Protein detail

SIG14

Sialic acid-binding Ig-like lectin 14 (Siglec-14)

Entry name SIG14	UniProt ID Q08ET2	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Sialic acid-binding Ig-like lectin 14 (Siglec-14)

Protein Class (2)

Plasma proteinsPredicted membrane proteins

Transmembrane

359..381; Helical

Transmembrane Count

Ensembl

ENSG00000254415

Entrez Gene Symbol

SIGLEC14

Gene Description

Sialic acid binding Ig like lectin 14

Chromosome

Position

51639478-51646825

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecifickidneyCell SpecificPlateletsBlood Cell Specificmemory B-cell

Function & Pathway5

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence26

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
ig_like	adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	38207106 38716512

Sequence, Structure & Domains7

Sequences

Length

396

Mass

43,970

Sequence

MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG

Domain & Motif Annotations

Domain (FT)

19..136; Ig-like V-type; 146..229; Ig-like C2-type 1; 236..331; Ig-like C2-type 2

Region

190..209; Disordered

Protein Families (2)

Immunoglobulin superfamily
SIGLEC (sialic acid binding Ig-like lectin) family

Sequence Similarities

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Clinical Relevance1

Antibody (2)

HPA014377 HPA014428

Supporting Publications1

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available