Protein detail
KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1)
Entry name KCNH2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 4 | Transmembrane count 6 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1)
Protein Function (5)
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
404..424; Helical; Name=Segment S1; 451..471; Helical; Name=Segment S2; 496..516; Helical; Name=Segment S3; 521..541; Helical; Voltage-sensor; Name=Segment S4; 548..568; Helical; Name=Segment S5; 639..659; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.25
Function & Pathway6
Protein Function (5)
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component (5)
Molecular Function (10)
- GO:0000976 transcription cis-regulatory region binding
- GO:0005242 inward rectifier potassium channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0005251 delayed rectifier potassium channel activity
- GO:0005515 protein binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0097110 scaffold protein binding
- GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence51
Enzyme-Mediated Modification (13)
13 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KCNH2 | PRKACA | P17612 | S | 283 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10488078SIGNOR:10488078KEA:11953308 |
| KCNH2 | PRKACA | P17612 | S | 890 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10488078SIGNOR:10488078 |
| KCNH2 | PRKACA | P17612 | T | 895 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10488078SIGNOR:10488078 |
| KCNH2 | PRKACA | P17612 | S | 1,137 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10837251SIGNOR:10488078HPRD:11953308HPRD:10837251HPRD:19651622KEA:11953308ProtMapper:10488078 |
| KCNH2 | PRKACA | P17612 | S | 797 | phosphorylation | HPRDKEA | KEA:10837251HPRD:11953308HPRD:10837251HPRD:19651622KEA:11953308 |
| KCNH2 | PRKD1 | Q15139 | S | 284 | phosphorylation | PhosphoSite | |
| KCNH2 | PRKCA | P17252 | S | 890 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22653970 |
| KCNH2 | PRKX | P51817 | S | 283 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| KCNH2 | PRKX | P51817 | S | 1,137 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| KCNH2 | PRKY | O43930 | S | 283 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
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Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 3 of 3Previous
Regulatory Interaction Network (9)
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | KCNH2 | Q12809 | Yes | Yes | No | phosphoELM_MIMPAdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | PhosphoSite:18791070ProtMapper:11953308KEA:10837251Adhesome:11953308SIGNOR:10488078HPRD:11953308HPRD:10837251KEA:11953308Adhesome:10837251HPRD-phos:10837251PhosphoSite:10488078ProtMapper:19651622ProtMapper:10488078PhosphoSite:10837251ProtMapper:10837251PhosphoSite:11953308HPRD-phos:19651622HPRD-phos:11953308 |
| ITB1 | P05556 | KCNH2 | Q12809 | Yes | Yes | No | WangSIGNORAdhesome | Adhesome:15494025SIGNOR:35442831 |
| KCNH2 | Q12809 | ITB1 | P05556 | Yes | Yes | No | WangSIGNORAdhesome | Adhesome:15494025SIGNOR:35442831 |
| NED4L | Q96PU5 | KCNH2 | Q12809 | Yes | No | Yes | SIGNORBioGRID | BioGRID:24688054SIGNOR:21463633BioGRID:22879586 |
| PTN6 | P29350 | KCNH2 | Q12809 | Yes | No | Yes | SIGNOR | SIGNOR:12361947 |
