Protein detail
TIE2
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Entry name TIE2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins
Protein Function
- ENZYME proteins:Transferases
- Human disease related genes:Congenital malformations:Congenital malformations of eye
- CD markers
- RAS pathway related proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
749..769; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD202bTIE-2TIE2VMCMVMCM1
Gene Description
TEK receptor tyrosine kinase
Chromosome
9
Position
27109141-27230174
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Human disease related genes:Congenital malformations:Congenital malformations of eye
- CD markers
- RAS pathway related proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0001725 stress fiber
- GO:0005576 extracellular region
- GO:0005737 cytoplasm
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005911 cell-cell junction
- GO:0005925 focal adhesion
- GO:0009925 basal plasma membrane
- GO:0009986 cell surface
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0034451 centriolar satellite
- GO:0043235 receptor complex
- GO:0045121 membrane raft
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
9 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TEK | TIE1 | P35590 | Y | 1,102 | phosphorylation | Li2012 | |
| TEK | TIE1 | P35590 | Y | 1,113 | phosphorylation | Li2012 | |
| TEK | TIE1 | P35590 | Y | 1,108 | phosphorylation | Li2012 | |
| TEK | TM7SF2 | O76062 | Y | 992 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:19451274 |
| TEK | ANGPT1 | Q15389 | Y | 1,102 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:21858121 |
| TEK | MAT1A | Q00266 | Y | 1,102 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:23036162 |
| TEK | EGFR | P00533 | Y | 1,048 | phosphorylation | KEA | KEA:17570479 |
| TEK | TEC | P42680 | Y | 1,102 | phosphorylation | KEA | KEA:12082108KEA:9632797KEA:10521483 |
| TEK | TEC | P42680 | Y | 897 | phosphorylation | KEA | KEA:11513602KEA:11080633 |
Ligand-Receptor Signaling
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | iTALK | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| tyrosine_kinase | receptor | HGNC | No | Yes | Yes | Yes | No |
| receptor | receptor | HGNC | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
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Regulatory Interaction Network
15 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TIE2 | Q02763 | TIE1 | P35590 | Yes | Yes | No | HPRDPhosphoPointSIGNOR | SIGNOR:15851516HPRD:10995770 |
| TIE2 | Q02763 | P85A | P27986 | Yes | Yes | No | HPRDWangPhosphoPointSIGNOR | HPRD:10521483SIGNOR:14665640 |
| PTPRB | P23467 | TIE2 | Q02763 | Yes | No | Yes | SIGNORDEPODHPRDHINTInnateDBSPIKE_LC | HPRD:10557082DEPOD:19116766SPIKE_LC:19167335InnateDB:12237455DEPOD:19451274DEPOD:10557082HINT:12237455SIGNOR:34417472 |
| TIE2 | Q02763 | COMPLEX:P27986_P42336 | Yes | Yes | No | SIGNOR | SIGNOR:14665640 | |
| TIE2 | Q02763 | SHC1 | P29353 | Yes | Yes | No | PhosphoPointSIGNORHPRDInnateDBWang | SIGNOR:14665640HPRD:14665640InnateDB:14665640 |
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Protein Complex Composition
15 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FAM222ANLKTEKT2 | Q5U5X8Q9UBE8Q9UIF3 | 0:0:0 | hu.MAP2 | |||
| ALS2NEK1STXBP6TEKT4URM1 | Q8NFX7Q8WW24Q96PY6Q96Q42Q9BTM9 | 0:0:0:0:0 | hu.MAP2 | |||
| ACOT11PTERTEKT2 | Q8WXI4Q96BW5Q9UIF3 | 0:0:0 | hu.MAP | |||
| ACOT11TEKT2 | Q8WXI4Q9UIF3 | 0:0 | hu.MAP | |||
| NLKTEKT2 | Q9UBE8Q9UIF3 | 0:0 | hu.MAP2 |
Page 2 of 2Previous
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 24700864 |
Sequence, Structure & Domains
Sequences
Length
1,124
Mass
125,830
Sequence
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q02763-1; Sequence=Displayed; Name=2; IsoId=Q02763-2; Sequence=VSP_042138; Name=3; IsoId=Q02763-3; Sequence=VSP_042137, VSP_042138, VSP_042139
Alternative Sequence
18..121; Missing (in isoform 3); 300..342; Missing (in isoform 2 and isoform 3); 788; Missing (in isoform 3)
3D Structural Models
Turn
61..63; 235..237; 271..276; 282..285; 325..327; 1038..1041
Helix
167..169; 183..185; 198..200; 296..298; 380..382; 416..418; 821..823; 864..866; 872..879; 910..916; 919..922; 924..929; 938..957; 967..969; 974..976; 985..987; 1000..1004; 1007..1012; 1017..1032; 1044..1050; 1051..1053; 1065..1074; 1079..1081; 1085..1097; 1118..1120
Beta Strand
26..29; 33..35; 40..46; 56..59; 64..66; 74..76; 80..88; 98..106; 109..119; 123..125; 127..133; 139..145; 153..157; 160..165; 172..178; 187..193; 202..208; 215..217; 246..248; 259..261; 279..281; 286..288; 322..324; 328..330; 361..366; 369..373; 383..386; 396..400; 405..408; 411..414; 420..428; 431..439; 446..449; 452..456; 461..464; 469..472; 476..485; 493..504; 512..521; 534..537; 550..555; 558..562; 569..572; 575..585; 588..594; 598..602; 610..621; 629..632; 643..648; 655..660; 663..665; 669..677; 683..689; 696..699; 707..715; 727..730; 816..818; 824..833; 836..845; 848..857; 888..894; 897..903; 932..936; 970..972; 978..980; 1098..1100
3D Structure
X-ray crystallography (16)
Domain & Motif Annotations
Domain (CC)
The soluble extracellular domain is functionally active in angiopoietin binding and can modulate the activity of the membrane-bound form by competing for angiopoietins.
Domain (FT)
44..123; Ig-like C2-type 1; 210..252; EGF-like 1; 254..299; EGF-like 2; 301..341; EGF-like 3; 350..440; Ig-like C2-type 2; 447..541; Fibronectin type-III 1; 545..636; Fibronectin type-III 2; 641..735; Fibronectin type-III 3; 824..1096; Protein kinase
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Tie subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsGlaucoma
Related Diseases
Biomarker
Phase 1; Phase 2; Investigative; Discontinued in Phase 1; Phase 1/2
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000091879ENSG00000154188
Interaction Count
2
Interaction Dataset
intact_biogrid