Protein detail
LRP1
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Entry name LRP1 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count 1 | Protein classification Candidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Protein Class
Candidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Candidate cardiovascular disease genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Transmembrane
4420..4444; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
A2MRAPOERAPRCD91IGFBP-3RIGFBP3R1LRPLRP1A
Gene Description
LDL receptor related protein 1
Chromosome
12
Position
57128483-57213361
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificovaryCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Candidate cardiovascular disease genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Cellular Component
- GO:0005634 nucleus
- GO:0005765 lysosomal membrane
- GO:0005769 early endosome
- GO:0005794 Golgi apparatus
- GO:0005815 microtubule organizing center
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0005925 focal adhesion
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0030666 endocytic vesicle membrane
- GO:0043235 receptor complex
- GO:0098797 plasma membrane protein complex
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0003723 RNA binding
- GO:0005041 low-density lipoprotein particle receptor activity
- GO:0005044 scavenger receptor activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0016964 alpha-2 macroglobulin receptor activity
- GO:0030226 apolipoprotein receptor activity
- GO:0032050 clathrin heavy chain binding
- GO:0034185 apolipoprotein binding
- GO:0038023 signaling receptor activity
- GO:0038024 cargo receptor activity
- GO:0043395 heparan sulfate proteoglycan binding
- GO:0044877 protein-containing complex binding
- GO:0070325 lipoprotein particle receptor binding
Biological Process
KEGG
Reactome
- R-hsa-2173782 binding and uptake of ligands by scavenger receptors
- R-hsa-6806667 metabolism of fat soluble vitamins
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-2168880 scavenging of heme from plasma
- R-hsa-9709957 sensory perception
- R-hsa-5653656 vesicle mediated transport
- R-hsa-2187338 visual phototransduction
Canonical Pathways
- M5883 Naba secreted factors
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
15 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LRP1 | SRC | P12931 | Y | 4,507 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12789267phosphoELM:12789267HPRD:11854294KEA:12789267ProtMapper:12789267HPRD:12789267KEA:11854294 |
| LRP1 | SRC | P12931 | Y | 4,473 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:18381291ProtMapper:18381291 |
| LRP1 | PRKCA | P17252 | S | 4,517 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:15272003ProtMapper:15272003 |
| LRP1 | PRKCA | P17252 | S | 4,523 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:15272003ProtMapper:15272003 |
| LRP1 | PRKCA | P17252 | T | 4,460 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:15272003ProtMapper:15272003 |
| LRP1 | PRKCA | P17252 | S | 4,520 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:15272003ProtMapper:15272003 |
| LRP1 | PRKACA | P17612 | S | 4,520 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:11158305KEA:12069755HPRD:19651622SIGNOR:11158305KEA:11158305ProtMapper:11158305 |
| LRP1 | PRKACA | P17612 | S | 4,517 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| LRP1 | FURIN | P09958 | R | 3,943 | cleavage | HPRD | HPRD:2112085HPRD:8546712 |
| LRP1 | PRKX | P51817 | S | 4,517 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP |
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Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| low_density_lipoprotein | receptor | Almen2009 | No | Yes | No | Yes | No |
| ldlr | receptor | Surfaceome | No | Yes | No | Yes | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | LRP1 | Q07954 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:15272003ProtMapper:15272003PhosphoSite:15272003 |
| KAPCA | P17612 | LRP1 | Q07954 | Yes | Yes | No | phosphoELM_MIMPAdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | PhosphoSite:11158305HPRD:11158305KEA:12069755ProtMapper:19651622HPRD-phos:11158305SIGNOR:11158305KEA:11158305HPRD-phos:19651622ProtMapper:11158305Adhesome:11158305 |
| THRB | P00734 | LRP1 | Q07954 | Yes | Yes | No | WangSIGNOR | SIGNOR:8626456 |
| SRC | P12931 | LRP1 | Q07954 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALi2012HPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteAdhesomeHPRD-phos | PhosphoSite:21650223HPRD-phos:11854294SIGNOR:18381291ProtMapper:11854294KEA:11854294PhosphoSite:11854294SIGNOR:12789267phosphoELM:12789267HPRD:11854294KEA:12789267Adhesome:11854294PhosphoSite:18381291ProtMapper:12789267HPRD:12789267ProtMapper:18381291Adhesome:12789267HPRD-phos:12789267 |
