Protein detail
M3K12
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Protein symbol M3K12 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Protein Class
EnzymesPredicted intracellular proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Kinases:STE Ser/Thr protein kinases
- ENZYME proteins:Transferases
- Enzymes
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym
DLKMEKK12MUKZPKZPKP1
Gene Description
Mitogen-activated protein kinase kinase kinase 12
Chromosome
12
Position
53479669-53500063
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEarly spermatids
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Kinases:STE Ser/Thr protein kinases
- ENZYME proteins:Transferases
- Enzymes
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0004706 JUN kinase kinase kinase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0019901 protein kinase binding
- GO:0042803 protein homodimerization activity
- GO:0043539 protein serine/threonine kinase activator activity
- GO:0106310 protein serine kinase activity
Biological Process
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| M3K12 | Q12852 | MP2K4 | P45985 | Yes | Yes | No | Sparser_ProtMapperKEGG-MEDICUSSIGNORProtMapperHPRDCui2007SignaLink3WangREACH_ProtMapper | HPRD:10187804SignaLink3:8637721ProtMapper:25594179SignaLink3:23331499SIGNOR:25594179 |
| JIP1 | Q9UQF2 | M3K12 | Q12852 | Yes | Yes | Yes | HPRDSIGNORSignaLink3 | HPRD:10490659SignaLink3:10490659SignaLink3:23331499SignaLink3:9868371SIGNOR:11432832 |
| MBIP1 | Q9NS73 | M3K12 | Q12852 | Yes | Yes | No | HPRDLit-BM-17SignaLink3 | SignaLink3:10801814SignaLink3:23331499Lit-BM-17:10801814HPRD:10801814 |
| SH3R1 | Q7Z6J0 | M3K12 | Q12852 | Yes | Yes | No | HPRDSIGNORSignaLink3 | HPRD:14504284SIGNOR:12514131SignaLink3:23331499SIGNOR:11416147SignaLink3:12514131 |
| M3K12 | Q12852 | MP2K7 | O14733 | Yes | Yes | No | KEGG-MEDICUSSIGNORHPRDCui2007SignaLink3Wang | HPRD:10187804SignaLink3:23331499SIGNOR:28111074SignaLink3:15749080 |
| M3K12 | Q12852 | ML12B | O14950 | Yes | Yes | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:11781833ProtMapper:11781833 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
859
Mass
93,219
Sequence
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12852-1; Sequence=Displayed; Name=2; IsoId=Q12852-2; Sequence=VSP_044646
Alternative Sequence
46; H -> QCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANS (in isoform 2)
3D Structural Models
Turn
309..312
Helix
122..124; 157..160; 163..165; 198..203; 210..229; 239..241; 264..271; 272..276; 279..282; 290..305; 315..323; 337..346; 351..353; 357..372; 376..396
Beta Strand
126..134; 137..144; 147..153; 176..180; 187..191; 242..244; 250..252
3D Structure
X-ray crystallography (12)
Domain & Motif Annotations
Compositional Bias
539..551; Basic residues; 572..584; Gly residues; 621..631; Gly residues; 671..692; Gly residues; 719..730; Acidic residues; 732..756; Polar residues; 765..779; Polar residues; 780..790; Basic and acidic residues; 800..816; Pro residues
Domain (CC)
Interacts with MBIP through the leucine-zipper motif.
Domain (FT)
125..366; Protein kinase
Region
51..73; Disordered; 390..411; Leucine-zipper 1; 443..464; Leucine-zipper 2; 524..587; Disordered; 613..859; Disordered
Protein Families
- Protein kinase superfamily
- STE Ser/Thr protein kinase family
- MAP kinase kinase kinase subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.