Protein detail
TNR17
Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Entry name TNR17 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Cancer-related genes
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
55..77; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificretinaCell SpecificMelanocytesSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Cancer-related genes
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
KEGG (2)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationImmune mediation
Relations & Evidence65
Ligand-Receptor Signaling (60)
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane_predicted | transmembrane | OmniPath | Yes | ||||
| transmembrane | transmembrane | CellPhoneDB | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | LOCATE | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | Cellinker | Yes |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TNF13 | O75888 | TNR17 | Q02223 | Yes | Yes | iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | HPRD:10973284ICELLNET:11239407Cellinker:14764606connectomeDB2020:10973284LRdb:11CellTalkDB:14764606Cellinker:10973284HPMR:14764606connectomeDB2020:14764606LRdb:14764606SIGNOR:10973284 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 39195200 |
Sequence, Structure & Domains
Sequences
Length
184
Mass
20,165
Sequence
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02223-1; Sequence=Displayed; Name=2; Synonyms=TV4; IsoId=Q02223-2; Sequence=VSP_047678
Alternative Sequence
44..93; SVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTG -> R (in isoform 2)
3D Structural Models
Turn
16..19; 38..40; 42..44
Helix
24..27; 35..37
Beta Strand
12..15; 20..23; 30..32
3D Structure
NMR spectroscopy (1); X-ray crystallography (9)
Domain & Motif Annotations
Repeat
7..41; TNFR-Cys
Clinical Relevance
Related Diseases (8)
Biomarker
Clinical trial; Phase 1/2; Approved; Phase 1
Drugs (18)
ANTI-BCMA CAR T CELLS PREPARATIONLINOLEIC ACIDELRANATAMABIDECABTAGENE VICLEUCELAUTOLOGOUS ANTI-BCMA-CAR-4-1BB-CD3ZETA-EXPRESSING T-CELLS C-CAR088CILTACABTAGENE AUTOLEUCELAUTOLOGOUS ANTI-BCMA-CAR-MRNA-TRANSFECTED CD8+ T-LYMPHOCYTESAUTOLOGOUS ANTI-BCMA-CAR-TCRZ/4-1BB-EXPRESSING T-LYMPHOCYTES CART-BCMAPACANALOTAMABAUTOLOGOUS ANTI-BCMA-CAR-4-1BB-CD3ZETA-EXPRESSING MEMORY T-LYMPHOCYTES BB21217ORVACABTAGENE AUTOLEUCELBELANTAMAB MAFODOTIN-BLMFP-BCMA-101TECLISTAMAB-CQYVBI6015KITE-585AUTOLOGOUS BCMA/TACI-TARGETED CAR T CELLS AUTO2AUTOLOGOUS ANTI-BCMA-CAR-EXPRESSING CD4+/CD8+ T-LYMPHOCYTES FCARH143
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 33893753 | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy. | No related sentences available |