Protein detail

RHD

Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)

Entry name
RHD
UniProt ID
Q02161
EVMP score
0.50
Frequency
1
Transmembrane count
11
Protein classification
Blood group antigen proteinsCD markersDisease related genesPotential drug targetsPredicted membrane proteinsTransporters
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)
Protein Class
Blood group antigen proteinsCD markersDisease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
  • Blood group antigen proteins
  • CD markers
  • Potential drug targets
  • Transporters:Transporter channels and pores
  • Disease related genes
Transmembrane
12..32; Helical; 44..64; Helical; 77..97; Helical; 107..127; Helical; 130..150; Helical; 167..187; Helical; 203..223; Helical; 238..258; Helical; 287..307; Helical; 334..354; Helical; 358..378; Helical
Transmembrane Count
11
Ensembl
ENSG00000187010
Entrez Gene Symbol
RHD
Gene Synonym
CD240DDIIIcRHRh30aRh4RhIIRhPI
Gene Description
Rh blood group D antigen
Chromosome
1
Position
25272393-25330445
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
  • Blood group antigen proteins
  • CD markers
  • Potential drug targets
  • Transporters:Transporter channels and pores
  • Disease related genes
Cellular Component
GO:0005886 plasma membrane
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

9 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneLOCATENoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
transmembranetransmembrane_predictedPhobiusNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
LAP3PTRHD1P28838Q6GMV30:0hu.MAP
LAP3PTRHD1ZCCHC17P28838Q6GMV3Q9NP640:0:0hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationWestern blotting139195200
Sequence, Structure & Domains

Sequences

Length
417
Mass
45,211
Sequence
MSSKYPRSVRRCLPLWALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAIGLGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPSGKVVITLFSIRLATMSALSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAYFGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISKTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Long; IsoId=Q02161-1; Sequence=Displayed; Name=2; Synonyms=Short 1; IsoId=Q02161-2; Sequence=VSP_005706; Name=3; Synonyms=Short 2; IsoId=Q02161-3; Sequence=VSP_005707, VSP_005708; Name=4; IsoId=Q02161-4; Sequence=VSP_047797; Name=5; IsoId=Q02161-5; Sequence=VSP_047796; Name=6; IsoId=Q02161-6; Sequence=VSP_047795, VSP_047798
Alternative Sequence
314..409; Missing (in isoform 2); 314..378; GCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIAL -> DWLPGPPQHWGTQLGHRDSSHVWSPDSFLIWLLDFKQKHPRKTRPVQKQDNFLSLLPAFVREKRS (in isoform 6); 316; C -> S (in isoform 3); 317..417; Missing (in isoform 3); 358..417; MIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF -> IFLIWLLDFKQKHPRKTRPVQKQDNFLSLLPAFVREKRS (in isoform 5); 359..417; IGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF -> SLGWNLAVKMAEAGDEELMRLDVSQRNHGGAAVPTGSWMPSTETTIAPNYRDHISVVSSFGCWILSKSIQEKQGLFKNKTTSSHCCLHLYVRNAHDSKVSNVRAGTGVRENGVESFLCHSLRRISPFIMHCRIQQ (in isoform 4); 379..417; Missing (in isoform 6)

3D Structural Models

Domain & Motif Annotations

Protein Families
  • Ammonium transporter (TC 2.A.49) family
  • Rh subfamily
Sequence Similarities
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Clinical Relevance
Related Diseases
Anemia
Biomarker
Phase 2/3
Drugs
ROLEDUMABROZROLIMUPABMOROLIMUMABATOROLIMUMAB
Antibody
HPA060951HPA077385