Protein detail

UPAR

Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)

Entry name UPAR	UniProt ID Q03405	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Cancer-related genesCD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)

Protein Class (5)

Cancer-related genesCD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (4)

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Ensembl

ENSG00000011422

Entrez Gene Symbol

PLAUR

Gene Synonym (3)

CD87UPARURKR

Gene Description

Plasminogen activator, urokinase receptor

Chromosome

Position

43646095-43670547

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificneutrophil

Function & Pathway7

Protein Function (4)

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component (13)

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Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (7)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence59

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PLAUR	MMP12	P39900	T	108	cleavage	HPRD	HPRD:12195704

Ligand-Receptor Signaling (51)

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	Yes	Yes
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	Yes	Yes	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	Yes	Yes	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	CSPA	No	No	Yes	Yes	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	OmniPath	No	No	Yes	Yes	Yes
secreted	secreted	UniProt_keyword	No	No	Yes	Yes	Yes
secreted	secreted	OmniPath	No	No	Yes	Yes	Yes
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	Yes
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	Yes	Yes

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UROK	P00749	UPAR	Q03405	Yes	Yes	No	iTALKKirouac2010ICELLNETSIGNORHINTDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	LRdb:3023326 connectomeDB2020:11501527 HPRD:3023326 Baccin2019:11501527 DIP:18376415 HPMR:16456079 connectomeDB2020:3031025 CellTalkDB:16456079 HINT:11501527 Baccin2019:3031025 SIGNOR:16456079 Baccin2019:16456079 HINT:16979660 LRdb:11501527 BioGRID:16879932 HINT:16456079 LRdb:16456079 connectomeDB2020:3023326 HPRD:3031025 BioGRID:11501527 connectomeDB2020:16456079 HINT:24457100 HINT:16879932 ICELLNET:11501527 LRdb:3031025 BioGRID:19017363 HINT:22285761 Cellinker:3031025 HINT:33961781 HPRD:11501527 HINT:24465541 Baccin2019:3023326 Cellinker:16456079 Cellinker:3023326 HINT:18376415 Cellinker:11501527 SPIKE_LC:16189514
UPAR	Q03405	K2C1	P04264	Yes	Yes	No	SIGNOR	SIGNOR:14691569
UPAR	Q03405	ITB3	P05106	Yes	Yes	No	WangSIGNOR	SIGNOR:27383564

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PLAUR-PLAU complex	PLAU PLAUR	P00749 Q03405	4:4	CORUMComplexPortalPDB	intact:EBI-11890834CORUM:7112PDB:3u73PDB:2i9bPDB:2fd6	1689240 20133942 22285761 16456079 10092105 25671694 14755292 3920216 16979660
uPA-uPAR-vitronectin complex	PLAU PLAUR VTN	P00749 P04004 Q03405	1:1:1	ComplexPortalPDB	PDB:3bt2PDB:3u73PDB:2i9bintact:EBI-11892130PDB:4k24PDB:3bt1	24465541 14755292 18376415 10722842
	PLAUR	Q03405	8	PDB	PDB:7v63PDB:7e17PDB:1ywh

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	28914500

Sequence, Structure & Domains10

Sequences

Length

335

Mass

36,978

Sequence

MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=uPAR1, GPI-anchored; IsoId=Q03405-1; Sequence=Displayed; Name=2; Synonyms=uPAR2, Secreted; IsoId=Q03405-2; Sequence=VSP_006715; Name=3; IsoId=Q03405-3; Sequence=VSP_046345, VSP_046346

Alternative Sequence

158..202; Missing (in isoform 3); 203; I -> V (in isoform 3); 253..335; PKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT -> RSLWGSWLPCKSTTALRPPCCEEAQATHV (in isoform 2)

3D Structural Models

Turn

96..99; 122..130; 196..199; 223..225; 229..231; 252..255; 291..294

Helix

206..208; 266..268; 275..278; 296..298

Beta Strand

24..28; 34..38; 45..54; 60..68; 75..81; 84..93; 110..114; 116..121; 133..136; 138..141; 143..150; 155..158; 164..171; 176..183; 186..193; 211..222; 226..228; 233..238; 243..251; 256..264; 270..273; 284..288

3D Structure

X-ray crystallography (11)

Domain & Motif Annotations

Domain (FT)

23..114; UPAR/Ly6 1; 115..213; UPAR/Ly6 2; 214..305; UPAR/Ly6 3

Clinical Relevance9

Disease Involvement (2)

Cancer-related genesFDA approved drug targets

Related Diseases (5)

Acquired hypomelanotic disorder Atopic eczema Myeloproliferative neoplasm Pancreatic cancer Thrombocytosis

Biomarker

Phase 1/2; Approved; Phase 3

Drug Targets

FDA approved drug targets

Drugs (8)

RECOMBINANT INTERFERON GAMMA DIPHTHERIA TOXIN UROKINASE LENOGRASTIM PHORBOL 12-MYRISTATE 13-ACETATE ADENOVIRUS VECTOR RUXOLITINIB RECOMBINANT HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN-2

Antibody (2)

HPA050843 CAB073533

Interaction Protein

ENSG00000122861

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
37670049	Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility.	No abstract available