Protein detail

TIE2

Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)

Entry name
TIE2
UniProt ID
Q02763
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Protein Class (10)
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins
Protein Function (11)
  • ENZYME proteins:Transferases
  • Human disease related genes:Congenital malformations:Congenital malformations of eye
  • CD markers
  • RAS pathway related proteins
  • Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted secreted proteins
  • Kinases:Tyr protein kinases
  • Disease related genes
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Transmembrane
749..769; Helical
Transmembrane Count
1
Ensembl
ENSG00000120156
Entrez Gene Symbol
TEK
Gene Synonym (5)
CD202bTIE-2TIE2VMCMVMCM1
Gene Description
TEK receptor tyrosine kinase
Chromosome
9
Position
27109141-27230174
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway7
Protein Function (11)
  • ENZYME proteins:Transferases
  • Human disease related genes:Congenital malformations:Congenital malformations of eye
  • CD markers
  • RAS pathway related proteins
  • Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted secreted proteins
  • Kinases:Tyr protein kinases
  • Disease related genes
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Cellular Component (15)
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Molecular Function (7)
Biological Process (3)
KEGG (6)
Reactome (5)
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence105

Enzyme-Mediated Modification (9)

9 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
TEKTIE1P35590Y1,102phosphorylationLi2012
TEKTIE1P35590Y1,113phosphorylationLi2012
TEKTIE1P35590Y1,108phosphorylationLi2012
TEKTM7SF2O76062Y992phosphorylationREACH_ProtMapperProtMapperProtMapper:19451274
TEKANGPT1Q15389Y1,102phosphorylationSparser_ProtMapperProtMapperProtMapper:21858121
TEKMAT1AQ00266Y1,102phosphorylationSparser_ProtMapperProtMapperProtMapper:23036162
TEKEGFRP00533Y1,048phosphorylationKEAKEA:17570479
TEKTECP42680Y1,102phosphorylationKEAKEA:12082108KEA:9632797KEA:10521483
TEKTECP42680Y897phosphorylationKEAKEA:11513602KEA:11080633

Ligand-Receptor Signaling (65)

65 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorLRdbNoYesYesYesNo
receptorreceptorSignaLink_functionNoYesYesYesNo
receptor_tyrosine_kinases_rtkreceptorHPMRNoYesYesYesNo
vegf_pdgfreceptorHPMRNoYesYesYesNo
kinasereceptorSurfaceomeNoYesYesYesNo
growth_factorreceptorICELLNETNoYesYesYesNo
receptorreceptorOmniPathNoYesYesYesNo
extracellularextracellularHPMRNoNoYesYesNo
extracellularextracellularOmniPathNoNoYesYesNo
intracellularintracellularLOCATENoNoYesYesNo
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Regulatory Interaction Network (15)

15 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
TIE2Q02763TIE1P35590YesYesNoHPRDPhosphoPointSIGNORSIGNOR:15851516HPRD:10995770
TIE2Q02763P85AP27986YesYesNoHPRDWangPhosphoPointSIGNORHPRD:10521483SIGNOR:14665640
PTPRBP23467TIE2Q02763YesNoYesSIGNORDEPODHPRDHINTInnateDBSPIKE_LCHPRD:10557082DEPOD:19116766SPIKE_LC:19167335InnateDB:12237455DEPOD:19451274DEPOD:10557082HINT:12237455SIGNOR:34417472
TIE2Q02763COMPLEX:P27986_P42336YesYesNoSIGNORSIGNOR:14665640
TIE2Q02763SHC1P29353YesYesNoPhosphoPointSIGNORHPRDInnateDBWangSIGNOR:14665640HPRD:14665640InnateDB:14665640
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Protein Complex Composition (15)

15 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
FAM222ANLKTEKT2Q5U5X8Q9UBE8Q9UIF30:0:0hu.MAP2
ALS2NEK1STXBP6TEKT4URM1Q8NFX7Q8WW24Q96PY6Q96Q42Q9BTM90:0:0:0:0hu.MAP2
ACOT11PTERTEKT2Q8WXI4Q96BW5Q9UIF30:0:0hu.MAP
ACOT11TEKT2Q8WXI4Q9UIF30:0hu.MAP
NLKTEKT2Q9UBE8Q9UIF30:0hu.MAP2
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry124700864
Sequence, Structure & Domains13

