Protein detail

TYRO3

Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)

Entry name TYRO3	UniProt ID Q06418	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (5)

Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (5)

Predicted intracellular proteins
ENZYME proteins:Transferases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases

Transmembrane

430..450; Helical

Transmembrane Count

Ensembl

ENSG00000092445

Entrez Gene Symbol

TYRO3

Gene Synonym (7)

BrtDtkEtk-2RekRSESkyTif

Gene Description

TYRO3 protein tyrosine kinase

Chromosome

Position

41557675-41583589

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAdrenal medulla cells

Function & Pathway7

Protein Function (5)

Predicted intracellular proteins
ENZYME proteins:Transferases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases

Cellular Component (6)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (4)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence73

Ligand-Receptor Signaling (62)

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
growth_factor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No
tyrosine_kinase	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GRK6	P43250	TYRO3	Q06418	Yes	Yes	No	SignaLink3	SignaLink3:8939948 SignaLink3:23331499
TYRO3	Q06418	P85A	P27986	Yes	Yes	No	HPRDLit-BM-17PhosphoPointSignaLink3	SignaLink3:18988627 HPRD:10627473 SignaLink3:10627473 SignaLink3:23331499 Lit-BM-17:10627473
GAS6	Q14393	TYRO3	Q06418	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTInnateDBHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HINT:8939948 Cellinker:8939948 Guide2Pharma:8939948 HPRD:8939948 Cellinker:27801848 Baccin2019:8939948 Baccin2019:7867073 Cellinker:7867073 connectomeDB2020:8621659 scConnect:8939948 HPRD:8621659 SIGNOR:7867073 CellChatDB:27801848 ICELLNET:25568918 HINT:8621659 connectomeDB2020:8939948 connectomeDB2020:7867073 HPMR:7867073 Cellinker:8621659 LRdb:8939948 InnateDB:8939948 CellTalkDB:7867073 LRdb:7867073 Baccin2019:8621659 BioGRID:8621659 LRdb:8621659
TYRO3	Q06418	CBLB	Q13191	Yes	Yes	No	REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper	ProtMapper:31531847 SIGNOR:31531847
CBLB	Q13191	TYRO3	Q06418	Yes	Yes	No	SIGNOR	SIGNOR:31531847
TYRO3	Q06418	FOXO3	O43524	Yes	No	Yes	SIGNOR	SIGNOR:21291561
TYRO3	Q06418	MLKL	Q8NB16	Yes	Yes	No	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	SIGNOR:31230815 PhosphoSite:31230815

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HDLBP NXT1 PPP1R14C SNX2 TRMT6 TRMT61A TTC4 TYRO3 UPF1 VPS25 VPS26A VPS26B VPS29 VPS35 VPS36 ZNHIT2	O60749 O75436 O95801 Q00341 Q06418 Q4G0F5 Q86VN1 Q8TAE6 Q92900 Q96FX7 Q96QK1 Q9BRG1 Q9UBQ0 Q9UHR6 Q9UJA5 Q9UKK6	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_608
CHRNB3 TYRO3	Q05901 Q06418	0:0	hu.MAPhu.MAP2
TYRO3	Q06418	2	PDB	PDB:1rhf

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingMass spectrometry [LTQ-FT Ultra]Western blotting\|FACSFACSFlow cytometry	8	30909692 29484441 16229685 18381078 19188015 36612172 37549991 39317350

Sequence, Structure & Domains10

Sequences

Length

890

Mass

96,905

Sequence

MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC

3D Structural Models

Helix

109..111

Beta Strand

50..55; 60..68; 74..78; 85..94; 97..106; 113..121; 131..136; 140..143; 148..150; 156..163; 165..167; 170..175; 183..192; 199..207; 210..213; 217..221

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

41..128; Ig-like C2-type 1; 139..220; Ig-like C2-type 2; 227..320; Fibronectin type-III 1; 325..416; Fibronectin type-III 2; 518..790; Protein kinase

Region

815..837; Disordered; 851..871; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
AXL/UFO subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Clinical Relevance8

Disease Involvement

Cancer-related genes

Related Diseases

Solid tumour/cancer

Biomarker

Phase 1

Drugs (19)

TOZASERTIB NULL VANDETANIB CHEMBL:CHEMBL379975 AST-487 ZM447439 JNJ-7706621 SP-600125 MLN-8054 DOVITINIB PD-0166285 SNS-314 DEZAPELISIB DORAMAPIMOD ADAVOSERTIB ILORASERTIB ITACITINIB CHEMBL:CHEMBL1997335 CHEMBL:CHEMBL546797

Antibody

HPA071245

Interaction Protein

ENSG00000177885

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available