Protein detail
SPIR1
Protein spire homolog 1 (Spir-1)
Entry name SPIR1 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein spire homolog 1 (Spir-1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1135spir-1
Gene Description
Spire type actin nucleation factor 1
Chromosome
18
Position
12446512-12658107
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificChoroid plexus epithelial cellsBlood Cell Specificneutrophil
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass Spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
756
Mass
85,544
Sequence
MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEGLGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLAMRPLSMSYSFDLSDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q08AE8-1; Sequence=Displayed; Name=5; IsoId=Q08AE8-5; Sequence=VSP_054464, VSP_052595; Name=2; IsoId=Q08AE8-2; Sequence=VSP_052595; Name=3; IsoId=Q08AE8-3; Sequence=VSP_037925, VSP_052595; Name=4; IsoId=Q08AE8-4; Sequence=VSP_037925, VSP_052595, VSP_037926
Alternative Sequence
1..159; Missing (in isoform 3 and isoform 4); 1..120; Missing (in isoform 5); 397..410; Missing (in isoform 2, isoform 3, isoform 4 and isoform 5); 616..756; RPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI -> SDCLFNGTAHCQFYLG (in isoform 4)
3D Structural Models
Turn
138..140
Helix
42..49; 55..74; 85..87; 122..137; 151..160; 196..204; 210..212; 213..234
Beta Strand
38..41; 88..91; 96..98; 116..120; 145..147; 207..209
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
425..447; Polar residues; 474..492; Low complexity; 512..528; Basic and acidic residues; 529..538; Polar residues
Coiled Coil
229..257
Domain (CC)
Binds to actin monomers via the WH2 domain.; DOMAIN: The Spir-box targets binding to intracellular membrane structures.
Domain (FT)
40..231; KIND; 305..323; WH2 1; 369..386; WH2 2
Region
1..35; Disordered; 131..138; Important for interaction with FMN2; 425..538; Disordered; 556..576; Spir-box
Protein Families
Spire family
Sequence Similarities
Belongs to the spire family.