Sequences

Length
1,124
Mass
125,830
Sequence
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q02763-1; Sequence=Displayed; Name=2; IsoId=Q02763-2; Sequence=VSP_042138; Name=3; IsoId=Q02763-3; Sequence=VSP_042137, VSP_042138, VSP_042139
Alternative Sequence
18..121; Missing (in isoform 3); 300..342; Missing (in isoform 2 and isoform 3); 788; Missing (in isoform 3)

3D Structural Models

Turn
61..63; 235..237; 271..276; 282..285; 325..327; 1038..1041
Helix
167..169; 183..185; 198..200; 296..298; 380..382; 416..418; 821..823; 864..866; 872..879; 910..916; 919..922; 924..929; 938..957; 967..969; 974..976; 985..987; 1000..1004; 1007..1012; 1017..1032; 1044..1050; 1051..1053; 1065..1074; 1079..1081; 1085..1097; 1118..1120
Beta Strand
26..29; 33..35; 40..46; 56..59; 64..66; 74..76; 80..88; 98..106; 109..119; 123..125; 127..133; 139..145; 153..157; 160..165; 172..178; 187..193; 202..208; 215..217; 246..248; 259..261; 279..281; 286..288; 322..324; 328..330; 361..366; 369..373; 383..386; 396..400; 405..408; 411..414; 420..428; 431..439; 446..449; 452..456; 461..464; 469..472; 476..485; 493..504; 512..521; 534..537; 550..555; 558..562; 569..572; 575..585; 588..594; 598..602; 610..621; 629..632; 643..648; 655..660; 663..665; 669..677; 683..689; 696..699; 707..715; 727..730; 816..818; 824..833; 836..845; 848..857; 888..894; 897..903; 932..936; 970..972; 978..980; 1098..1100
3D Structure
X-ray crystallography (16)

Domain & Motif Annotations

Domain (CC)
The soluble extracellular domain is functionally active in angiopoietin binding and can modulate the activity of the membrane-bound form by competing for angiopoietins.
Domain (FT)
44..123; Ig-like C2-type 1; 210..252; EGF-like 1; 254..299; EGF-like 2; 301..341; EGF-like 3; 350..440; Ig-like C2-type 2; 447..541; Fibronectin type-III 1; 545..636; Fibronectin type-III 2; 641..735; Fibronectin type-III 3; 824..1096; Protein kinase
Protein Families (3)
  • Protein kinase superfamily
  • Tyr protein kinase family
  • Tie subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Clinical Relevance9
Disease Involvement (4)
Cancer-related genesDisease variantFDA approved drug targetsGlaucoma
Related Diseases (10)
Breast cancerChronic arterial occlusive diseaseIschemiaMature B-cell lymphomaMyelodysplastic syndromeMyeloproliferative neoplasmRetinopathyRheumatoid arthritisSepsisSolid tumour/cancer
Biomarker
Phase 1; Phase 2; Investigative; Discontinued in Phase 1; Phase 1/2
Drug Targets
FDA approved drug targets
Drugs (16)
FORETINIBREBASTINIBGLESATINIBREGORAFENIBRAZUPROTAFIBCETIRIZINE HYDROCHLORIDEALTIRATINIBCE-245677LINIFANIBCEP-11981GW559768XPEXMETINIBVANDETANIBCABOZANTINIB S-MALATELOPERAMIDEAMPICILLIN (ANHYDROUS)
Antibody (2)
CAB010359HPA073265
Interaction Protein (2)
ENSG00000091879ENSG00000154188
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications1
PMIDTitleAbstract
38008423Hypoxia-induced endothelial cell-derived exosome stimulates vascular smooth muscle cell proliferation and migration.In summary, hypoxia affected the secretion of extracellular vesicles by endothelial cells, which can be internalized by VSMCs and accelerate the abnormal proliferation and migration of VSMCs by delivering TGFBR1.