Protein detail
STX4
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
Entry name STX4 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
Protein Class (3)
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
276..296; Helical; Anchor for type IV membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
p35-2STX4A
Gene Description
Syntaxin 4
Chromosome
16
Position
31032889-31042975
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificadrenal glandBrain Regional SpecificponsCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificCGE interneuron
Function & Pathway7
Protein Function (3)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (27)
- GO:0000322 storage vacuole
- GO:0005615 extracellular space
- GO:0005768 endosome
- GO:0005773 vacuole
- GO:0005802 trans-Golgi network
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0012505 endomembrane system
- GO:0016020 membrane
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Molecular Function (4)
Biological Process (3)
KEGG (2)
Reactome (14)
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-114516 disinhibition of snare formation
- R-hsa-109582 hemostasis
- R-hsa-199991 membrane trafficking
- R-hsa-449836 other interleukin signaling
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76005 response to elevated platelet cytosolic ca2
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Mediation Categories (5)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence29
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Cellinker | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STXB4 | Q6ZWJ1 | STX4 | Q12846 | Yes | Yes | Yes | HPRDWangSIGNOR | SIGNOR:15753124HPRD:10394363HPRD:12855681 |
Protein Complex Composition (2)
Sequence, Structure & Domains11
Sequences
Length
297
Mass
34,180
Sequence
MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12846-1; Sequence=Displayed; Name=2; IsoId=Q12846-2; Sequence=VSP_054603
Alternative Sequence
1..44; MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHK -> MGMTARTKRTRSGSRWWCTRARHGWGARTRSSSTSPLGHPPQ (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1..12; Basic and acidic residues
Coiled Coil
43..163
Domain (FT)
200..262; t-SNARE coiled-coil homology
Region
1..21; Disordered; 154..297; Interaction with CENPF
Protein Families
Syntaxin family
Sequence Similarities
Belongs to the syntaxin family.
Clinical Relevance6
Disease Involvement (2)
DeafnessNon-syndromic deafness
Drugs (3)
Antibody
Interaction Protein (20)
ENSG00000049245ENSG00000053501ENSG00000063978ENSG00000079950ENSG00000099940ENSG00000102119ENSG00000105281ENSG00000105402ENSG00000117533ENSG00000117758ENSG00000135823ENSG00000139190ENSG00000143740ENSG00000162236ENSG00000166900ENSG00000168899ENSG00000170310ENSG00000220205ENSG00000244045ENSG00000265808
Interaction Count
20
Interaction Dataset (6)
intact_biogrid_opencellintact_biogridbiogrid_bioplexbiogrid_opencellintact_biogrid_opencell_bioplexintact_biogrid_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |