Protein detail
CD47
Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
Protein symbol CD47 | UniProt ID | EVMP score 0.88 |
Frequency 29 | Transmembrane count 5 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
Protein Class
CD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- CD markers
- Predicted intracellular proteins
Transmembrane
142..162; Helical; 177..197; Helical; 208..228; Helical; 236..256; Helical; 269..289; Helical
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Gene Synonym
IAPMER6OA3
Gene Description
CD47 molecule
Chromosome
3
Position
108043091-108091862
Frequency
29
EVMP Score
0.88
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificMegakaryocytesSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1500931 cell cell communication
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
- R-hsa-6798695 neutrophil degranulation
- R-hsa-391160 signal regulatory protein family interactions
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | Adhesome | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TSP2 | P35442 | CD47 | Q08722 | Yes | Yes | No | CellChatDBFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020UniProt_LRdbCellinkerWangLRdbHPMR_talklr | Cellinker:8550562LRdb:8550562connectomeDB2020:8550562CellTalkDB:8550562SIGNOR:8550562 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37438638 |
Sequence, Structure & Domains
Sequences
Length
323
Mass
35,214
Sequence
MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=OA3-323; IsoId=Q08722-1; Sequence=Displayed; Name=OA3-293; IsoId=Q08722-2; Sequence=VSP_002535; Name=OA3-305; IsoId=Q08722-3; Sequence=VSP_002536, VSP_002537; Name=OA3-312; IsoId=Q08722-4; Sequence=VSP_002538
Alternative Sequence
293..323; Missing (in isoform OA3-293); 304..305; KA -> NN (in isoform OA3-305); 306..323; Missing (in isoform OA3-305); 312..323; Missing (in isoform OA3-312)
3D Structural Models
Turn
139..143; 254..260
Helix
51..53; 70..72; 79..81; 88..93; 102..106; 144..164; 178..196; 204..224; 238..253; 268..292
Beta Strand
26..30; 35..39; 42..45; 54..60; 63..69; 74..76; 98..101; 110..118; 121..131; 197..202; 261..264
3D Structure
X-ray crystallography (15)
Domain & Motif Annotations
Domain (FT)
19..127; Ig-like V-type
Clinical Relevance
Related Diseases
Acute myeloid leukaemiaB-cell lymphomaColorectal cancerDiffuse large B-cell lymphomaLeukaemiaLymphomaMalignant haematopoietic neoplasmMelanomaMultiple myelomaMycosis fungoidesMyelodysplastic syndromeNeuroendocrine carcinomaNon-small-cell lung cancerOvarian cancerSolid tumour/cancerSquamous cell carcinomaStomach cancer
Biomarker
Phase 1; Phase 1/2; Phase 2; Phase 3; Phase 2/3