC ACIDGSK417651ALA3+SH045KB-R7943SAR 7334.00LARIXYL ACETATEOPTODARGHYP 9SLGSAGBI 749327FLUFENAMATEH+NORGESTIMATEHYPERFORIN
Antibody