| KPCD1 | Q15139 | KCNH2 | Q12809 | Yes | No | Yes | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:29949809SIGNOR:29949809 |
| MINK1 | Q8N4C8 | KCNH2 | Q12809 | Yes | Yes | No | SIGNOR | SIGNOR:9230439 |
| NEDD4 | P46934 | KCNH2 | Q12809 | Yes | No | Yes | SIGNOR | SIGNOR:26363003 |
| KPCA | P17252 | KCNH2 | Q12809 | Yes | No | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22653970ProtMapper:22653970 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| KCNE1-KCNH2 complex | KCNE1KCNH2 | P15382Q12809 | 1:1 | CORUMComplexPortal | CORUM:6571 | 147552929230439 |
| KCNE2-KCNH2 complex | KCNE2KCNH2 | Q12809Q9Y6J6 | 1:1 | CORUMComplexPortal | CORUM:6578 | 1021923914755292 |
| KCNH2 | Q12809 | 4 | PDB | PDB:8zynPDB:8io4PDB:8zyqPDB:8zyoPDB:8io5PDB:9chsPDB:9chrPDB:8iobPDB:8zypPDB:9chpPDB:9chq |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains17
Sequences
Length
1,159
Mass
126,655
Sequence
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS
Alternative Products
Event=Alternative splicing; Named isoforms=6; Comment=Experimental confirmation may be lacking for some isoforms.; Name=A; Synonyms=KCNH2-1A; IsoId=Q12809-1; Sequence=Displayed; Name=B; Synonyms=HERG1B; IsoId=Q12809-2; Sequence=VSP_000965; Name=4; IsoId=Q12809-4; Sequence=VSP_000966; Name=A-USO; Synonyms=HERG1USO; IsoId=Q12809-5; Sequence=VSP_047880, VSP_047881; Name=B-USO; Synonyms=HERG1BUSO; IsoId=Q12809-6; Sequence=VSP_047878, VSP_047879, VSP_047880, VSP_047881; Name=3.1; Synonyms=KCNH2-3.1; IsoId=Q12809-7; Sequence=VSP_047877
Alternative Sequence
1..376; MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQ -> MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQE (in isoform B); 1..102; MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKD -> MSSHSA (in isoform 3.1); 1..36; MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARV -> MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQE (in isoform B-USO); 37..376; Missing (in isoform B-USO); 139..195; Missing (in isoform 4); 801..888; KNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRK -> MGWGAGTGLEMPSAASRGASLLNMQSLGLWTWDCLQGHWAPLIHLNSGPPSGAMERSPTWGEAAELWGSHILLPFRIRHKQTLFASLK (in isoform A-USO and isoform B-USO); 889..1159; Missing (in isoform A-USO and isoform B-USO)
3D Structural Models
Turn
23..26; 574..577; 810..812
Helix
15..19; 46..52; 56..59; 67..69; 76..87; 405..431; 451..471; 486..495; 498..503; 508..510; 518..524; 525..531; 532..537; 539..542; 546..573; 585..592; 607..623; 635..666; 668..687; 691..708; 713..719; 723..731; 742..745; 748..756; 835..844; 848..854
Beta Strand
29..33; 36..38; 40..44; 88..90; 92..99; 105..116; 118..120; 122..134; 628..630; 735..739; 759..761; 768..770; 778..780; 783..785; 787..793; 795..799; 819..821; 830..834; 859..861
3D Structure
Electron microscopy (14); NMR spectroscopy (6); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
258..269; Polar residues; 883..892; Basic residues; 928..939; Low complexity; 960..970; Pro residues
Motif
624..629; Selectivity filter
Coiled Coil
1035..1062
Domain (CC)
The S4-S5 linker acts as a signal integrator where it both couples voltage-sensor domain (VSD) movement to pore opening and closure, as well as providing a binding site for other domains that regulate activation and/or deactivation of the channel.
Domain (FT)
41..70; PAS; 92..144; PAC
