Protein detail
CALD1
Caldesmon (CDM)
Protein symbol CALD1 | UniProt ID | EVMP score 0.50 |
Frequency 7 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Caldesmon (CDM)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CDMH-CADh-CDL-CAD
Gene Description
Caldesmon 1
Chromosome
7
Position
134744252-134970729
Frequency
7
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbreastCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M31 Pid beta catenin deg pathway
- M90 Pid wnt canonical pathway
- M83 Pid cdc42 reg pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
58 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CALD1 | MAPK3 | P27361 | S | 789 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10514499phosphoELM:10514499KEA:10514499KEA:1601129 |
| CALD1 | MAPK3 | P27361 | S | 759 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10514499SIGNOR:10514499ProtMapper:11983427SIGNOR:11983427 |
| CALD1 | MAPK3 | P27361 | S | 534 | phosphorylation | PhosphoSiteKEA | KEA:10514499KEA:1601129 |
| CALD1 | MAPK3 | P27361 | S | 724 | phosphorylation | PhosphoNetworks | |
| CALD1 | MAPK3 | P27361 | T | 730 | phosphorylation | PhosphoNetworks | |
| CALD1 | MAPK3 | P27361 | S | 528 | phosphorylation | KEA | KEA:10514499KEA:1601129 |
| CALD1 | MAPK3 | P27361 | S | 554 | phosphorylation | KEA | KEA:10514499KEA:1601129 |
| CALD1 | MAPK3 | P27361 | S | 560 | phosphorylation | KEA | KEA:10514499KEA:1601129 |
| CALD1 | MYLK | Q15746 | S | 744 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:20536391SIGNOR:20536391 |
| CALD1 | PAK3 | O75914 | S | 744 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:20858431ProtMapper:20858431 |
Page 1 of 6Next
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK01 | P28482 | CALD1 | Q05682 | Yes | Yes | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:10514499SIGNOR:10514499 |
| KPCA | P17252 | CALD1 | Q05682 | Yes | No | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapper | ProtMapper:8182108SIGNOR:8182108ProtMapper:16627824 |
| MYLK | Q15746 | CALD1 | Q05682 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:20536391SIGNOR:20536391 |
| KCC2A | Q9UQM7 | CALD1 | Q05682 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:2170388SIGNOR:2170388 |
| MK03 | P27361 | CALD1 | Q05682 | Yes | No | Yes | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11983427ProtMapper:10514499KEA:10514499KEA:1601129PhosphoSite:11983427SIGNOR:10514499phosphoELM:10514499ProtMapper:11983427 |
| PAK3 | O75914 | CALD1 | Q05682 | Yes | No | Yes | iPTMnetSIGNORProtMapperKEAphosphoELM_KEASIGNOR_ProtMapper | KEA:10636898SIGNOR:20858431ProtMapper:20858431 |
| PAK2 | Q13177 | CALD1 | Q05682 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:16800003 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CALD1EID2KERALZTR1NCOA5NUDT12RIT1ZNF517 | O60938Q05682Q6ZMY9Q8N653Q8N6I1Q92963Q9BQG2Q9HCD5 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| CALD1DNAJC8HNRNPA0TMPO | O75937P42166Q05682Q13151 | 0:0:0:0 | hu.MAP2 | |||
| CALD1DNAJC8HNRNPA0TMPO | O75937P42167Q05682Q13151 | 0:0:0:0 | hu.MAP2 | |||
| CALD1FDXACB1THUMPD1 | Q05682Q9BRP7Q9NXG2 | 0:0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
793
Mass
93,231
Sequence
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=H-CAD; IsoId=Q05682-1; Sequence=Displayed; Name=2; Synonyms=WI-38 L-CAD I; IsoId=Q05682-2; Sequence=VSP_004155; Name=3; Synonyms=HELA L-CAD I; IsoId=Q05682-3; Sequence=VSP_004154, VSP_004155; Name=4; Synonyms=WI-38 L-CAD II, 1-CAD; IsoId=Q05682-4; Sequence=VSP_004156; Name=5; Synonyms=HELA L-CAD II; IsoId=Q05682-5; Sequence=VSP_004154, VSP_004156; Name=6; IsoId=Q05682-6; Sequence=VSP_004155, VSP_043292
Alternative Sequence
1..24; MDDFERRRELRRQKREEMRLEAER -> MLGGSGSHGRRSLAALSQ (in isoform 3 and isoform 5); 208..462; Missing (in isoform 4 and isoform 5); 208..436; Missing (in isoform 2, isoform 3 and isoform 6); 660; Missing (in isoform 6)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
47..56; Basic and acidic residues; 60..74; Polar residues; 108..122; Basic and acidic residues; 146..162; Basic and acidic residues; 173..188; Basic and acidic residues; 236..407; Basic and acidic residues; 435..458; Basic and acidic residues; 532..558; Basic and acidic residues; 566..633; Basic and acidic residues; 721..733; Polar residues; 765..784; Basic and acidic residues
Repeat
319..332; 1; 333..346; 2; 347..360; 3
Domain (CC)
The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.
Region
26..207; Myosin and calmodulin-binding; 26..94; Disordered; 108..407; Disordered; 319..375; 3 X 14 AA tandem repeats of E-E-E-K-R-A-A-E-E-R-Q-R-I-K; 434..458; Disordered; 492..640; Disordered; 564..621; Tropomyosin-binding; 653..686; Strong actin-binding; 664..674; Tropomyosin-binding; 687..706; Disordered; 716..722; Calmodulin-binding; 721..740; Disordered; 747..793; Disordered; 768..793; Weak actin-binding
Protein Families
Caldesmon family
Sequence Similarities
Belongs to the caldesmon family.