Protein detail
RHD
Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)
Entry name RHD | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 11 | Protein classification Blood group antigen proteinsCD markersDisease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)
Protein Class (6)
Blood group antigen proteinsCD markersDisease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Blood group antigen proteins
- CD markers
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
12..32; Helical; 44..64; Helical; 77..97; Helical; 107..127; Helical; 130..150; Helical; 167..187; Helical; 203..223; Helical; 238..258; Helical; 287..307; Helical; 334..354; Helical; 358..378; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
CD240DDIIIcRHRh30aRh4RhIIRhPI
Gene Description
Rh blood group D antigen
Chromosome
1
Position
25272393-25330445
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (5)
- Blood group antigen proteins
- CD markers
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component
Molecular Function (2)
Biological Process (3)
Reactome (2)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence12
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 39195200 |
Sequence, Structure & Domains
Sequences
Length
417
Mass
45,211
Sequence
MSSKYPRSVRRCLPLWALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAIGLGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPSGKVVITLFSIRLATMSALSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAYFGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISKTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Long; IsoId=Q02161-1; Sequence=Displayed; Name=2; Synonyms=Short 1; IsoId=Q02161-2; Sequence=VSP_005706; Name=3; Synonyms=Short 2; IsoId=Q02161-3; Sequence=VSP_005707, VSP_005708; Name=4; IsoId=Q02161-4; Sequence=VSP_047797; Name=5; IsoId=Q02161-5; Sequence=VSP_047796; Name=6; IsoId=Q02161-6; Sequence=VSP_047795, VSP_047798
Alternative Sequence
314..409; Missing (in isoform 2); 314..378; GCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIAL -> DWLPGPPQHWGTQLGHRDSSHVWSPDSFLIWLLDFKQKHPRKTRPVQKQDNFLSLLPAFVREKRS (in isoform 6); 316; C -> S (in isoform 3); 317..417; Missing (in isoform 3); 358..417; MIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF -> IFLIWLLDFKQKHPRKTRPVQKQDNFLSLLPAFVREKRS (in isoform 5); 359..417; IGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF -> SLGWNLAVKMAEAGDEELMRLDVSQRNHGGAAVPTGSWMPSTETTIAPNYRDHISVVSSFGCWILSKSIQEKQGLFKNKTTSSHCCLHLYVRNAHDSKVSNVRAGTGVRENGVESFLCHSLRRISPFIMHCRIQQ (in isoform 4); 379..417; Missing (in isoform 6)
Domain & Motif Annotations
Protein Families (2)
- Ammonium transporter (TC 2.A.49) family
- Rh subfamily
Sequence Similarities
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 2/3
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |