Protein detail
STX4
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
Entry name STX4 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
276..296; Helical; Anchor for type IV membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
p35-2STX4A
Gene Description
Syntaxin 4
Chromosome
16
Position
31032889-31042975
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadrenal glandBrain Regional SpecificponsCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificCGE interneuron
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0000322 storage vacuole
- GO:0005615 extracellular space
- GO:0005768 endosome
- GO:0005773 vacuole
- GO:0005802 trans-Golgi network
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0012505 endomembrane system
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0030027 lamellipodium
- GO:0030670 phagocytic vesicle membrane
- GO:0031201 SNARE complex
- GO:0032420 stereocilium
- GO:0032589 neuron projection membrane
- GO:0035749 myelin sheath adaxonal region
- GO:0036477 somatodendritic compartment
- GO:0042581 specific granule
- GO:0043197 dendritic spine
- GO:0043219 lateral loop
- GO:0045202 synapse
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098794 postsynapse
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-114516 disinhibition of snare formation
- R-hsa-109582 hemostasis
- R-hsa-199991 membrane trafficking
- R-hsa-449836 other interleukin signaling
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76005 response to elevated platelet cytosolic ca2
- R-hsa-449147 signaling by interleukins
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-199992 trans golgi network vesicle budding
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Cellinker | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STXB4 | Q6ZWJ1 | STX4 | Q12846 | Yes | Yes | Yes | HPRDWangSIGNOR | SIGNOR:15753124HPRD:10394363HPRD:12855681 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
297
Mass
34,180
Sequence
MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12846-1; Sequence=Displayed; Name=2; IsoId=Q12846-2; Sequence=VSP_054603
Alternative Sequence
1..44; MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHK -> MGMTARTKRTRSGSRWWCTRARHGWGARTRSSSTSPLGHPPQ (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..12; Basic and acidic residues
Coiled Coil
43..163
Domain (FT)
200..262; t-SNARE coiled-coil homology
Region
1..21; Disordered; 154..297; Interaction with CENPF
Protein Families
Syntaxin family
Sequence Similarities
Belongs to the syntaxin family.
Clinical Relevance
Disease Involvement
DeafnessNon-syndromic deafness
Antibody
Interaction Protein
ENSG00000049245ENSG00000053501ENSG00000063978ENSG00000079950ENSG00000099940ENSG00000102119ENSG00000105281ENSG00000105402ENSG00000117533ENSG00000117758ENSG00000135823ENSG00000139190ENSG00000143740ENSG00000162236ENSG00000166900ENSG00000168899ENSG00000170310ENSG00000220205ENSG00000244045ENSG00000265808
Interaction Count
20
Interaction Dataset
intact_biogrid_opencellintact_biogridbiogrid_bioplexbiogrid_opencellintact_biogrid_opencell_bioplexintact_biogrid_bioplex