Protein detail

PTH1R

Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)

Entry name PTH1R	UniProt ID Q03431	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)

Protein Class

Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Human disease related genes:Digestive system diseases:Mouth and dental diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

187..211; Helical; Name=1; 220..241; Helical; Name=2; 283..307; Helical; Name=3; 321..342; Helical; Name=4; 358..382; Helical; Name=5; 407..426; Helical; Name=6; 435..462; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000160801

Entrez Gene Symbol

PTH1R

Gene Synonym

PTHRPTHR1

Gene Description

Parathyroid hormone 1 receptor

Chromosome

Position

46877721-46903799

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Human disease related genes:Digestive system diseases:Mouth and dental diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTH1R	IGF1R	P08069	Y	494	phosphorylation	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:29507819
PTH1R	PTH	P01270	T	387	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29444827

Ligand-Receptor Signaling

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTHR	P12272	PTH1R	Q03431	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDIntActGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	HINT:36482086 Cellinker:9108031 HINT:37148874 HINT:36409914 CellChatDB:29577935 IntAct:19674967 connectomeDB2020:8702701 scConnect:8702701 HPMR:2558877 HINT:37587780 Cellinker:29577935 HINT:9108031 HINT:19674967 LRdb:8702701 LRdb:9108031 connectomeDB2020:9108031 SIGNOR:8683730 HINT:35932760 ICELLNET:15361064 Guide2Pharma:8702701 LRdb:2558877 Cellinker:2558877 HPRD:9108031 connectomeDB2020:2558877 Cellinker:8702701 CellTalkDB:9108031 SPIKE_LC:16189514
PTHY	P01270	PTH1R	Q03431	Yes	Yes	No	iTALKKEGG-MEDICUSICELLNETSIGNORProtMapperHINTHPMR_talklrCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbHPRD_talklrBaccin2019CellinkerREACH_ProtMapperSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	IntAct:19674967 Cellinker:12947048Baccin2019:129470489108031HPRD:9108031 ProtMapper:29444827 CellTalkDB:12947048 LRdb:12947048LRdb:91HINT:36482086 Cellinker:9108031 HINT:35932760 HINT:37148874 ICELLNET:12947048 SIGNOR:18981475 HINT:9108031 HINT:19674967 connectomeDB2020:9108031 connectomeDB2020:12947048
PTH1R	Q03431	LRP6	O75581	Yes	Yes	No	SIGNOR	SIGNOR:23151663
PTH1R	Q03431	GNAS3	O95467	Yes	Yes	No	KEGG-MEDICUSHINTSIGNOR	HINT:37286611 HINT:35932760 SIGNOR:28363951 HINT:37148874
PTH1R	Q03431	ALEX	P84996	Yes	Yes	No	KEGG-MEDICUSHINTSIGNOR	HINT:37286611 HINT:35932760 SIGNOR:28363951 HINT:37148874
PTH1R	Q03431	GNAS2	P63092	Yes	Yes	No	KEGG-MEDICUSHINTSIGNOR	HINT:37286611 HINT:35932760 SIGNOR:28363951 HINT:37148874
PTH1R	Q03431	GNAS1	Q5JWF2	Yes	Yes	No	KEGG-MEDICUSHINTSIGNOR	HINT:37286611 HINT:35932760 SIGNOR:28363951 HINT:37148874
PTH1R	Q03431	GNAQ	P50148	Yes	Yes	No	SIGNOR	SIGNOR:28363951
IGF1R	P08069	PTH1R	Q03431	Yes	No	No	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:29507819 PhosphoSite:29507819

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
PTH PTH1R	P01270 Q03431	2:2	PDB	PDB:3c4m
PTH1R PTHLH	P12272 Q03431	3:3	PDB	PDB:7uzpPDB:7uzoPDB:8d52PDB:3h3gPDB:8d51
PTH1R	Q03431	2	PDB	PDB:3l2j
DNAJC17 PTH1R	Q03431 Q9NVM6	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Ultrafiltration / Tangential Flow Filtration	Mass spectrometry	1	39207047

Sequence, Structure & Domains

Sequences

Length

593

Mass

66,361

Sequence

MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM

3D Structural Models

Turn

158..161; 393..396; 423..426; 460..462

Helix

34..55; 168..171; 178..211; 213..215; 218..245; 274..277; 279..311; 317..346; 357..360; 361..391; 400..417; 419..422; 435..459; 464..478

Beta Strand

112..115; 126..130; 136..138; 143..148; 152..154; 312..314; 350..352; 432..434; 588..592

3D Structure

Electron microscopy (24); NMR spectroscopy (1); X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias

540..554; Low complexity

Motif

474..477; Important for interaction with G proteins

Region

66..102; Disordered; 524..593; Disordered

Protein Families

G-protein coupled receptor 2 family

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family.

Clinical Relevance

Disease Involvement

Disease variantDwarfismFDA approved drug targets

Related Diseases

Hypo-parathyroidism Low bone mass disorder

Biomarker

Phase 1; Approved

Drug Targets

FDA approved drug targets

Drugs

ESTRADIOL VALERATE TERIPARATIDE PARATHYROID HORMONE ABALOPARATIDE TERIPARATIDE ACETATE PTHRP 9-AMINOCAMPTOTHECIN CHEMBL:CHEMBL599896 OSTABOLIN-C PCO-371 RECOMBINANT TRANSFORMING GROWTH FACTOR CHEMBL:CHEMBL586870 DEXAMETHASONE

Antibody

HPA007491 HPA075879

Interaction Protein

ENSG00000087494ENSG00000152266

Interaction Count

Interaction Dataset

intact_biogrid