Protein detail
NOTC2
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Entry name NOTC2 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 16 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Protein Class (6)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
Transmembrane
1678..1698; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Notch receptor 2
Chromosome
1
Position
119911553-120100779
Supporting publications (n)
16
EVMP confidence score
0.60
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells
Function & Pathway7
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
Cellular Component (10)
Molecular Function (7)
Biological Process (3)
KEGG (9)
- hsa01522 Endocrine resistance
- KEGG:hsa04330 Notch signaling pathway
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05207 Chemical carcinogenesis - receptor activation
- KEGG:hsa05224 Breast cancer
Reactome (15)
- R-hsa-5083630 defective lfng causes scdo3
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-2979096 notch2 activation and transmission of signal to the nucleus
- R-hsa-2197563 notch2 intracellular domain regulates transcription
- R-hsa-9013695 notch4 intracellular domain regulates transcription
- R-hsa-350054 notch hlh transcription pathway
- R-hsa-1912422 pre notch expression and processing
- R-hsa-1912420 pre notch processing in golgi
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Mediation Categories (3)
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence101
Enzyme-Mediated Modification (8)
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NOTCH2 | GSK3B | P49841 | S | 2,070 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | KEA:15302935SIGNOR:12794074KEA:12794074HPRD:15302935HPRD:20068231ProtMapper:12794074HPRD:18669648 |
| NOTCH2 | GSK3B | P49841 | S | 2,093 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | SIGNOR:12794074ProtMapper:12794074KEA:12794074HPRD:12794074 |
| NOTCH2 | GSK3B | P49841 | T | 2,068 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | SIGNOR:12794074ProtMapper:12794074KEA:12794074HPRD:12794074 |
| NOTCH2 | GSK3B | P49841 | T | 2,074 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | SIGNOR:12794074KEA:12794074ProtMapper:12794074HPRD:18669648HPRD:12794074 |
| NOTCH2 | GSK3B | P49841 | T | 1,808 | phosphorylation | KEA | KEA:17570479 |
| NOTCH2 | CDK1 | P06493 | T | 1,808 | phosphorylation | KEA | KEA:17570479 |
| NOTCH2 | CDK2 | P24941 | S | 2,070 | phosphorylation | KEA | KEA:17570479 |
| NOTCH2 | MAPK14 | Q16539 | T | 1,808 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (62)
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network (21)
21 records.
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Protein Complex Composition (9)
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MAML1-RBP-Jkappa-Notch2 complex | MAML1NOTCH2RBPJ | Q04721Q06330Q92585 | 1:1:1 | Compleat | Compleat:HC2403 | 11101851 |
| MAML2-RBP-Jkappa-Notch2 complex | MAML2NOTCH2RBPJ | Q04721Q06330Q8IZL2 | 1:1:1 | Compleat | Compleat:HC726 | 12370315 |
| MAML3-RBP-Jkappa-Notch2 complex | MAML3NOTCH2RBPJ | Q04721Q06330Q96JK9 | 1:1:1 | Compleat | Compleat:HC564 | 12370315 |
| ARPC2MED10MED11MED14MED16MED18MED20MED27MED28MED30MED4MED6MED8MED9NOTCH2 | O15144O60244O75586Q04721Q6P2C8Q96G25Q96HR3Q9BTT4Q9BUE0Q9H204Q9H944Q9NPJ6Q9NWA0Q9P086Q9Y2X0 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4124 | ||
| FBXO28NOTCH2PSMB1SPEN | P20618Q04721Q96T58Q9NVF7 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_392 | ||
| NOTCH2 | Q04721 | 2 | PDB | PDB:2oo4 | ||
| MAML1NOTCH2RBPJZNF589 | Q04721Q06330Q86UQ0Q92585 | 0:0:0:0 | hu.MAP | |||
| ANKRD44NOTCH2 | Q04721Q8N8A2 | 0:0 | hu.MAP2 | |||
| ANKRD44NOTCH2PPP6R1 | Q04721Q8N8A2Q9UPN7 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains13
Sequences
Length
2,471
Mass
265,405
Sequence
MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPHNNMQVYA
3D Structural Models
Turn
418..420; 1446..1448; 1453..1458; 1462..1465; 1487..1490
Helix
459..462; 497..500; 1428..1433; 1441..1443; 1449..1452; 1472..1474; 1482..1484; 1491..1494; 1506..1512; 1520..1522; 1525..1532; 1555..1560; 1562..1573; 1632..1635; 1643..1656
Beta Strand
426..428; 432..436; 439..443; 448..450; 470..474; 477..481; 486..488; 508..512; 515..519; 1436..1438; 1477..1479; 1515..1517; 1544..1553; 1575..1579; 1589..1595; 1618..1628; 1663..1670
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1774..1783; Acidic residues; 2098..2107; Basic residues; 2108..2117; Polar residues; 2137..2150; Polar residues; 2159..2168; Polar residues; 2388..2406; Polar residues; 2417..2445; Low complexity
Repeat
1425..1465; LNR 1; 1466..1502; LNR 2; 1503..1544; LNR 3; 1827..1871; ANK 1; 1876..1905; ANK 2; 1909..1939; ANK 3; 1943..1972; ANK 4; 1976..2005; ANK 5; 2009..2038; ANK 6
Domain (FT)
26..63; EGF-like 1; 64..102; EGF-like 2; 105..143; EGF-like 3; 144..180; EGF-like 4; 182..219; EGF-like 5; calcium-binding; 221..258; EGF-like 6; 260..296; EGF-like 7; calcium-binding; 298..336; EGF-like 8; calcium-binding; 338..374; EGF-like 9; calcium-binding; 375..413; EGF-like 10; 415..454; EGF-like 11; calcium-binding; 456..492; EGF-like 12; calcium-binding; 494..530; EGF-like 13; calcium-binding; 532..568; EGF-like 14; calcium-binding; 570..605; EGF-like 15; calcium-binding; 607..643; EGF-like 16; calcium-binding; 645..680; EGF-like 17; calcium-binding; 682..718; EGF-like 18; calcium-binding; 720..755; EGF-like 19; 757..793; EGF-like 20; calcium-binding; 795..831; EGF-like 21; calcium-binding; 833..871; EGF-like 22; 873..909; EGF-like 23; calcium-binding; 911..947; EGF-like 24; calcium-binding; 949..985; EGF-like 25; calcium-binding; 987..1023; EGF-like 26; calcium-binding; 1025..1061; EGF-like 27; calcium-binding; 1063..1099; EGF-like 28; 1101..1147; EGF-like 29; 1149..1185; EGF-like 30; calcium-binding; 1187..1223; EGF-like 31; calcium-binding; 1225..1262; EGF-like 32; calcium-binding; 1264..1302; EGF-like 33; 1304..1343; EGF-like 34; 1374..1412; EGF-like 35
Region
1425..1677; Negative regulatory region (NRR); 1754..1788; Disordered; 2091..2168; Disordered; 2380..2471; Disordered
Protein Families
NOTCH family
Sequence Similarities
Belongs to the NOTCH family.
Clinical Relevance8
Disease Involvement (3)
Cancer-related genesDisease variantOsteoporosis
Related Diseases (2)
Biomarker
Phase 2
Drugs (7)
Antibody
Interaction Protein (2)
ENSG00000149418ENSG00000206560
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications16
| PMID | Title | Abstract |
|---|---|---|
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |
| 39478498 | Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40545963 | Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer. | No abstract available |
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