Protein detail

ZP4

Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

Protein symbol ZP4	UniProt ID Q12836	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Predicted membrane proteinsPredicted secreted proteins

Basic Information

Protein Names

Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

Protein Class

Predicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Transmembrane

506..526; Helical

Transmembrane Count

Ensembl

ENSG00000116996

Entrez Gene Symbol

ZP4

Gene Synonym

ZP1BZPBZPB2

Gene Description

Zona pellucida glycoprotein 4

Chromosome

Position

237877864-237890922

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificCardiomyocytesSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificnaive B-cell

Function & Pathway

Protein Function

Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	Yes	Yes	No
ecm	ecm	MatrixDB	Yes	No	Yes	Yes	No
ecm	ecm	GO_Intercell	Yes	No	Yes	Yes	No
ecm	ecm	Ramilowski_location	Yes	No	Yes	Yes	No
ecm	ecm	CellCellInteractions	Yes	No	Yes	Yes	No
zona_pellucida_glycoprotein	ecm	HGNC	Yes	No	Yes	Yes	No
ecm	ecm	OmniPath	Yes	No	Yes	Yes	No
extracellular	extracellular	LOCATE	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
TREX transcription-export complexDX39A variant	ALYREF CHTOP DDX39A ERH FYTTD1 LUZP4 NCBP3 POLDIP3 SARNP THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 ZC3H11A	O00148 O75152 P82979 P84090 Q13769 Q53F19 Q6I9Y2 Q86V81 Q86W42 Q8NI27 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9P127 Q9Y3Y2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-28950645	33191911 14755292
TREX transcription-export complexDX39B variant	ALYREF CHTOP DDX39B ERH FYTTD1 LUZP4 NCBP3 POLDIP3 SARNP THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 ZC3H11A	O75152 P82979 P84090 Q13769 Q13838 Q53F19 Q6I9Y2 Q86V81 Q86W42 Q8NI27 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9P127 Q9Y3Y2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:7APKintact:EBI-9017767PDB:7ZNK	37020021 14755292 33191911

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	39247822

Sequence, Structure & Domains

Sequences

Length

540

Mass

59,400

Sequence

MWLLRCVLLCVSLSLAVSGQHKPEAPDYSSVLHCGPWSFQFAVNLNQEATSPPVLIAWDNQGLLHELQNDSDCGTWIRKGPGSSVVLEATYSSCYVTEWDSHYIMPVGVEGAGAAEHKVVTERKLLKCPMDLLARDAPDTDWCDSIPARDRLPCAPSPISRGDCEGLGCCYSSEEVNSCYYGNTVTLHCTREGHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAFVLFQFPFTSCGTTRQITGDRAVYENELVATRDVKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPINVQVFTLPPPFPETQPGPLTLELQIAKDKNYGSYYGVGDYPVVKLLRDPIYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVQKALDLPFPSHHQRFSIFTFSFVNPTVEKQALRGPVHLHCSVSVCQPAETPSCVVTCPDLSRRRNFDNSSQNTTASVSSKGPMILLQATKDPPEKLRVPVDSKVLWVAGLSGTLILGALLVSYLAVKKQKSCPDQMCQ

3D Structural Models

Domain & Motif Annotations

Domain (CC)

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Domain (FT)

141..183; P-type; 188..466; ZP

Protein Families

ZP domain family
ZPB subfamily

Sequence Similarities

Belongs to the ZP domain family. ZPB subfamily.

Clinical Relevance

Antibody

HPA008547