Protein detail
SIG14
Sialic acid-binding Ig-like lectin 14 (Siglec-14)
Entry name SIG14 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Sialic acid-binding Ig-like lectin 14 (Siglec-14)
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Transmembrane
359..381; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Sialic acid binding Ig like lectin 14
Chromosome
19
Position
51639478-51646825
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificPlateletsBlood Cell Specificmemory B-cell
Function & Pathway
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence26
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | Yes | |||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| ig_like | adhesion | Almen2009 | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | ||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes |
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Sequence, Structure & Domains
Sequences
Length
396
Mass
43,970
Sequence
MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG
Domain & Motif Annotations
Domain (FT)
19..136; Ig-like V-type; 146..229; Ig-like C2-type 1; 236..331; Ig-like C2-type 2
Region
190..209; Disordered
Protein Families (2)
- Immunoglobulin superfamily
- SIGLEC (sialic acid binding Ig-like lectin) family
Sequence Similarities
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No related sentences available |