Protein detail

TNR17

Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)

Protein symbol TNR17	UniProt ID Q02223	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)

Protein Function

Predicted intracellular proteins
CD markers
Cancer-related genes
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

55..77; Helical; Signal-anchor for type III membrane protein

Transmembrane Count

Ensembl

ENSG00000048462

Entrez Gene Symbol

TNFRSF17

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificretinaCell SpecificMelanocytesSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway

Protein Function

Predicted intracellular proteins
CD markers
Cancer-related genes
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

60 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Kirouac2010	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TNF13	O75888	TNR17	Q02223	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HPRD:10973284 ICELLNET:11239407 Cellinker:14764606 connectomeDB2020:10973284LRdb:11CellTalkDB:14764606 Cellinker:10973284 HPMR:14764606 connectomeDB2020:14764606 LRdb:14764606 SIGNOR:10973284

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
TNFRSF17	Q02223	2	PDB	PDB:4zfoPDB:6j7wPDB:8hxqPDB:8hxr
OPA3 OTULINL TARBP1 TNFRSF17	Q02223 Q13395 Q9H6K4 Q9NUU6	0:0:0:0	hu.MAP2
OTULINL TARBP1 TNFRSF17	Q02223 Q13395 Q9NUU6	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	1	39195200

Sequence, Structure & Domains

Sequences

Length

184

Mass

20,165

Sequence

MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02223-1; Sequence=Displayed; Name=2; Synonyms=TV4; IsoId=Q02223-2; Sequence=VSP_047678

Alternative Sequence

44..93; SVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTG -> R (in isoform 2)

3D Structural Models

Turn

16..19; 38..40; 42..44

Helix

24..27; 35..37

Beta Strand

12..15; 20..23; 30..32

3D Structure

NMR spectroscopy (1); X-ray crystallography (9)

Domain & Motif Annotations

Repeat

7..41; TNFR-Cys

Clinical Relevance