Region
231..314; Disordered; 742..842; cNMP-binding domain; 870..982; Disordered; 1015..1038; Disordered; 1119..1159; Disordered
Protein Families (3)
- Potassium channel family
- H (Eag) (TC 1.A.1.20) subfamily
- Kv11.1/KCNH2 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
Clinical Relevance3
Related Diseases (9)
Biomarker
Terminated; Discontinued in Phase 2; Investigative; Approved; Phase 2; Phase 3
Drugs (352)
LOBELINE HYDROCHLORIDECHEMBL:CHEMBL590914SERTINDOLEAZD1305CHEMBL:CHEMBL1255966BUSPIRONE HYDROCHLORIDECHLORPROMAZINE HYDROCHLORIDENORTRIPTYLINE HYDROCHLORIDESULPIRIDECHEMBL:CHEMBL602413METHOXYVERAPAMIL HYDROCHLORIDECIPARGAMINCHEMBL:CHEMBL587923CLOTRIMAZOLECHEMBL:CHEMBL1256754CHEMBL:CHEMBL581194CINNARIZINECHEMBL:CHEMBL584655CHEMBL:CHEMBL601743CHEMBL:CHEMBL1256689U101958CHEMBL:CHEMBL586026TRIFLUOPERAZINE HYDROCHLORIDETHIORIDAZINECHEMBL:CHEMBL582666CHEMBL:CHEMBL1256726DRONEDARONENYLIDRIN HYDROCHLORIDENULLFENOFIBRATE MICRONIZEDENDRINAMIODARONE HYDROCHLORIDECHEMBL:CHEMBL5472694-NONYLPHENOLCHEMBL:CHEMBL1237255PYRILAMINEPROPAFENONEVERAPAMILNICARDIPINE HYDROCHLORIDECHEMBL:CHEMBL535730PROPOFOLCHEMBL:CHEMBL261693DOFETILIDENERISPIRDINEFENOLDOPAM BROMIDECHLORPHENIRAMINE MALEATELIRANAFTATECHEMBL:CHEMBL553503NOMIFENSINE MALEATECHEMBL:CHEMBL597248CHEMBL:CHEMBL584841CITALOPRAM HYDROBROMIDETELITHROMYCINCHEMBL:CHEMBL344127OXATOMIDECHEMBL:CHEMBL529348TAMOXIFEN CITRATECHEMBL:CHEMBL587892ROPINIROLE HYDROCHLORIDECHEMBL:CHEMBL525519TRIPROLIDINE HYDROCHLORIDECHEMBL:CHEMBL317364CHEMBL:CHEMBL529984CHEMBL:CHEMBL530149IBUTILIDEPHENTOLAMINE MESYLATEPIRENPERONECHEMBL:CHEMBL586344CHEMBL:CHEMBL532141RO 8-4304RESERPINEHALOPERIDOL DECANOATECHEMBL:CHEMBL2028056GENTIAN VIOLET CATIONCHEMBL:CHEMBL582767FLUSPIRILENEGW5074OXYMETAZOLINE HYDROCHLORIDEVOLINANSERINCHEMBL:CHEMBL546531CHEMBL:CHEMBL533399SERTRALINE HYDROCHLORIDECHEMBL:CHEMBL527730CHEMBL:CHEMBL601492CHEMBL:CHEMBL592044DEXBROMPHENIRAMINE MALEATECHEMBL:CHEMBL590201TERFENADINECHEMBL:CHEMBL545880GUANABENZ ACETATEMETHAPYRILENE HYDROCHLORIDECHEMBL:CHEMBL598279APTIGANEL HYDROCHLORIDESOTALOLCHEMBL:CHEMBL608855PYRILAMINE MALEATETYRPHOSTIN AG 879CYPROHEPTADINE HYDROCHLORIDECHEMBL:CHEMBL602580CHEMBL:CHEMBL10835CARBETAPENTANE CITRATECHEMBL:CHEMBL49055BENZETHONIUM CHLORIDEPERPHENAZINEPROPIONYLPROMAZINE HYDROCHLORIDECHEMBL:CHEMBL602940GR 89696PROADIFEN HYDROCHLORIDECHEMBL:CHEMBL589920BP 897CHEMBL:CHEMBL1623028CHEMBL:CHEMBL600030DOMPERIDONECHEMBL:CHEMBL584829PERGOLIDE MESYLATECHEMBL:CHEMBL591641DISOPYRAMIDELOPERAMIDECHEMBL:CHEMBL1623897CALCIUM CHANNEL BLOCKERCLOMIPRAMINE HYDROCHLORIDEATENOLOLMETHIOTHEPIN MESYLATECHEMBL:CHEMBL590919QUINIDINEMIBEFRADIL DIHYDROCHLORIDECHEMBL:CHEMBL592332CHEMBL:CHEMBL1257031IOFETAMINE HYDROCHLORIDECHEMBL:CHEMBL544115BUTACLAMOL HYDROCHLORIDEDIPHENHYDRAMINE HYDROCHLORIDECHEMBL:CHEMBL581187BROMOENOL LACTONEBUDIODARONEAMOXAPINECAPTANFLUNARIZINE HYDROCHLORIDEL-162,313VANOXERINETEDISAMILKEPONEPHENYLMERCURIC ACETATECHEMBL:CHEMBL598270CHEMBL:CHEMBL582180SB 204070CHEMBL:CHEMBL2028050CHEMBL:CHEMBL589723DOMIPHEN BROMIDECHEMBL:CHEMBL525826ANTIANXIETY AGENTESTRADIOL VALERATEDICOFOLGREPAFLOXACIN(-)-U-50488 METHANE SULFONATESPIPERONE HYDROCHLORIDEGUANIDINE HYDROCHLORIDETRAZODONECYCLOBENZAPRINECHEMBL:CHEMBL537087QUINACRINE DIHYDROCHLORIDECHEMBL:CHEMBL541585BENZYL SALICYLATESOTALOL