Protein detail
TNR9
Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)
Entry name TNR9 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- Transporters
- CD markers
- Predicted intracellular proteins
Transmembrane
187..213; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificblood vesselBrain Regional SpecificmidbrainCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificmidbrain-derived inhibitory
Function & Pathway7
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- Transporters
- CD markers
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence65
Ligand-Receptor Signaling (62)
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| receptor | receptor | EMBRACE | No | Yes | No | Yes | No |
| tumor_necrosis_factor | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38321535 |
Sequence, Structure & Domains9
Sequences
Length
255
Mass
27,899
Sequence
MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL
3D Structural Models
Turn
39..42
Helix
27..30; 97..99; 139..142
Beta Strand
35..37; 45..47; 55..58; 60..64; 72..76; 80..82; 85..88; 92..96; 101..104; 110..113; 116..119; 128..131; 145..148; 152..154; 157..159
3D Structure
X-ray crystallography (14)
Domain & Motif Annotations
Repeat
24..45; TNFR-Cys 1; 47..86; TNFR-Cys 2; 87..118; TNFR-Cys 3; 119..159; TNFR-Cys 4
Region
161..180; Disordered; 214..255; Interaction with LRR-1
Clinical Relevance1
Drugs (3)
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 40089067 | Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells. | No abstract available |