Protein detail
ARHG5
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
Protein symbol ARHG5 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Essential proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
Protein Class
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GEF5P60TIMTIM1
Gene Description
Rho guanine nucleotide exchange factor 5
Chromosome
7
Position
144355288-144380632
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificdeep-layer corticothalamic and 6bBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Canonical Pathways
- M145 Pid p53 downstream pathway
- M5883 Naba secreted factors
- M5885 Naba matrisome associated
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | ARHG5 | Q12774 | Yes | Yes | No | SIGNOR | SIGNOR:21525037 |
| ARHG5 | Q12774 | RHOA | P61586 | Yes | Yes | No | SIGNORCui2007HINTWangSPIKE_LC | HINT:12006984SPIKE_LC:17145710HINT:34591642HINT:32203420SIGNOR:32203420 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
1,597
Mass
176,799
Sequence
MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLAPPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=A number of additional isoforms are detected in primary breast tumors but not in normal tissues.; Name=1; IsoId=Q12774-1; Sequence=Displayed; Name=2; IsoId=Q12774-2; Sequence=VSP_035175
Alternative Sequence
1..1078; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
192..204; Polar residues; 217..237; Low complexity; 266..278; Basic and acidic residues; 299..309; Acidic residues; 323..368; Basic and acidic residues; 394..404; Basic and acidic residues; 428..438; Polar residues; 474..490; Basic and acidic residues; 512..522; Pro residues; 583..601; Polar residues; 655..682; Polar residues; 731..746; Basic and acidic residues; 812..828; Pro residues; 838..856; Pro residues; 901..920; Low complexity; 926..941; Polar residues; 950..969; Basic and acidic residues; 990..1012; Basic and acidic residues; 1057..1072; Basic and acidic residues
Domain (CC)
The PH domain binds to phosphoinositides and is essential for podosome formation.
Domain (FT)
1174..1358; DH; 1390..1502; PH; 1510..1571; SH3
Region
138..246; Disordered; 258..455; Disordered; 467..1072; Disordered