Protein detail
PTN12
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Entry name PTN12 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 12 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
PTP-PESTPTPG1
Gene Description
Protein tyrosine phosphatase non-receptor type 12
Chromosome
7
Position
77537295-77640069
Supporting publications (n)
12
EVMP confidence score
0.60
Function & Pathway6
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (7)
Molecular Function (5)
Biological Process (3)
Reactome (14)
- R-hsa-9634285 constitutive signaling by overexpressed erbb2
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-8863795 downregulation of erbb2 signaling
- R-hsa-182971 egfr downregulation
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9008059 interleukin 37 signaling
- R-hsa-1250196 shc1 events in erbb2 signaling
- R-hsa-177929 signaling by egfr
- R-hsa-1227986 signaling by erbb2
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Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence49
Enzyme-Mediated Modification (24)
24 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PTPN12 | PRRT2 | Q7Z6L0 | S | 435 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:7520867 |
| PTPN12 | AKT1 | P31749 | S | 39 | phosphorylation | KEA | KEA:17570479 |
| PTPN12 | RPS6KA3 | P51812 | S | 39 | phosphorylation | KEA | KEA:17570479 |
| PTPN12 | RPS6KA3 | P51812 | S | 435 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (18)
18 records.
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [MALDI TOF] | 1 | 40326690 |
Sequence, Structure & Domains14
Sequences
Length
780
Mass
88,106
Sequence
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q05209-1; Sequence=Displayed; Name=2; IsoId=Q05209-2; Sequence=VSP_046274; Name=3; IsoId=Q05209-3; Sequence=VSP_054168
Alternative Sequence
1..130; Missing (in isoform 2); 1..119; Missing (in isoform 3)
3D Structural Models
Turn
43..46; 111..113; 270..272
Helix
3..17; 27..42; 51..54; 56..61; 71..73; 114..123; 207..219; 236..252; 262..269; 280..298
Beta Strand
74..76; 90..94; 102..106; 128..131; 135..137; 155..157; 160..170; 173..182; 185..194; 222..225; 227..230; 232..235
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
502..519; Polar residues; 521..533; Basic and acidic residues; 552..577; Polar residues; 587..601; Polar residues; 602..613; Basic and acidic residues; 622..639; Low complexity; 690..703; Polar residues; 704..725; Basic and acidic residues; 771..780; Basic and acidic residues
Domain (FT)
28..293; Tyrosine-protein phosphatase
Region
345..438; Interaction with TGFB1I1; 502..639; Disordered; 657..725; Disordered; 744..780; Disordered
Protein Families (2)
- Protein-tyrosine phosphatase family
- Non-receptor class 4 subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Clinical Relevance5
Interaction Protein (6)
ENSG00000050820ENSG00000089159ENSG00000111679ENSG00000140368ENSG00000146648ENSG00000160691
Interaction Count
6
Interaction Dataset (2)
intact_biogridintact_biogrid_opencell
Supporting Publications12
| PMID | Title | Abstract |
|---|---|---|
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 33441949 | Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma. | No abstract available |
| 34815502 | The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients. | No abstract available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No abstract available |
| 36736734 | Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No abstract available |
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