Protein detail

ROR2

Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)

Entry name ROR2	UniProt ID Q01974	EVMP confidence score 0.50
Supporting publications (n) 7	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)

Protein Function (7)

Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Transmembrane

404..424; Helical

Transmembrane Count

Ensembl

ENSG00000169071

Entrez Gene Symbol

ROR2

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificBreast lactating cells

Function & Pathway

Protein Function (7)

Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component (9)

Molecular Function (7)

Biological Process (3)

KEGG

hsa04310 Wnt signaling pathway

Reactome (4)

Canonical Pathways (3)

M209 Pid p38 gamma delta pathway
M69 Pid reelin pathway
M87 Pid lkb1 pathway

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence77

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ROR2	GSK3B	P49841	S	864	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:21078818 SIGNOR:21078818
ROR2	APC	P25054	S	864	phosphorylation	SIGNOR	SIGNOR:21078818
ROR2	AXIN1	O15169	S	864	phosphorylation	SIGNOR	SIGNOR:21078818

Ligand-Receptor Signaling (62)

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_sosui	transmembrane_predicted	Almen2009				Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009				Yes

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Regulatory Interaction Network (10)

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
WNT5A	P41221	ROR2	Q01974	Yes	Yes		iTALKICELLNETSIGNORProtMapperSignaLink3HPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019WangRamilowski2015CellPhoneDBReactome_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbSparser_ProtMapperNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	ICELLNET:16602827 SIGNOR:26690702 SPIKE_LC:21069266 ProtMapper:22017973 SPIKE_LC:12839624 LRdb:12839624 SPIKE:12839624 SPIKE:20215527 SPIKE_LC:20215527 HPRD:12839624 Baccin2019:12839624 SignaLink3:17203201 SignaLink3:23331499 connectomeDB2020:12839624 Cellinker:18606138 CellTalkDB:12839624 SPIKE:21069266 NetPath:12839624
ROR2	Q01974	FLNA	P21333	Yes	Yes		SPIKESPIKE_LCSIGNOR	SPIKE_LC:20359892 SIGNOR:18667433 SPIKE:20359892
ROR2	Q01974	MAGD1	Q9Y5V3	Yes	Yes		PhosphoPointHPRDSignaLink3SPIKE_LCSPIKE	HPRD:12754255 SignaLink3:12754255 SPIKE_LC:12754255 SPIKE_LC:16713569 SignaLink3:23331499 SPIKE:12754255 SPIKE:16713569
ROR2	Q01974	BMR1B	O00238	Yes	Yes		SignaLink3	SignaLink3:15569154 SignaLink3:23331499
KC1E	P49674	ROR2	Q01974	Yes	Yes		SIGNORSignaLink3	SignaLink3:18848778 SIGNOR:15375164 SignaLink3:23331499
ROR2	Q01974	ARBK1	P25098	Yes	Yes		SignaLink3	SignaLink3:18848778 SignaLink3:23331499
TAB1	Q15750	ROR2	Q01974	Yes		Yes	SIGNOR	SIGNOR:18762249
GSK3B	P49841	ROR2	Q01974	Yes		Yes	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:21078818 SIGNOR:21078818
ROR2	Q01974	MK08	P45983	Yes	Yes		WangSIGNOR	SIGNOR:18667433
	COMPLEX:O15169_P25054_P49841	ROR2	Q01974	Yes		Yes	SIGNOR	SIGNOR:21078818

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ROR2	Q01974	2	PDB	PDB:3zzwPDB:4gt4

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

943

Mass

104,757

Sequence

MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA

3D Structural Models

Turn

262..264; 352..354; 687..689; 692..695

Helix

183..186; 198..216; 221..235; 253..261; 265..273; 275..278; 286..288; 295..297; 307..309; 311..313; 356..358; 368..370; 470..472; 518..530; 561..566; 589..608; 618..620; 625..627; 639..644; 656..658; 661..666; 671..686; 698..706; 719..728; 733..735; 739..747

Beta Strand

174..176; 190..192; 194..197; 279..281; 344..346; 372..381; 385..389; 473..481; 486..492; 502..508; 539..543; 545..548; 550..554; 621..623; 629..631; 648..652

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

765..791; Low complexity; 857..872; Low complexity; 873..883; Polar residues

Domain (FT)

55..145; Ig-like C2-type; 169..303; FZ; 316..394; Kringle; 473..746; Protein kinase

Region

757..796; Disordered; 850..931; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
ROR subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Clinical Relevance

Related Diseases (2)

Metastatic lymph node neoplasm Renal cell carcinoma

Biomarker

Phase 2; Phase 1/2

Drugs

NULL

Interaction Protein (4)

ENSG00000100324ENSG00000120149ENSG00000183283ENSG00000204525

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_bioplex

Supporting Publications7

PMID	Title	Related sentences
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No related sentences available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No related sentences available
39873726	Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.	No related sentences available
41201090	Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma.	No related sentences available