Protein detail

TNR9

Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)

Entry name TNR9	UniProt ID Q07011	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)

Protein Function (4)

Cancer-related genes:Candidate cancer biomarkers
Transporters
CD markers
Predicted intracellular proteins

Transmembrane

187..213; Helical

Transmembrane Count

Ensembl

ENSG00000049249

Entrez Gene Symbol

TNFRSF9

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificblood vesselBrain Regional SpecificmidbrainCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificmidbrain-derived inhibitory

Function & Pathway7

Protein Function (4)

Cancer-related genes:Candidate cancer biomarkers
Transporters
CD markers
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (62)

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
tumor_necrosis_factor	receptor	Almen2009	No	Yes	No	Yes	No
tnf_receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
cytokine	receptor	Baccin2019	No	Yes	No	Yes	No
tnf_ngf	receptor	HPMR	No	Yes	No	Yes	No
tnr9_tnf_ngf	receptor	HPMR	No	Yes	No	Yes	No
tnfngf	receptor	Surfaceome	No	Yes	No	Yes	No
checkpoint	receptor	ICELLNET	No	Yes	No	Yes	No
checkpoint_tnf	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TNFRSF9 TNFSF9	P41273 Q07011	12:12	PDB	PDB:6cu0PDB:6bwvPDB:6a3vPDB:6mgpPDB:6cpr
	TNFRSF9	Q07011	4	PDB	PDB:9f7zPDB:8oz3PDB:8gyePDB:6mi2PDB:6a3wPDB:6mhr

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	38321535

Sequence, Structure & Domains9

Sequences

Length

255

Mass

27,899

Sequence

MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL

3D Structural Models

Turn

39..42

Helix

27..30; 97..99; 139..142

Beta Strand

35..37; 45..47; 55..58; 60..64; 72..76; 80..82; 85..88; 92..96; 101..104; 110..113; 116..119; 128..131; 145..148; 152..154; 157..159

3D Structure

X-ray crystallography (14)

Domain & Motif Annotations

Repeat

24..45; TNFR-Cys 1; 47..86; TNFR-Cys 2; 87..118; TNFR-Cys 3; 119..159; TNFR-Cys 4

Region

161..180; Disordered; 214..255; Interaction with LRR-1

Clinical Relevance1

Drugs (3)

URELUMAB NULL UTOMILUMAB

Supporting Publications4

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
40089067	Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells.	No abstract available