Protein detail

UPAR

Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)

Protein symbol UPAR	UniProt ID Q03405	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification Cancer-related genesCD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)

Protein Class

Cancer-related genesCD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Ensembl

ENSG00000011422

Entrez Gene Symbol

PLAUR

Gene Synonym

CD87UPARURKR

Gene Description

Plasminogen activator, urokinase receptor

Chromosome

Position

43646095-43670547

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificneutrophil

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PLAUR	MMP12	P39900	T	108	cleavage	HPRD	HPRD:12195704

Ligand-Receptor Signaling

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	Yes
receptor	receptor	GO_Intercell	No	Yes	Yes	Yes	Yes
receptor	receptor	HPMR	No	Yes	Yes	Yes	Yes
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	Yes
receptor	receptor	CellChatDB	No	Yes	Yes	Yes	Yes
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	Yes
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	Yes
receptor	receptor	Kirouac2010	No	Yes	Yes	Yes	Yes
receptor	receptor	LRdb	No	Yes	Yes	Yes	Yes
receptor	receptor	Baccin2019	No	Yes	Yes	Yes	Yes

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UROK	P00749	UPAR	Q03405	Yes	Yes	No	iTALKKirouac2010ICELLNETSIGNORHINTDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	LRdb:3023326 connectomeDB2020:11501527 HPRD:3023326 Baccin2019:11501527 DIP:18376415 HPMR:16456079 connectomeDB2020:3031025 CellTalkDB:16456079 HINT:11501527 Baccin2019:3031025 SIGNOR:16456079 Baccin2019:16456079 HINT:16979660 LRdb:11501527 BioGRID:16879932 HINT:16456079 LRdb:16456079 connectomeDB2020:3023326 HPRD:3031025 BioGRID:11501527 connectomeDB2020:16456079 HINT:24457100 HINT:16879932 ICELLNET:11501527 LRdb:3031025 BioGRID:19017363 HINT:22285761 Cellinker:3031025 HINT:33961781 HPRD:11501527 HINT:24465541 Baccin2019:3023326 Cellinker:16456079 Cellinker:3023326 HINT:18376415 Cellinker:11501527 SPIKE_LC:16189514
UPAR	Q03405	K2C1	P04264	Yes	Yes	No	SIGNOR	SIGNOR:14691569
UPAR	Q03405	ITB3	P05106	Yes	Yes	No	WangSIGNOR	SIGNOR:27383564

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PLAUR-PLAU complex	PLAU PLAUR	P00749 Q03405	4:4	CORUMComplexPortalPDB	intact:EBI-11890834CORUM:7112PDB:3u73PDB:2i9bPDB:2fd6	1689240 20133942 22285761 16456079 10092105 25671694 14755292 3920216 16979660
uPA-uPAR-vitronectin complex	PLAU PLAUR VTN	P00749 P04004 Q03405	1:1:1	ComplexPortalPDB	PDB:3bt2PDB:3u73PDB:2i9bintact:EBI-11892130PDB:4k24PDB:3bt1	24465541 14755292 18376415 10722842
	PLAUR	Q03405	8	PDB	PDB:7v63PDB:7e17PDB:1ywh

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	28914500

Sequence, Structure & Domains

Sequences

Length

335

Mass

36,978

Sequence

MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=uPAR1, GPI-anchored; IsoId=Q03405-1; Sequence=Displayed; Name=2; Synonyms=uPAR2, Secreted; IsoId=Q03405-2; Sequence=VSP_006715; Name=3; IsoId=Q03405-3; Sequence=VSP_046345, VSP_046346

Alternative Sequence

158..202; Missing (in isoform 3); 203; I -> V (in isoform 3); 253..335; PKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT -> RSLWGSWLPCKSTTALRPPCCEEAQATHV (in isoform 2)

3D Structural Models

Turn

96..99; 122..130; 196..199; 223..225; 229..231; 252..255; 291..294

Helix

206..208; 266..268; 275..278; 296..298

Beta Strand

24..28; 34..38; 45..54; 60..68; 75..81; 84..93; 110..114; 116..121; 133..136; 138..141; 143..150; 155..158; 164..171; 176..183; 186..193; 211..222; 226..228; 233..238; 243..251; 256..264; 270..273; 284..288

3D Structure

X-ray crystallography (11)

Domain & Motif Annotations

Domain (FT)

23..114; UPAR/Ly6 1; 115..213; UPAR/Ly6 2; 214..305; UPAR/Ly6 3

Clinical Relevance

Disease Involvement

Cancer-related genesFDA approved drug targets

Related Diseases

Acquired hypomelanotic disorder Atopic eczema Myeloproliferative neoplasm Pancreatic cancer Thrombocytosis

Biomarker

Phase 1/2; Approved; Phase 3

Drug Targets

FDA approved drug targets

Drugs

RECOMBINANT INTERFERON GAMMA DIPHTHERIA TOXIN UROKINASE LENOGRASTIM PHORBOL 12-MYRISTATE 13-ACETATE ADENOVIRUS VECTOR RUXOLITINIB RECOMBINANT HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN-2

Antibody

HPA050843 CAB073533

Interaction Protein

ENSG00000122861

Interaction Count

Interaction Dataset

intact_biogrid