Protein detail
NPT2A
Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1)
Entry name NPT2A | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Urinary system diseases:Kidney diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Transmembrane
104..125; Helical; Name=M1; 146..163; Helical; Name=M2; 166..185; Helical; Name=M3; 348..370; Helical; Name=M4; 413..436; Helical; Name=M5; 467..487; Helical; Name=M6; 514..534; Helical; Name=M7; 540..561; Helical; Name=M8
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
NAPI-3NPT2NPTIIaSLC11SLC17A2
Gene Description
Solute carrier family 34 member 1
Chromosome
5
Position
177379235-177398848
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbreastCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor
Function & Pathway
Protein Function
- Human disease related genes:Urinary system diseases:Kidney diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component
- GO:0005654 nucleoplasm
- GO:0005768 endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005903 brush border
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0016607 nuclear speck
- GO:0031526 brush border membrane
- GO:0031982 vesicle
- GO:0048471 perinuclear region of cytoplasm
- GO:0072686 mitotic spindle
Molecular Function
Biological Process
Reactome
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958790 slc mediated transport of inorganic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-427652 sodium coupled phosphate cotransporters
- R-hsa-5683826 surfactant metabolism
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass Spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
639
Mass
68,937
Sequence
MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHSLIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q06495-1; Sequence=Displayed; Name=2; IsoId=Q06495-2; Sequence=VSP_042311
Alternative Sequence
313..639; APTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL -> QNLEGREITHFDLRKKQAMEDSSVPHCP (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
SLC34A transporter family
Sequence Similarities
Belongs to the SLC34A transporter family.