Protein detail
S20A2
Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)
Protein symbol S20A2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Transmembrane
6..26; Helical; 47..67; Helical; 87..107; Helical; 110..130; Helical; 143..163; Helical; 191..211; Helical; 214..234; Helical; 483..503; Helical; 531..551; Helical; 572..586; Helical; 594..609; Helical; 622..642; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
Glvr-2GLVR2MLVARPiT-2Ram-1
Gene Description
Solute carrier family 20 member 2
Chromosome
8
Position
42416475-42541926
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificRetinal amacrine cellsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ATP13A1GPAA1PIGKPIGSPIGTSLC20A2SLC22A5SV2AUBC | O43292O76082P0CG48Q08357Q7L0J3Q92643Q969N2Q96S52Q9HD20 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4390 | ||
| ATP13A1GPAA1PIGKPIGSPIGTSLC20A2SV2AUBC | O43292P0CG48Q08357Q7L0J3Q92643Q969N2Q96S52Q9HD20 | 1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5816 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass Spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
652
Mass
70,392
Sequence
MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
3D Structural Models
Domain & Motif Annotations
Compositional Bias
295..304; Polar residues
Region
273..307; Disordered; 458..477; Disordered
Protein Families
Inorganic phosphate transporter (PiT) (TC 2.A.20) family
Sequence Similarities
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
Clinical Relevance
Disease Involvement
Disease variant
Antibody