Protein detail

M3K12

Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)

Entry name
M3K12
UniProt ID
Q12852
EVMP confidence score
0.28
Supporting publications (n)
2
Transmembrane count
Protein classification
EnzymesPredicted intracellular proteinsTransporters
Basic Information
Protein Names
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Protein Class (3)
EnzymesPredicted intracellular proteinsTransporters
Protein Function (5)
  • Predicted intracellular proteins
  • Kinases:STE Ser/Thr protein kinases
  • ENZYME proteins:Transferases
  • Enzymes
  • Transporters:Accessory Factors Involved in Transport
Ensembl
ENSG00000139625
Entrez Gene Symbol
MAP3K12
Gene Synonym (5)
DLKMEKK12MUKZPKZPKP1
Gene Description
Mitogen-activated protein kinase kinase kinase 12
Chromosome
12
Position
53479669-53500063
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEarly spermatids
Function & Pathway
Protein Function (5)
  • Predicted intracellular proteins
  • Kinases:STE Ser/Thr protein kinases
  • ENZYME proteins:Transferases
  • Enzymes
  • Transporters:Accessory Factors Involved in Transport
Cellular Component (5)
Molecular Function (9)
Biological Process (3)
KEGG
hsa04010 MAPK signaling pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence15

Ligand-Receptor Signaling (8)

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath
receptorreceptorscConnectYes

Regulatory Interaction Network (6)

6 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
M3K12Q12852MP2K4P45985YesYesSparser_ProtMapperKEGG-MEDICUSSIGNORProtMapperHPRDCui2007SignaLink3WangREACH_ProtMapperHPRD:10187804SignaLink3:8637721ProtMapper:25594179SignaLink3:23331499SIGNOR:25594179
JIP1Q9UQF2M3K12Q12852YesYesYesHPRDSIGNORSignaLink3HPRD:10490659SignaLink3:10490659SignaLink3:23331499SignaLink3:9868371SIGNOR:11432832
MBIP1Q9NS73M3K12Q12852YesYesHPRDLit-BM-17SignaLink3SignaLink3:10801814SignaLink3:23331499Lit-BM-17:10801814HPRD:10801814
SH3R1Q7Z6J0M3K12Q12852YesYesHPRDSIGNORSignaLink3HPRD:14504284SIGNOR:12514131SignaLink3:23331499SIGNOR:11416147SignaLink3:12514131
M3K12Q12852MP2K7O14733YesYesKEGG-MEDICUSSIGNORHPRDCui2007SignaLink3WangHPRD:10187804SignaLink3:23331499SIGNOR:28111074SignaLink3:15749080
M3K12Q12852ML12BO14950YesYesPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapperSIGNOR:11781833ProtMapper:11781833

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
859
Mass
93,219
Sequence
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12852-1; Sequence=Displayed; Name=2; IsoId=Q12852-2; Sequence=VSP_044646
Alternative Sequence
46; H -> QCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANS (in isoform 2)

3D Structural Models

Turn
309..312
Helix
122..124; 157..160; 163..165; 198..203; 210..229; 239..241; 264..271; 272..276; 279..282; 290..305; 315..323; 337..346; 351..353; 357..372; 376..396
Beta Strand
126..134; 137..144; 147..153; 176..180; 187..191; 242..244; 250..252
3D Structure
X-ray crystallography (12)

Domain & Motif Annotations

Compositional Bias
539..551; Basic residues; 572..584; Gly residues; 621..631; Gly residues; 671..692; Gly residues; 719..730; Acidic residues; 732..756; Polar residues; 765..779; Polar residues; 780..790; Basic and acidic residues; 800..816; Pro residues
Domain (CC)
Interacts with MBIP through the leucine-zipper motif.
Domain (FT)
125..366; Protein kinase
Region
51..73; Disordered; 390..411; Leucine-zipper 1; 443..464; Leucine-zipper 2; 524..587; Disordered; 613..859; Disordered
Protein Families (3)
  • Protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase kinase subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Clinical Relevance
Drugs
CEP-1347
Antibody (2)
HPA039936HPA071996
Interaction Protein
ENSG00000146648
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
PMIDTitleRelated sentences
38490958Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available