HYDROCHLORIDECHEMBL:CHEMBL598369CHEMBL:CHEMBL2028063CHEMBL:CHEMBL590947N-AMINOHEXYL-5-CHLORO-1-NAPTHALENESULFONAMIDE HYDROCHLORIDECHEMBL:CHEMBL529640SB 216763CHEMBL:CHEMBL585243NISOXETINE HYDROCHLORIDEECONAZOLE NITRATEGR 127935PROBUCOLCHEMBL:CHEMBL1256663FLECAINIDE ACETATECHEMBL:CHEMBL580159CHEMBL:CHEMBL526981AMIFAMPRIDINE5-(N-METHYL-N-ISOBUTYL)AMILORIDECHEMBL:CHEMBL579105BMY-7378CHEMBL:CHEMBL549208SPIROXATRINECHEMBL:CHEMBL1256740BISOPROLOLVERNAKALANT HYDROCHLORIDECHEMBL:CHEMBL600374CHEMBL:CHEMBL577014CHEMBL:CHEMBL525486CALMIDAZOLIUM CHLORIDECHEMBL:CHEMBL581240CHEMBL:CHEMBL549216(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEMETHYLROSANILINEDEXPROPRANOLOL HYDROCHLORIDENALOXONE BENZOYLHYDRAZONECHEMBL:CHEMBL531611MITOTANEMIBEFRADILISOQUINEMOXIFLOXACINCP55940CHEMBL:CHEMBL528245AZD7009ELLIPTECINEDALFAMPRIDINECHEMBL:CHEMBL538542CHEMBL:CHEMBL532525CHEMBL:CHEMBL580353YOHIMBINE HYDROCHLORIDEBRL-54443CHEMBL:CHEMBL1256647PIMOZIDECHEMBL:CHEMBL1079460AG 490SB 224289PNU-37883CHEMBL:CHEMBL2028044DOXAZOSIN MESYLATEPROPAFENONE HYDROCHLORIDEVESNARINONELEVOMETHADYLCHEMBL:CHEMBL606159CHEMBL:CHEMBL588501KETANSERIN TARTRATECALCIMYCINCHEMBL:CHEMBL586962ALPRENOLOL HYDROCHLORIDECHEMBL:CHEMBL589946CHEMBL:CHEMBL585966VITAMIN ACHEMBL:CHEMBL590674LIDOFLAZINEALEMCINALAFIMOXIFENECHEMBL:CHEMBL601528VINPOCETINEDICHLOROPHENPRENYLAMINETHIRAMPHENOXYBENZAMINE HYDROCHLORIDEBENZTROPINE MESYLATECHEMBL:CHEMBL597857CHEMBL:CHEMBL602552BENOXATHIAN HYDROCHLORIDECHEMBL:CHEMBL583555CHEMBL:CHEMBL1256735CHEMBL:CHEMBL546168TERODILINECSCDOBUTAMINE HYDROCHLORIDERISPERIDONEERYTHROMYCINCHEMBL:CHEMBL592123SEMAXANIBCHEMBL:CHEMBL585686LOXAPINE SUCCINATECHEMBL:CHEMBL2028068NITRENDIPINEPYRITHIONE ZINCSKF-38393CHEMBL:CHEMBL1315166CHEMBL:CHEMBL584235CHEMBL:CHEMBL589922JP1302SALMETEROL XINAFOATECHEMBL:CHEMBL609628CHEMBL:CHEMBL548469FLUPIRTINE MALEATEAMPEROZIDE HYDROCHLORIDEBEMESETRONPAROXETINE HYDROCHLORIDE, HEMIHYDRATECHEMBL:CHEMBL590212AMIFAMPRIDINE PHOSPHATEMETERGOLINECHEMBL:CHEMBL2028066CHEMBL:CHEMBL547483OLEIC ACIDCHEMBL:CHEMBL2028045TRIFLUPROMAZINE HYDROCHLORIDENPS 2143CHEMBL:CHEMBL534084CHEMBL:CHEMBL1256660CHEMBL:CHEMBL601534MAPROTILINE HYDROCHLORIDECHEMBL:CHEMBL579315DISOPYRAMIDE PHOSPHATECHEMBL:CHEMBL591887CHEMBL:CHEMBL578294CHEMBL:CHEMBL1740701CHEMBL:CHEMBL533921BENZAMIL HYDROCHLORIDEELIPRODILCHEMBL:CHEMBL548338IDARUBICINRALOXIFENE HYDROCHLORIDECHEMBL:CHEMBL607308IMIPRAMINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDEDOXEPIN HYDROCHLORIDEASTEMIZOLECHEMBL:CHEMBL525106SKF89976ACLARITHROMYCINISOLIQUIRITIGENINSAQUINAVIR MESYLATEWIN55212-2PROMAZINE HYDROCHLORIDEZIMELIDINE DIHYDROCHLORIDEORPHENADRINE HYDROCHLORIDECHEMBL:CHEMBL534319PYRROLIDINE DITHIOCARBAMIC ACID, AMMONIUM SALTCHEMBL:CHEMBL494669PHENOLPHTHALEINCHEMBL:CHEMBL602312HYDROXYZINECHEMBL:CHEMBL580140TRIFLUPERIDOL HYDROCHLORIDEAMSACRINE HYDROCHLORIDECHEMBL:CHEMBL1437888DESIPRAMINE HYDROCHLORIDEOXYBUTYNINCHEMBL:CHEMBL601325FLUPHENAZINE HYDROCHLORIDECISAPRIDECHEMBL:CHEMBL1369632CHEMBL:CHEMBL582486CHEMBL:CHEMBL547488ZIRAMCHEMBL:CHEMBL532510DROPERIDOLDESMETHEYLASTEMIZOLERITANSERINCLORGYLINE HYDROCHLORIDECHEMBL:CHEMBL524930DARUISOLINEL-741,626OMARIGLIPTINCHEMBL:CHEMBL580516DAPHCHEMBL:CHEMBL592786CELIPROLOLFLUOXETINE HYDROCHLORIDECHLORANILCHEMBL:CHEMBL592344L745870CHEMBL:CHEMBL586033PD-169316RPR260243METHADONE HYDROCHLORIDE
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |