Protein detail

CD69

Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)

Entry name CD69	UniProt ID Q07108	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (2)

CD markersPredicted membrane proteins

Protein Function

CD markers

Transmembrane

41..61; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000110848

Entrez Gene Symbol

CD69

Gene Synonym

CLEC2C

Gene Description

CD69 molecule

Chromosome

Position

9752486-9760901

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Cell SpecificAdipocytesSingle-Nuclei Brain Specificfibroblast

Function & Pathway5

Protein Function

CD markers

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence43

Ligand-Receptor Signaling (41)

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CD69	Q07108	2	PDB	PDB:1e8iPDB:3hupPDB:3cck

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	36550367

Sequence, Structure & Domains9

Sequences

Length

199

Mass

22,559

Sequence

MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK

3D Structural Models

Turn

115..117

Helix

106..114; 126..136

Beta Strand

90..92; 95..99; 141..147; 153..155; 168..170; 172..177; 180..184; 190..197

3D Structure

Electron microscopy (1); X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)

92..195; C-type lectin

Region

1..29; Disordered

Clinical Relevance2

Drugs (6)

FUROSEMIDE PIRETANIDE BENDAMUSTINE ANTINEOPLASTIC ANTIBIOTIC BUMETANIDE TOCILIZUMAB

Antibody (2)

CAB002503 HPA050525

Supporting Publications1

PMID	Title	Abstract
38902710	Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer.	Circulating exosomes were collected from serum collected from 30 LCa patients and 20 healthy volunteers by the use of antibody affinity method exploiting CD63 specific surface marker.