Protein detail
PCDH1
Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42)
Protein symbol PCDH1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
853..873; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
pc42
Gene Description
Protocadherin 1
Chromosome
5
Position
141853090-141879246
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEsophageal apical cellsBlood Cell Specificneutrophil
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PCDH1 | CDK1 | P06493 | S | 962 | phosphorylation | KEA | KEA:17570479 |
| PCDH1 | GSK3B | P49841 | S | 962 | phosphorylation | KEA | KEA:17570479 |
| PCDH1 | MAPK8 | P45983 | S | 962 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PCDH17 | O14917 | 4 | PDB | PDB:6vft | ||
| CLIC3PCDH10PCDH12PCDH17 | O14917O95833Q9NPG4Q9P2E7 | 0:0:0:0 | hu.MAP2 | |||
| PCDH19 | Q8TAB3 | 3 | PDB | PDB:6vfu | ||
| PCDH15 | Q96QU1 | 2 | PDB | PDB:6eb5PDB:5ulyPDB:5t4mPDB:5t4nPDB:6e8f | ||
| PCDH18 | Q9HCL0 | 2 | PDB | PDB:6vfr | ||
| PCDH10 | Q9P2E7 | 5 | PDB | PDB:6vfw |
Sequence, Structure & Domains
Sequences
Length
1,060
Mass
114,743
Sequence
MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08174-1; Sequence=Displayed; Name=2; Synonyms=PC42-8; IsoId=Q08174-2; Sequence=VSP_000703
Alternative Sequence
1034..1060; VGQPFQLSTPQPLPHPYHGAIWTEVWE -> LPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENDLRPLPDVAMTGTCTRECSEFGHSDTCWMPGQSSPSRRTKSSALKLSTFVPYQDRGGQEPAGAGSPSPPEDRNTKTAPVRLLPSYSAFSHSSHDSCKDSATLEEIPLTQTSDFPPAATPASAQTAKREIYL (in isoform 2)
3D Structural Models
Turn
96..98; 103..106; 117..119; 240..242; 334..336; 347..349; 466..468
Helix
77..79; 121..123; 198..200; 211..214; 310..312; 324..329; 425..428
Beta Strand
63..67; 73..75; 90..94; 99..102; 107..110; 128..130; 132..140; 143..145; 150..159; 169..178; 186..188; 201..208; 217..222; 229..234; 245..258; 261..271; 279..290; 298..301; 315..321; 330..332; 338..341; 351..361; 363..365; 368..378; 386..390; 401..403; 413..420; 431..434; 439..444; 446..448; 453..462; 472..479; 487..495
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
884..897; Basic and acidic residues; 907..920; Basic residues; 973..986; Low complexity; 1003..1024; Polar residues; 1033..1043; Polar residues
Domain (FT)
58..168; Cadherin 1; 169..280; Cadherin 2; 281..387; Cadherin 3; 396..506; Cadherin 4; 507..612; Cadherin 5; 613..715; Cadherin 6; 718..844; Cadherin 7
Region
884..1045; Disordered