Protein detail
C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)
Protein symbol C1QBP | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteinsTransporters
Protein Function
- Transporters
- Human disease related genes:Congenital disorders of metabolism:Mitochondrial diseases
- Predicted intracellular proteins
- Potential drug targets
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
gC1Q-RgC1qRHABP1p32SF2p32
Gene Description
Complement C1q binding protein
Chromosome
17
Position
5432777-5448830
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain SpecificastrocyteSecretome LocationIntracellular and membraneSecretome FunctionOther
Function & Pathway
Protein Function
- Transporters
- Human disease related genes:Congenital disorders of metabolism:Mitochondrial diseases
- Predicted intracellular proteins
- Potential drug targets
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Cellular Component
Molecular Function
- GO:0001849 complement component C1q complex binding
- GO:0003714 transcription corepressor activity
- GO:0003729 mRNA binding
- GO:0004857 enzyme inhibitor activity
- GO:0005515 protein binding
- GO:0005540 hyaluronic acid binding
- GO:0008134 transcription factor binding
- GO:0030984 kininogen binding
- GO:0031690 adrenergic receptor binding
- GO:0060703 deoxyribonuclease inhibitor activity
- GO:0097177 mitochondrial ribosome binding
Biological Process
Reactome
- R-hsa-109581 apoptosis
- R-hsa-111471 apoptotic factor mediated response
- R-hsa-9734009 defective intrinsic pathway for apoptosis
- R-hsa-9645723 diseases of programmed cell death
- R-hsa-140877 formation of fibrin clot clotting cascade
- R-hsa-109582 hemostasis
- R-hsa-109606 intrinsic pathway for apoptosis
- R-hsa-140837 intrinsic pathway of fibrin clot formation
- R-hsa-5357801 programmed cell death
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| C1QBP | MMP14 | P50281 | G | 152 | cleavage | HPRD | HPRD:11773076 |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellTalkDB | No | Yes | Yes | No | No |
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| C1QBP | Q07021 | COMPLEX:P02745_P02746_P02747 | Yes | No | Yes | SIGNOR | SIGNOR:28018340 | |
| C1QBP | Q07021 | C1QB | P02746 | Yes | No | Yes | SIGNOR | SIGNOR:28018340 |
| C1QBP | Q07021 | C1QA | P02745 | Yes | No | Yes | HPRDSIGNORIntAct | IntAct:34804054SIGNOR:28018340HPRD:8195709IntAct:28018340 |
| C1QBP | Q07021 | C1QC | P02747 | Yes | No | Yes | SIGNOR | SIGNOR:28018340 |
| C1QBP | Q07021 | K2C1 | P04264 | Yes | Yes | No | SIGNOR | SIGNOR:14691569 |
Protein Complex Composition
19 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| C1QBPCOX7A2FBLGIGYF2U2AF2 | P14406P22087P26368Q07021Q6Y7W6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5901 | ||
| C1QBPRRM1SGSHYBX3 | P16989P23921P51688Q07021 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_225 | ||
| ARMH3C1QBPCDC5LCIR1NDRG3RBM39RNPS1SNW1SREK1SRSF2U2AF1U2AF2 | P26368Q01081Q01130Q07021Q13573Q14498Q15287Q5T2E6Q86X95Q8WXA9Q99459Q9UGV2 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8643 | ||
| C1QBPCUL2ELOBLRR1RBX1STAT5AVHL | P40337P42229P62877Q07021Q13617Q15370Q96L50 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4483 | ||
| C1QBPLUC7LPRPF38BSRPK1SRPK2 | P78362Q07021Q5VTL8Q96SB4Q9NQ29 | 0:0:0:0:0 | hu.MAP2 | |||
| C1QBP | Q07021 | 3 | PDB | PDB:3rpxPDB:1p32 | ||
| C1QBPLBR | Q07021Q14739 | 0:0 | hu.MAP2 | |||
| C1QBPLBRRSPO1ZNF579 | Q07021Q14739Q2MKA7Q8NAF0 | 0:0:0:0 | hu.MAP2 | |||
| C1QBPLBRRBM23ZNF579 | Q07021Q14739Q86U06Q8NAF0 | 0:0:0:0 | hu.MAP |
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Sequence, Structure & Domains
Sequences
Length
282
Mass
31,362
Sequence
MLPLLRCVPRVLGSSVAGLRAAAPASPFRQLLQPAPRLCTRPFGLLSVRAGSERRPGLLRPRGPCACGCGCGSLHTDGDKAFVDFLSDEIKEERKIQKHKTLPKMSGGWELELNGTEAKLVRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKVEEQEPELTSTPNFVVEVIKNDDGKKALVLDCHYPEDEVGQEDEAESDIFSIREVSFQSTGESEWKDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ
3D Structural Models
Turn
106..108
Helix
77..95; 175..177; 228..230; 233..245; 250..280
Beta Strand
110..114; 117..123; 125..134; 167..174; 180..187; 199..201; 206..213; 225..227
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Region
76..93; C1q binding; 138..164; Disordered; 168..213; Interaction with MAVS
Protein Families
MAM33 family
Sequence Similarities
Belongs to the MAM33 family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantPrimary mitochondrial disease
Drugs
Antibody
Interaction Protein
ENSG00000065978ENSG00000067606ENSG00000106153ENSG00000107625ENSG00000122859ENSG00000129245ENSG00000140988ENSG00000143815ENSG00000146963ENSG00000165732ENSG00000184304ENSG00000257103ENSG00000260596
Interaction Count
13
Interaction Dataset
intact_biogridbiogrid_bioplexintact_biogrid_bioplexintact_biogrid_opencellbiogrid_opencell