Protein detail

RHD

Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)

Entry name RHD	UniProt ID Q02161	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 11	Protein classification Blood group antigen proteinsCD markersDisease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)

Protein Class (6)

Blood group antigen proteinsCD markersDisease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (5)

Blood group antigen proteins
CD markers
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Transmembrane

12..32; Helical; 44..64; Helical; 77..97; Helical; 107..127; Helical; 130..150; Helical; 167..187; Helical; 203..223; Helical; 238..258; Helical; 287..307; Helical; 334..354; Helical; 358..378; Helical

Transmembrane Count

Ensembl

ENSG00000187010

Entrez Gene Symbol

RHD

Gene Synonym (7)

CD240DDIIIcRHRh30aRh4RhIIRhPI

Gene Description

Rh blood group D antigen

Chromosome

Position

25272393-25330445

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway6

Protein Function (5)

Blood group antigen proteins
CD markers
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

Reactome (2)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence12

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LAP3 PTRHD1	P28838 Q6GMV3	0:0	hu.MAP
	LAP3 PTRHD1 ZCCHC17	P28838 Q6GMV3 Q9NP64	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	1	39195200

Sequence, Structure & Domains7

Sequences

Length

417

Mass

45,211

Sequence

MSSKYPRSVRRCLPLWALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAIGLGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPSGKVVITLFSIRLATMSALSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAYFGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISKTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Long; IsoId=Q02161-1; Sequence=Displayed; Name=2; Synonyms=Short 1; IsoId=Q02161-2; Sequence=VSP_005706; Name=3; Synonyms=Short 2; IsoId=Q02161-3; Sequence=VSP_005707, VSP_005708; Name=4; IsoId=Q02161-4; Sequence=VSP_047797; Name=5; IsoId=Q02161-5; Sequence=VSP_047796; Name=6; IsoId=Q02161-6; Sequence=VSP_047795, VSP_047798

Alternative Sequence

314..409; Missing (in isoform 2); 314..378; GCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIAL -> DWLPGPPQHWGTQLGHRDSSHVWSPDSFLIWLLDFKQKHPRKTRPVQKQDNFLSLLPAFVREKRS (in isoform 6); 316; C -> S (in isoform 3); 317..417; Missing (in isoform 3); 358..417; MIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF -> IFLIWLLDFKQKHPRKTRPVQKQDNFLSLLPAFVREKRS (in isoform 5); 359..417; IGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF -> SLGWNLAVKMAEAGDEELMRLDVSQRNHGGAAVPTGSWMPSTETTIAPNYRDHISVVSSFGCWILSKSIQEKQGLFKNKTTSSHCCLHLYVRNAHDSKVSNVRAGTGVRENGVESFLCHSLRRISPFIMHCRIQQ (in isoform 4); 379..417; Missing (in isoform 6)

Domain & Motif Annotations

Protein Families (2)

Ammonium transporter (TC 2.A.49) family
Rh subfamily

Sequence Similarities

Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.

Clinical Relevance4

Related Diseases

Anemia

Biomarker

Phase 2/3

Drugs (4)

ROLEDUMAB ROZROLIMUPAB MOROLIMUMAB ATOROLIMUMAB

Antibody (2)

HPA060951 HPA077385

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available