Protein detail
KCMA1
Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
Protein symbol KCMA1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
Basic Information
Protein Names
Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
87..107; Helical; Name=Segment S0; 179..199; Helical; Name=Segment S1; 215..235; Helical; Name=Segment S2; 240..260; Helical; Name=Segment S3; 265..285; Helical; Name=Segment S4; 301..321; Helical; Name=Segment S5; 368..388; Helical; Name=Segment S6
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
KCa1.1mSLO1SLO
Gene Description
Potassium calcium-activated channel subfamily M alpha 1
Chromosome
10
Position
76869601-77638369
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9667769 acetylcholine inhibits contraction of outer hair cells
- R-hsa-1296052 ca2 activated k channels
- R-hsa-418457 cgmp effects
- R-hsa-109582 hemostasis
- R-hsa-112316 neuronal system
- R-hsa-392154 nitric oxide stimulates guanylate cyclase
- R-hsa-418346 platelet homeostasis
- R-hsa-1296071 potassium channels
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KCNMA1 | PRKCA | P17252 | S | 1,200 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:19592459SIGNOR:19592459 |
| KCNMA1 | PRKG2 | Q13237 | S | 1,195 | phosphorylation | Reactome_ProtMapperProtMapper | |
| KCNMA1 | PRKG1 | Q13976 | S | 1,195 | phosphorylation | Reactome_ProtMapperProtMapper | |
| KCNMA1 | GSK3B | P49841 | S | 924 | phosphorylation | KEA | KEA:17570479 |
| KCNMA1 | MAPK8 | P45983 | S | 924 | phosphorylation | KEA | KEA:17570479 |
| KCNMA1 | PRKACA | P17612 | S | 934 | phosphorylation | KEA | KEA:11749379 |
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | KCMA1 | Q12791 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:19592459PhosphoSite:19592459SIGNOR:19592459 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| KCNMA1 | Q12791 | 4 | PDB | PDB:8v64PDB:8ghfPDB:8z3sPDB:6nd0PDB:8v60PDB:8v63PDB:6v38PDB:7yo2PDB:7yo5PDB:9jo4PDB:8gh9PDB:8ghgPDB:6v3gPDB:9jo3 | ||
| KCNMA1KCNMB4 | Q12791Q86W47 | 4:4 | PDB | PDB:9czoPDB:6v22PDB:9czhPDB:9czqPDB:9czkPDB:9czmPDB:9d19PDB:9d18PDB:6v35PDB:9czj |
Sequence, Structure & Domains
Sequences
Length
1,236
Mass
137,560
Sequence
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
Alternative Products
Event=Alternative splicing; Named isoforms=7; Comment=May be partially controlled by hormonal stress. Additional isoforms seem to exist.; Name=1; Synonyms=SAKCA; IsoId=Q12791-1; Sequence=Displayed; Name=2; Synonyms=BKTM; IsoId=Q12791-2; Sequence=VSP_009955, VSP_009958; Name=3; IsoId=Q12791-3; Sequence=VSP_009954; Name=4; Synonyms=hbr5; IsoId=Q12791-4; Sequence=VSP_009956; Name=5; IsoId=Q12791-5; Sequence=VSP_009955; Name=6; IsoId=Q12791-6; Sequence=VSP_009952, VSP_009953; Name=7; Synonyms=gBK; IsoId=Q12791-7; Sequence=VSP_009957
Alternative Sequence
127..168; EAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGV -> ATHFGSPEMPPAARSWSGSPPEAAVLRGASSLALEVARCRRL (in isoform 6); 169..1236; Missing (in isoform 6); 643; R -> RSRKR (in isoform 3); 698..756; PKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAF -> L (in isoform 2 and isoform 5); 698..756; PKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAF -> LKVAARSRYSKDPFEFKKETPNSRLVTEPV (in isoform 4); 698..756; PKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAF -> RWEEHCSLWRLESKGNVRRLNYCRGQQTFSVKVKVAARSRYSKDPFEFKKETPNSRLVTEPV (in isoform 7); 828; L -> LVTGWMPYLGPRVLMTCLDIGVVCMPTDIQSTSPASIKKFKE (in isoform 2)
3D Structural Models
Turn
112..116; 171..173; 209..211; 679..681; 893..895; 930..932
Helix
87..110; 159..169; 175..198; 214..234; 239..243; 246..264; 272..281; 282..288; 295..324; 327..329; 339..350; 363..382; 384..391; 418..431; 435..437; 453..459; 473..478; 481..483; 498..515; 528..531; 532..536; 542..544; 551..564; 568..574; 589..597; 608..610; 615..626; 667..670; 672..675; 687..689; 803..805; 823..825; 830..835; 858..861; 863..865; 871..873; 883..889; 890..892; 909..914; 917..919; 937..940; 941..952; 1008..1013; 1026..1028; 1030..1033; 1040..1044; 1045..1052; 1055..1065; 1074..1079; 1089..1093; 1094..1096; 1111..1114; 1119..1130; 1141..1143
Beta Strand
203..206; 266..268; 356..358; 392..395; 409..415; 439..446; 463..468; 470..472; 485..490; 521..527; 537..539; 547..550; 586..588; 600..605; 629..634; 638..640; 644..647; 650..653; 659..665; 813..816; 842..847; 850..852; 867..869; 877..881; 896..904; 921..927; 934..936; 994..996; 1001..1007; 1016..1018; 1022..1024; 1036..1039; 1099..1104; 1106..1108; 1133..1140; 1144..1147; 1154..1159; 1171..1176
3D Structure
Electron microscopy (31); NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
1..21; Gly residues; 39..60; Low complexity; 1186..1211; Low complexity; 1220..1236; Basic and acidic residues
Motif
352..355; Selectivity for potassium; 1003..1025; Calcium bowl
Domain (CC)
The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4..; DOMAIN: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.; DOMAIN: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium.; DOMAIN: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).; DOMAIN: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors region required for activation of the channel.; DOMAIN: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation.
Domain (FT)
407..549; RCK N-terminal 1; 839..983; RCK N-terminal 2
Region
1..61; Disordered; 556..576; Segment S7; 613..633; Segment S8; 677..681; Heme-binding motif; 757..787; Disordered; 837..857; Segment S9; 1032..1052; Segment S10; 1186..1236; Disordered
Protein Families
- Potassium channel family
- Calcium-activated (TC 1.A.1.3) subfamily
- KCa1.1/KCNMA1 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Clinical Relevance
Disease Involvement
Disease variantEpilepsyFDA approved drug targets
Related Diseases
Biomarker
Phase 2
Drug Targets
FDA approved drug targets
Drugs
Antibody