Protein detail
DMWD
Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9)
Protein symbol DMWD | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
D19S593EDMR-N9gene59
Gene Description
DM1 locus, WD repeat containing
Chromosome
19
Position
45782947-45792845
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificAlveolar cells type 1Blood Cell Specificneutrophil
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M212 Pid integrin5 pathway
- M53 Pid integrin3 pathway
- M160 Pid avb3 integrin pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| USP12-DMWD deubiquitinase complex | DMWDUSP12WDR48 | O75317Q09019Q8TAF3 | 1:1:1 | ComplexPortal | PDB:5K1APDB:5K1Bintact:EBI-55026239 | 338444682737333614755292 |
| DMWDGAK | O14976Q09019 | 0:0 | hu.MAP | |||
| DMWDRAD51AP1USP1USP46VSX2WDR20WDR48 | O94782P58304P62068Q09019Q8TAF3Q8TBZ3Q96B01 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| DMWDF7SLX4VARS1 | P08709P26640Q09019Q8IY92 | 1:1:1:1 | CompleatCFinder | Compleat:HC7148 | ||
| DMWDUSP46 | P62068Q09019 | 0:0 | hu.MAP2 | |||
| DMWDUSP46WDR20WDR48 | P62068Q09019Q8TAF3Q8TBZ3 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
674
Mass
70,438
Sequence
MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEGISSQPGNSPSGTVV
3D Structural Models
Domain & Motif Annotations
Compositional Bias
53..65; Pro residues; 66..77; Low complexity; 78..90; Pro residues; 107..118; Low complexity; 457..478; Low complexity; 487..499; Low complexity; 500..509; Gly residues; 550..563; Gly residues; 642..674; Polar residues
Repeat
211..251; WD 1; 282..321; WD 2; 324..363; WD 3; 366..409; WD 4; 413..453; WD 5; 601..638; WD 6
Region
31..92; Disordered; 103..122; Disordered; 384..419; Disordered; 456..516; Disordered; 532..573; Disordered; 637..674; Disordered