| ANT3 | P01008 | LRP1 | Q07954 | Yes | Yes | No | Fantom5_LRdbHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | connectomeDB2020:8626456connectomeDB2020:14596620Cellinker:8626456Cellinker:14596620LRdb:146LRdb:8626456SIGNOR:8626456 |
| A1AT | P01009 | LRP1 | Q07954 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbHPRD_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HPRDHPRD_talklrCellinkerWangLRdbHPMR_talklr | Cellinker:15131125connectomeDB2020:8626456Cellinker:8626456HPRD:15131125LRdb:151CellTalkDB:8626456LRdb:8626456connectomeDB2020:15131125SIGNOR:8626456 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing | 8 | 37886648326797593834317239363010402224574059556439277144 3902533732002171 |
Sequence, Structure & Domains
Sequences
Length
4,544
Mass
504,606
Sequence
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07954-1; Sequence=Displayed; Name=2; IsoId=Q07954-2; Sequence=VSP_056919, VSP_056920
Alternative Sequence
281..292; HVEQMAIDWLTG -> LCVFSKSQQEMG (in isoform 2); 293..4544; Missing (in isoform 2)
3D Structural Models
Turn
853..857; 862..864; 878..881; 944..946; 964..968; 969..971; 985..987; 1070..1072; 1092..1096; 2782..2785; 2790..2794
Helix
869..871; 1030..1032; 1044..1046; 1048..1051; 1078..1080; 2804..2806; 2808..2810
Beta Strand
859..861; 865..867; 874..876; 934..936; 940..942; 948..950; 953..956; 958..961; 974..976; 978..983; 989..991; 995..1000; 1003..1007; 1009..1011; 1013..1015; 1019..1021; 1027..1029; 1035..1037; 1040..1043; 1081..1085; 1088..1091; 2778..2781; 2786..2789; 2795..2797; 2800..2803; 2813..2816
3D Structure
NMR spectroscopy (6); X-ray crystallography (1)
Domain & Motif Annotations
Repeat
292..334; LDL-receptor class B 1; 335..378; LDL-receptor class B 2; 379..422; LDL-receptor class B 3; 571..613; LDL-receptor class B 4; 614..659; LDL-receptor class B 5; 660..710; LDL-receptor class B 6; 711..754; LDL-receptor class B 7; 1309..1355; LDL-receptor class B 8; 1356..1398; LDL-receptor class B 9; 1399..1445; LDL-receptor class B 10; 1446..1490; LDL-receptor class B 11; 1491..1531; LDL-receptor class B 12; 1627..1669; LDL-receptor class B 13; 1670..1713; LDL-receptor class B 14; 1714..1753; LDL-receptor class B 15; 1754..1798; LDL-receptor class B 16; 1934..1976; LDL-receptor class B 17; 1977..2019; LDL-receptor class B 18; 2020..2063; LDL-receptor class B 19; 2064..2107; LDL-receptor class B 20; 2253..2294; LDL-receptor class B 21; 2295..2343; LDL-receptor class B 22; 2344..2388; LDL-receptor class B 23; 2389..2431; LDL-receptor class B 24; 2432..2473; LDL-receptor class B 25; 3069..3113; LDL-receptor class B 26; 3114..3156; LDL-receptor class B 27; 3157..3200; LDL-receptor class B 28; 3201..3243; LDL-receptor class B 29; 3244..3284; LDL-receptor class B 30; 3912..3954; LDL-receptor class B 31; 3970..4012; LDL-receptor class B 32; 4013..4056; LDL-receptor class B 33; 4057..4101; LDL-receptor class B 34
Motif
3940..3943; Recognition site for proteolytical processing; 4502..4507; NPXY motif
Domain (FT)
25..66; LDL-receptor class A 1; 70..110; LDL-receptor class A 2; 111..149; EGF-like 1; 150..189; EGF-like 2; calcium-binding; 474..520; EGF-like 3; 803..843; EGF-like 4; 852..892; LDL-receptor class A 3; 893..933; LDL-receptor class A 4; 934..973; LDL-receptor class A 5; 974..1013; LDL-receptor class A 6; 1013..1053; LDL-receptor class A 7; 1060..1099; LDL-receptor class A 8; 1102..1142; LDL-receptor class A 9; 1143..1182; LDL-receptor class A 10; 1183..1222; EGF-like 5; 1223..1262; EGF-like 6; 1536..1579; EGF-like 7; 1846..1887; EGF-like 8; 2155..2195; EGF-like 9; 2478..2518; EGF-like 10; 2522..2563; LDL-receptor class A 11; 2564..2602; LDL-receptor class A 12; 2603..2641; LDL-receptor class A 13; 2642..2690; LDL-receptor class A 14; 2694..2732; LDL-receptor class A 15; 2732..2771; LDL-receptor class A 16; 2772..2814; LDL-receptor class A 17; 2816..2855; LDL-receptor class A 18; 2856..2899; LDL-receptor class A 19; 2902..2940; LDL-receptor class A 20; 2941..2981; EGF-like 11; 2982..3022; EGF-like 12; calcium-binding; 3290..3331; EGF-like 13; 3332..3371; LDL-receptor class A 21; 3372..3410; LDL-receptor class A 22; 3411..3450; LDL-receptor class A 23; 3451..3491; LDL-receptor class A 24; 3492..3533; LDL-receptor class A 25; 3534..3572; LDL-receptor class A 26; 3573..3611; LDL-receptor class A 27; 3611..3649; LDL-receptor class A 28; 3652..3692; LDL-receptor class A 29; 3693..3733; LDL-receptor class A 30; 3739..3778; LDL-receptor class A 31; 3781..3823; EGF-like 14; 3824..3861; EGF-like 15; 4147..4183; EGF-like 16; 4196..4232; EGF-like 17; 4232..4268; EGF-like 18; 4268..4304; EGF-like 19; 4304..4340; EGF-like 20; 4340..4375; EGF-like 21; 4373..4409; EGF-like 22
Region
4445..4544; Interaction with MAFB
Protein Families
LDLR family
Sequence Similarities
Belongs to the LDLR family.
Clinical Relevance
Disease Involvement
Disease variant
Interaction Protein
ENSG00000146648ENSG00000163956ENSG00000166313
Interaction Count
3
Interaction Dataset
intact_biogrid