Protein detail
TGBR3
Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
Entry name TGBR3 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
Transmembrane
788..809; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
betaglycanBGCAN
Gene Description
Transforming growth factor beta receptor 3
Chromosome
1
Position
91680343-91906335
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue Specificchoroid plexusCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cell
Function & Pathway7
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
Cellular Component (10)
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016323 basolateral plasma membrane
- GO:0034673 inhibin-betaglycan-ActRII complex
- GO:0043235 receptor complex
- GO:0070062 extracellular exosome
Molecular Function (15)
- GO:0004888 transmembrane signaling receptor activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005114 type II transforming growth factor beta receptor binding
- GO:0005160 transforming growth factor beta receptor binding
- GO:0005515 protein binding
- GO:0005539 glycosaminoglycan binding
- GO:0008201 heparin binding
- GO:0015026 coreceptor activity
- GO:0017134 fibroblast growth factor binding
- GO:0030165 PDZ domain binding
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Biological Process (3)
Reactome (15)
- R-hsa-190370 fgfr1b ligand binding and activation
- R-hsa-190373 fgfr1c ligand binding and activation
- R-hsa-190242 fgfr1 ligand binding and activation
- R-hsa-1502540 signaling by activin
- R-hsa-201451 signaling by bmp
- R-hsa-190236 signaling by fgfr
- R-hsa-5654736 signaling by fgfr1
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9839373 signaling by tgfbr3
- R-hsa-9006936 signaling by tgfb family members
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Canonical Pathways (2)
- M87 Pid lkb1 pathway
- M17 Pid notch pathway
Mediation Categories (3)
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence70
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TGFBR3 | TGFBR1 | P36897 | S | 831 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling (65)
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TGFB2 | P61812 | TGBR3 | Q03167 | Yes | Yes | No | iTALKSIGNORUniProt_LRdbDIPHPMR_talklrHPMRHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | DIP:10519421SPIKE_LC:11278442SPIKE:11278442DIP:9312157HPRD:11157754LRdb:11HPMR:12809600connectomeDB2020:11157754DIP:8041735LRdb:12809600NetPath:11278442CellTalkDB:12809600Cellinker:12809600SIGNOR:10746731connectomeDB2020:12809600Cellinker:11157754 |
| INHA | P05111 | TGBR3 | Q03167 | Yes | Yes | Yes | Fantom5_LRdbCellTalkDBHPMR_LRdbHPRD_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HPRDHPRD_talklrCellinkerWangLRdbSTRING_talklrHPMR_talklr | connectomeDB2020:12493742Cellinker:12493742LRdb:11LRdb:12493742connectomeDB2020:10746731HPRD:10746731CellTalkDB:12493742SIGNOR:10746731Cellinker:10746731 |
| TGFR1 | P36897 | TGBR3 | Q03167 | Yes | No | Yes | NetPathiPTMnetPhosphoPointProtMapperWangPhosphoSitePhosphoSite_ProtMapper | NetPath:11323414PhosphoSite:22427868 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains11
Sequences
Length
851
Mass
93,499
Sequence
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q03167-1; Sequence=Displayed; Name=2; IsoId=Q03167-2; Sequence=VSP_040018
Alternative Sequence
359; Missing (in isoform 2)
3D Structural Models
Helix
56..59; 140..143; 157..168
Beta Strand
49..51; 60..70; 82..89; 94..96; 100..105; 111..116; 125..129; 134..138; 146..150; 172..178; 181..187
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
817..834; Polar residues; 836..851; Low complexity
Domain (FT)
455..730; ZP
Region
737..751; Interaction with TGF-beta ligand; 816..851; Disordered
Clinical Relevance3
Disease Involvement
Cancer-related genes
Drugs (9)
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 35007697 | Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer. | In conclusion, exosomes derived from TIE2-high cervical cancer cells induce TEMs by directly transporting TIE2 to promote tumor angiogenesis. In vitro and in vivo experiments verified that exosomes derived from TIE2-high cervical cancer cells transferred TIE2 protein directly to macrophages, thereby inducing TEMs. |